Growth trend during the first six months of life in male infants with different type of feeding.

AIM: The aim of the study was to assess the differences in the growth trend of male infants fed with human milk (HM), formula feeding (FF) and both (HM+FF), focusing the attention on weight increase in the first six months of life. METHODS: We enrolled 146 healthy male infants born from a spontaneous delivery; exclusion criteria were all conditions that required parenteral nutrition; the follow-up visits were at 1, 2, 3, 4, 5, 6 months of life. All infants were subsequently divided into three groups depending on the three feeding type (HM, FF, HM+FF) and then in other three subgroups depending on birth weight and gestational age (A, B, C). RESULTS: The three feeding type groups appeared homogeneous for gestational age and birth weight at every time of follow-up. The weight differences between subgroup A, B, C were not statistically significant, showing a regular growth trends. CONCLUSION: It is possible to assess the nutritional balance and the adequacy in composition of formula. This suggests that, in our population, the possible factors that could influence the rapid weight gain, characterized by a peak in the growth trend profile, do not concern the nutrition during the first six months of life but at most the weaning.

ACTH and cortisol cord plasma concentrations in preterm and term infants.

OBJECTIVE: To measure the adrenocorticotropic hormone (ACTH) and cortisol (F) cord plasma levels in preterm and term infants in relation to their mode of delivery. STUDY DESIGN: We studied 180 newborns appropriate for gestational age (GA) with birth weights between 365 and 4380 g and GAs between 21 and 41 weeks divided into three groups: born by vaginal delivery (VD), elective cesarean section (ECS) and emergency cesarean section (EMCS). ACTH and F levels were valued with enzyme-linked immunosorbent assay testing. Median concentrations were compared between groups by Student's T-test for independent and paired data. Multiple regression analysis was used to investigate the effect of GA on F and ACTH concentrations. RESULT: A significant positive correlation between GA and plasma concentrations of ACTH (P<0.05) was found in the whole population, but not between GA and F (P=NS). A significant positive correlation was found between GA and plasma concentrations of both ACTH (P=0.01) and F (P=0.03) in VD. In those born by ECS, we demonstrated a positive correlation not only between plasma concentrations of ACTH (P=0.0000) and F (P=0.00002), respectively, with GA, but also a correlation between ACTH and F (P=0.0004). No significant correlations were found in the EMCS group (P=NS). CONCLUSION: Our results suggest simultaneous pituitary-adrenal maturation, which is complete only at term. The responsiveness of preterm babies to different stressful stimulations is similar to the terms' but quantitatively lower, and the secretion of ACTH and F may not suffice in severe pathological circumstances.