Effect of 2-aminoadamantane derivatives on behavior of mice in a modified light/dark test.

The effects of two derivatives of 2-aminoadamantane, enantiomers J447H and J579, on the behavior of male and female C57Bl/6J mice were studied using a modified light/dark test. The substances differed by their effects on the behavior of male mice. J579 reduced the number of rearings. J447H in a dose of 1 mg/kg affected more parameters: it reduced exploratory activity 1 h after administration and stimulated exploratory and motor activity in 2 h. In female mice, J447H significantly reduced the number of peepings into holes in 2 h after administration. The results indicate that further analysis of the effects of J579 and especially J447H is required.

Complex investigation of the effects of lambertianic acid amide in female mice under conditions of social discomfort.

The effects of chronic administration of a new substance lambertianic acid amide and previously synthesized methyl ester of this acid were compared in female mice living under conditions of social discomfort. For modeling social discomfort, female mouse was housed for 30 days in a cage with aggressive male mouse kept behind a transparent perforated partition and observed its confrontations with another male mouse daily placed to the cage. The new agent more effectively than lambertianic acid methyl ester improved communicativeness and motor activity of animals, reduced hypertrophy of the adrenal glands, and enhanced catalase activity in the blood. These changes suggest that lambertianic acid amide produces a pronounced stress-protective effect under conditions of social discomfort.

[Effects of buspirone complex with glycyrrhizic acid on behavior of mice with anxious-depressive state].

We report here studies of the effects of subchronic administration of 5-HT1A receptor agonist buspirone and its novel complex with glycyrrhizic acid (GA) to C57BL/6J mice at the different stages of the anxious-depressive state formation, induced by conditions of social stress. The experiment of agents' administration during the conditions of stress (beginning with initial stage) showed that only complex had a protective effect revealed in prevention of the anxiety with the high level of mice communicativeness maintenance. At the stage when the anxious-depressive state is completely formed, buspirone and its complex with GA decreased mice motor activity however complex--less significantly. Here we discuss a possible mechanism of action of investigated agents on the background of changes in the sensitivity of 5-HT1A receptors, induced by the formation of the anxious-depressive state of mice with experience of social stress. Despite of different effects of agents depending on the stage of the anxious-depressive state development, novel buspirone complex with GA has some advantage over buspirone.

[Effects of buspirone on the behavior of female mice in a model of social discomfort].

The influence of acute and chronic (14 days) buspirone administration (1 mg/kg, intraperitoneally) on the behavior of C57BL/6J female mice, being in social discomfort, were studied. The conditions of social discomfort include the permanent habitation of females in the cage with aggressive males through a perforated partition and daily presence during intermale confrontations. The dynamic changes of 5-HT1A-receptor sensitivity in the brain of female mice, estimated by the female behavior after 30 min ofbuspirone administration, were discovered. The sensitivity increased at the early stages of pathological behavior development (10 days) and decreased after 20-30 days. Females who had reduced of 5-HT1A receptor sensitivity after 30 day of maintenance in social discomfort conditions also showed a decreased sensitivity on chronic buspirone administration.