Gated stress-only 99mTc myocardial perfusion SPECT imaging accurately assesses coronary artery disease.

In today's cost containment environment it is important to consider changes to standard protocols which would reduce cost, particularly if there is no significant loss of diagnostic accuracy. The aim of the present study was to assess the usefulness of a gated stress-only Tc sestamibi protocol in comparison to conventional gated dual isotope rest-stress myocardial perfusion single photon emission computed tomography (SPECT) in the detection and localization of coronary artery disease (CAD). Sixty-five consecutive patients (65+/-10 years, 22 women) who had undergone conventional gated perfusion SPECT were chosen retrospectively. Fifty-three of these 65 patients had previous coronary arteriography, 45 with at least one stenosis, eight without stenosis, and 12 of these 65 patients had <5% likelihood of CAD. Three readers interpreted the gated stress-only and dual isotope studies in separate sessions blinded to (1). their previous readings, (2). the interpretation by others, and (3). the angiographic results. Readers used a five-point scale to score their visual and quantitative assessment of perfusion, function and compromised vascular territory. Their average score was used for determination of the accuracy by using receiver operating characteristic (ROC) analysis of the techniques. The areas under ROC curves were determined for the detection of CAD and localization of vascular territories. Fifty-four of these patients had 97 significant stress induced perfusion defects as determined by the CEqual quantitative program. The agreement between protocols for the assessment of reversibility in these 97 defects was analysed. There were no statistically significant differences between dual isotope rest/stress and gated stress-only studies for the detection and localization of CAD. The area under the dual isotope rest/stress ROC curve was 0.78+/-0.07 compared to the area under the gated stress-only ROC curve of 0.80+/-0.06, resulting in P=0.30. For the combined vessels comparison of the area under the dual isotope rest/stress ROC curve was 0.73+/-0.04 versus the area under the gated stress-only ROC curve of 0.74+/-0.04, resulting in P=0.27. Similar non-significant differences were obtained when comparing the area under the dual isotope versus gated stress-only ROC curves for the left anterior descending vascular territory (LAD, 0.61+/-0.08 vs 0.660.08, P=0.14), the left circumflex vascular territory (LCX, 0.82+/-0.07 vs 0.81+/-0.06, P =0.47) or the right coronary vascular territory (RCA, 0.80+/-0.06 vs 0.78+/-0.06, P=0.28). The analysis of the reversibility of stress induced perfusion defects yielded a global agreement between protocols of 93% (kappa=0.42). The differences were due to the expert readers, using the gated stress-only protocol, misinterpreting some patients with attenuation artefacts, subendocardial infarction and functional stunning. These results show that the lower cost gated stress-only myocardial Tc myocardial perfusion SPECT studies are comparable to the conventional dual isotope studies when the clinical question is the detection and localization of coronary artery disease. Nevertheless, we also showed that this approach is limited when attempting to interpret the reversibility of stress induced perfusion defects in patients who exhibit attenuation artefacts, subendocardial infarction and functional stunning.

Evaluation of left ventricular endocardial volumes and ejection fractions computed from gated perfusion SPECT with magnetic resonance imaging: comparison of two methods.

BACKGROUND: Two methods of computing left ventricular volumes and ejection fraction (EF) from 8-frame gated perfusion single photon emission computed tomography (SPECT) were compared with each other and with magnetic resonance (MR) imaging. METHODS AND RESULTS: Thirty-five subjects underwent 8-frame gated dual-isotope SPECT imaging and 12- to 16-frame gated MR imaging. Endocardial boundaries on short-axis MR images were hand traced by experts blinded to any SPECT results. Volumes and EF were computed with the use of Simpson's rule. SPECT images were analyzed for the same functional variables with the use of 2 automatic programs, Quantitative Gated SPECT (QGS) and the Emory Cardiac Toolbox (ECTb). The mean difference between MR and SPECT EF was 0.008 for ECTb and 0.08 for QGS. QGS showed a slight trend toward higher correlation for EF (r = 0.72, SE of the estimate = 0.08) than ECTb (r = 0.70, SE of the estimate = 0.09). For both SPECT methods, left ventricular volumes were similarly correlated with MR, although SPECT volumes were higher than MR values by approximately 30%. CONCLUSIONS: QGS and ECTb values of cardiac function computed from 8-frame gated perfusion SPECT correlate very well with each other and correlate well with MR. Averaged over all subjects, ECTb measurements of EF are not significantly different from MR values but QGS significantly underestimates the MR values.

Diagnostic performance of an expert system for the interpretation of myocardial perfusion SPECT studies.

UNLABELLED: An expert system (PERFEX) developed for the computer-assisted interpretation of myocardial perfusion SPECT studies is now becoming widely available. To date, a systematic validation of the diagnostic performance of this expert system for the interpretation of myocardial perfusion SPECT studies has not been reported. METHODS: To validate PERFEX's ability to detect and locate coronary artery disease (CAD), we analyzed 655 stress/rest myocardial perfusion prospective SPECT studies in patients who also underwent coronary angiography. The patient population comprised CAD patients (n = 480) and healthy volunteers (n = 175) (449 men, 206 women). Data from 461 other patient studies were used to implement and refine 253 heuristic rules that best correlated the presence and location of left ventricular myocardial perfusion defects on SPECT studies with angiographically detected CAD and with human expert visual interpretations. Myocardial perfusion defects were automatically identified as segments with counts below sex-matched normal limits. PERFEX uses the certainty of the location, size, shape, and reversibility of the perfusion defects to infer the certainty of the presence and location of CAD. The visual interpretations of tomograms and polar maps, vessel stenosis from coronary angiography, and PERFEX interpretations were all accessed automatically from databases and were used to automatically generate comparisons between diagnostic approaches. RESULTS: Using the physician's reading as a gold standard, PERFEX's sensitivity and specificity levels for detection and localization of disease were, respectively, 83% and 73% for CAD, 76% and 66% for the left anterior descending artery, 90% and 70% for the left circumflex artery, and 74% and 79% for the right coronary artery. These results were extracted from a receiver operating characteristic curve using the average optimal input certainty factor. CONCLUSION: This study shows that the diagnostic performance of PERFEX for interpreting myocardial perfusion SPECT studies is comparable with that of nuclear medicine experts in detecting and locating CAD.

Three-dimensional color-modulated display of myocardial SPECT perfusion distributions accurately assesses coronary artery disease.

UNLABELLED: The objective of this study was to compare visual assessment of 3-dimensional color-modulated (to counts) surface displays with visual assessment of oblique tomographic slices of myocardial SPECT perfusion distributions in the detection and localization of coronary artery disease (CAD). METHODS: Sixty-two consecutive patients (41 men, 21 women; mean age, 61 +/- 11 y) who had undergone conventional dual-isotope perfusion SPECT were retrospectively chosen; 50 had undergone coronary arteriography previously, and 12 had less than a 5% likelihood of CAD. Four readers interpreted the 3-dimensional displays and slices in separate sessions while unaware of the findings of previous readings, the interpretations of others, and the angiographic results. The readers used a 5-point scoring system. Their average score was used for receiver operating characteristic (ROC) analysis. The area under the ROC curves was determined so that the ability of the 2 methods to detect and localize CAD could be compared. RESULTS: No significant differences were found between visual interpretation of 3-dimensional displays and visual interpretation of slices. CONCLUSION: These preliminary results indicate that visual interpretation of 3-dimensional displays of myocardial perfusion SPECT distributions may someday replace visual assessment of conventional slices without loss of diagnostic accuracy.

Left ventricular function and perfusion from gated SPECT perfusion images: an integrated method.

UNLABELLED: A new technique for computing left ventricular function, including left ventricular volumes, mass and ejection fraction, has been developed. This method is a logical extension of the results of a standard perfusion quantification technique; thus, it allows integration of perfusion and functional information. METHODS: Anatomically based models of the endocardial and epicardial surfaces are generated using the myocardial samples for which perfusion values are quantified, for all frames in the cardiac cycle. With these surface points, left ventricular chamber volume and myocardial volume can be computed. A computer simulation was used to determine the sensitivity of the approach to the assumptions of the model. Validation of volume, mass and ejection fraction was performed with correlative MR studies, and ejection fraction and left ventricular volumes were further investigated using correlative first-pass studies. RESULTS: Automated processing was successful in 96% of the cases analyzed. End diastolic volume, end systolic volume, left ventricular mass and left ventricular ejection fraction correlated with MRI with r = 0.97, 0.99, 0.87, and 0.85, respectively. Ejection fraction from tomography correlated with first-pass values with r = 0.82, and end diastolic and end systolic volumes from tomography correlated with first-pass values with r = 0.85 and r = 0.91, respectively. CONCLUSION: The new integrated approach is accurate and robust for computing both perfusion and function from perfusion tomograms.

Left ventricular dilatation and multivessel coronary artery disease on thallium-201 SPECT are important prognostic indicators in patients with large defects in the left anterior descending distribution.

This study examines the importance of left ventricular (LV) dilatation, and evidence of multivessel coronary artery disease identified on thallium-201 (TI-201) single-photon emission computed tomographic (SPECT) scintigrams, for predicting long-term outcome in patients with an extensive left anterior descending (LAD) perfusion deficit. Impaired contractility of the left ventricle determined by low ejection fraction, elevated LV end-systolic volume, and dilatation of the left ventricle are known as major predictors of mortality after myocardial infarction. TI-201 single-photon emission computed tomography primarily reveals status of perfusion/redistribution, but also contains indirect information on LV function. To date, there are no TI-201 SPECT data on impaired function of the left ventricle (LV dilatation) and extent of perfusion deficits, discussed together as correlates of survival. Patient data were prospectively collected in the computer data base at Emory University. A large perfusion defect involving more than one third of the LAD territory was identified in 291 of 2,652 consecutive patients examined with TI-201 SPECT initial and 3-hour redistribution studies. Follow-up data were obtained for 284 patients (98%) at 38 +/- 14 months. Of the 291 patients, 58 died. The most powerful multivariate correlates of death were LV dilatation, multivessel disease, and the ratio of the LAD severity stress score to total severity of SDs stress score. Cox model analysis was used to determine correlates of survival. Three-year survival for patients with LV dilatation was 73% versus 89% without LV dilatation (p < 0.001). Three-year survival in patients with 1-vessel disease ("LAD only") was 94% versus 78% for multivessel disease (p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)