[The cardioprotective action of the anticonvulsant preparation sodium valproate in disorders of cardiac contractile function caused by acute myocardial infarct in rats]. / Kardioprotektivnoe deistvie protivososudorozhnogo preparata val'proata natriia pri narusheniiakh sokratitel'noi funktsii serdtsa, vyzvannye ostrym infarktom miokarda u krys.

The preventive and therapeutical effects of sodium valproate (SV), 200 mg/kg, on cardiac contractile disorders (developed pressure, rate-pressure products, dp/dt) were studied in rats having 2-day myocardial infarction (MI). The postinfarction rather than preinfarction use of SV substantially restricted the depressed resting left ventricular function. Given by two regimens, SV increased cardiac resistance to the maximum isometric load induced by 60-sec ligation of the ascending aorta. The cardioprotective effect of the drug was shown due to its positive chronotropic action rather than its inotropic one. Thus, SV may be used as an effective drug for the prevention and treatment of postinfarct cardiac dysfunctions.

[Nucleic acid content of skeletal muscles during hypokinesia and the recovery period]. / Soderzhanie nukleinovykh kislot v skeletnykh myshtsakh pri gipokineziii v vosstanovitel'nom periode.

The concentration of nucleic acids in the gastrocnemius muscle of Wistar rats was measured during 60-day hypokinesia and 30-day recovery periods. The data obtained indicate that this hypokinetic model leads to an arrest of muscle growth and inhibition of the age-related accumulation of nucleic acids in the gastrocnemius muscle. The content of DNA and RNA genetic matrixes largely depends on the muscle activity. Normalization of the motor function results in an activation of genetic mechanisms of biosynthesis regulation, acceleration of reparative processes and recovery of muscular activity.