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1.
J Reprod Infant Psychol ; : 1-19, 2024 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-38895982

RESUMO

BACKGROUND: There is growing evidence that antenatal education incorporating relaxation practices can positively influence perinatal psychological wellbeing. However, a paucity of qualitative research is evident. Gaining insight into how and why such education may influence childbearing women, can inform the design of effective educational interventions. This study aimed to explore the perspectives of women and their partners on how and why a single Antenatal Relaxation Class (ARC) might influence perinatal psychological wellbeing and childbirth experiences. METHOD: In this descriptive qualitative study, 17 women and 9 partners participated in semi-structured in-depth interviews and the data were analysed using thematic analysis. The study was carried out in a Scottish NHS Health Board where ARC was provided to expectant parents. FINDINGS: Two themes were generated, namely: 'the turning point', and 'recognition of an inner resource'. Participants perceived ARC as 'the turning point' when they became more confident, equipped, and less fearful and anxious towards childbirth. 'Understanding of the psychophysiological processes of childbirth', 'positive stories', and 'practice of relaxation techniques' were reported as the main reasons for these positive changes. Participants explained ARC had enabled them to access a deep sense of calmness as 'an inner resource' and motivated the use of relaxation techniques as a self-care behaviour throughout pregnancy and childbirth. CONCLUSION: A single antenatal relaxation class has the potential to enhance perinatal psychological wellbeing and childbirth experiences. This study provides valuable insights for maternity services seeking to develop effective health-promoting antenatal education.

2.
Women Birth ; 37(3): 101587, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38508067

RESUMO

BACKGROUND: The role of the midwife is emotionally demanding with many midwives experiencing high levels of stress and burnout, and a great number considering leaving the profession. This has serious implications for the delivery of high-quality, safe maternity care. One of the major factors leading to job dissatisfaction is the conflict between midwives' aspiration of truly 'being' with the woman and the institutional expectations of the role which focuses on the 'doing' aspects of the job. 'Being' present to a woman's psychological needs, whilst meeting the institutional demands, requires high levels of emotional intelligence (EI) in the midwife. Therefore, enhancing midwives' EI could be beneficial. EI EDUCATION PROGRAMME: An EI programme was made available to midwives with the intention to promote their emotional intelligence and enable them to utilise relaxation techniques for those in their care. AIM: To explore midwives' perspectives on the influence of the EI education programme on their emotional wellbeing and experiences of practice. METHOD: The study took a descriptive qualitative approach. Thirteen midwives participated in focus group interviews. The data were analysed using thematic analysis. FINDINGS: The overarching theme of 'The Ripple Effect' included three themes of 'Me and my relationships', 'A different approach to practice' and 'Confidence and empowerment'. The programme was seen to create a positive ripple effect, influencing midwives personally, their approach to practice, and feelings of confidence in their role. CONCLUSION: EI education can reduce emotional stress in midwives, enhance their empathy and feelings of confidence, thus, improving the quality of care they provide.


Assuntos
Serviços de Saúde Materna , Tocologia , Enfermeiros Obstétricos , Obstetrícia , Gravidez , Feminino , Humanos , Tocologia/educação , Pesquisa Qualitativa , Inteligência Emocional , Enfermeiros Obstétricos/psicologia
3.
Complement Ther Clin Pract ; 43: 101341, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33662893

RESUMO

AIM: This study explores the perspectives of expectant parents on the influence of a single antenatal class incorporating education on childbirth physiology and relaxation techniques. METHOD: The data for this qualitative descriptive study were collected via in-depth interviews with six women and three birth partners. FINDINGS: An enhanced understanding of childbirth physiology formed a 'different way of thinking' about childbirth, 'inspired and motivated' the exertion of the learnt relaxation techniques which led to a 'deepsense of calmness' associated with increased confidence and reduced fear. However, reaching such sense of calmness during childbirth required a 'space for relaxation' which was influenced by birth attendants. An overarching theme of 'a positive outlook' towards childbirth was identified. CONCLUSION: Including education on childbirth physiology and a range of relaxation techniques may reduce fear, empower prospective parents and positively influence their experiences of pregnancy and childbirth.


Assuntos
Educação Pré-Natal , Terapia de Relaxamento , Feminino , Humanos , Pais , Parto , Gravidez , Estudos Prospectivos
4.
Health Soc Care Community ; 28(1): 160-172, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31490598

RESUMO

Self-care, which refers to what people do to prevent disease and maintain good health, can alleviate negative health consequences of people experiencing homelessness. The aim of the study was to apply a theoretically informed approach in exploring engagement of people experiencing homelessness in self-care and to identify factors that can be targeted in future health and social care interventions. Qualitative semi-structured interviews were conducted with 28 participants opportunistically recruited from a specialist homelessness healthcare centre of North East Scotland, the United Kingdom (UK). An interview schedule was developed based on the theoretical domains framework (TDF). Interviews were audio-recorded and transcribed verbatim. Six aspects of self-care were explored, including (a) self-awareness of physical and mental health, (b) health literacy, including health seeking behaviour, (c) healthy eating, (d) risk avoidance or mitigation, (v) physical activity and sleep and (e) maintaining personal hygiene. Thematic analysis was conducted by two independent researchers following the Framework Approach. Participants described low engagement in self-care. Most of the barriers to engagement in self-care by participants were related to 'environmental context and resources' domain of TDF. Participants often resorted to stealing or begging for food. Many perceived having low health literacy to interpret health-related information. Visits to churches and charities to get a shower or to obtain free meals were commonplace. Participants expressed pessimism that there was 'nothing' they could do to improve their health and described perceived barriers often too big for them to overcome. Alienation, lack of social support and the perception that they had done irreversible damage to their health prevented their involvement in self-care. The theme of 'social circle' held examples of both enabler and barriers in participants' uptake of risky behaviours. Health and social services should work with persons experiencing homelessness in designing and delivering targeted interventions that address contextual barriers, multi-morbidity, health literacy and self-efficacy.


Assuntos
Comportamentos Relacionados com a Saúde , Nível de Saúde , Pessoas Mal Alojadas/psicologia , Autocuidado/psicologia , Adulto , Idoso , Dieta Saudável , Exercício Físico , Feminino , Letramento em Saúde , Humanos , Higiene , Entrevistas como Assunto , Masculino , Saúde Mental , Pessoa de Meia-Idade , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Pesquisa Qualitativa , Medição de Risco , Escócia , Autoeficácia
5.
BMJ Open ; 9(1): e027475, 2019 01 25.
Artigo em Inglês | MEDLINE | ID: mdl-30782762

RESUMO

OBJECTIVES: This study aimed to use a theoretical approach to understand the determinants of behaviour in patients not home self-administering intravenous antibiotics. SETTING: Outpatient care: included patients were attending an outpatient clinic for intravenous antibiotic administration in the northeast of Scotland. PARTICIPANTS: Patients were included if they had received more than 7 days of intravenous antibiotics and were aged 16 years and over. Twenty potential participants were approached, and all agreed to be interviewed. 13 were male with a mean age of 54 years (SD +17.6). OUTCOMES: Key behavioural determinants that influenced patients' behaviours relating to self-administration of intravenous antibiotics. DESIGN: Qualitative, semistructured in-depth interviews were undertaken with a purposive sample of patients. An interview schedule, underpinned by the Theoretical Domains Framework (TDF), was developed, reviewed for credibility and piloted. Interviews were audio-recorded and transcribed verbatim. Data were analysed thematically using the TDF as the coding framework. RESULTS: The key behavioural determinants emerging as encouraging patients to self-administer intravenous antibiotics were the perceptions of being sufficiently knowledgeable, skilful and competent and that self-administration afforded the potential to work while administering treatment. The key determinants that impacted their decision not to self-administer were lack of knowledge of available options, a perception that hospital staff are better trained and anxieties of potential complications. CONCLUSION: Though patients are appreciative of the skills and knowledge of hospital staff, there is also a willingness among patients to home self-administer antibiotics. However, the main barrier emerges to be a perceived lack of knowledge of ways of doing this at home. To overcome this, a number of interventions are suggested based on evidence-based behavioural change techniques.


Assuntos
Antibacterianos/administração & dosagem , Pacientes Ambulatoriais , Autoadministração , Administração Intravenosa , Adulto , Idoso , Assistência Ambulatorial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recursos Humanos em Hospital/educação , Pesquisa Qualitativa , Escócia
6.
Int J Clin Pharm ; 41(1): 215-227, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30659491

RESUMO

Background Community pharmacists can be an accessible source for advice and support for the people who are homeless, given their utilisation of a variety of currently available services such as dispensing of medicines, drugs and alcohol services. Objective To determine community pharmacists' training, experiences and behavioural determinants in counselling and management of homeless population. Setting UK community pharmacies. Method A questionnaire based on literature and theoretical domains framework was mailed to randomly sampled community pharmacies in England and Scotland (n = 2000). Data were analysed using descriptive and inferential statistics. Main outcome measures Pharmacists' perspectives, pharmacists' training, pharmacists' experiences and behavioural determinants. Results A total of 321 responses (RR 16.1%) were received. Respondents indicated lack of knowledge, skills, intentions as well as contextual factors such as lack of guidelines impacted on their counselling and management of homeless patients. Less than a third (n = 101, 32.2%) indicated that they knew where to refer a homeless patient for social support. Broaching the subject of homelessness was outside their comfort zone (n = 139, 44.3%). Only four (1.2%) respondents could correctly answer all knowledge assessment questions. Conclusions Community pharmacist identified lack of education, training opportunities and guidelines in counselling and management of homeless patients. Targeting community pharmacists' knowledge, skills and intention to provide care to the homeless patients may enable addressing health inequality through community pharmacy.


Assuntos
Atitude do Pessoal de Saúde , Pessoas Mal Alojadas/psicologia , Percepção , Farmacêuticos/psicologia , Papel Profissional/psicologia , Inquéritos e Questionários , Adulto , Idoso , Serviços Comunitários de Farmácia/normas , Aconselhamento/métodos , Aconselhamento/normas , Estudos Transversais , Feminino , Disparidades nos Níveis de Saúde , Pessoas Mal Alojadas/educação , Humanos , Masculino , Pessoa de Meia-Idade , Farmacêuticos/normas , Reino Unido/epidemiologia
7.
Birth ; 45(4): 450-458, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-29411890

RESUMO

BACKGROUND: Breastfeeding rates are typically low for women with a substance-use disorder. This is despite the specific benefits of breastfeeding to alleviate the severity of neonatal abstinence syndrome and the well-documented generic advantages. This study explored the feasibility of in-hospital, tailored breastfeeding support for the substance-exposed mother and baby. METHODS: This was a mixed-methods feasibility study undertaken in Scotland from April 2014 to May 2015. Women with a substance-use disorder either received standard Baby-Friendly Initiative care only or were given additional support which included a dedicated breastfeeding support worker, personalized capacity-building approach, and a low-stimuli environment for 5 days. Feasibility outcome measures were maternal recruitment, satisfaction and acceptability of support, breastfeeding on fifth postnatal day, and severity of neonatal abstinence syndrome. RESULTS: Fourteen mother-infant dyads participated. Intervention participants demonstrated higher rates of continued breastfeeding and reported a greater degree of satisfaction with support and confidence in their breastfeeding ability. Maternal experience of health care practices, attitudes, and postnatal environment influenced their perceptions of breastfeeding support. Breastfed infants were less likely to require pharmacotherapy for neonatal withdrawal and had a shorter hospital stay. CONCLUSIONS: The findings highlight the feasibility of tailored breastfeeding support for the substance-exposed mother and baby and endorse the promotion and support of breastfeeding for this group. Future research should include a statistically powered randomized controlled trial to evaluate clinical efficacy.


Assuntos
Analgésicos Opioides/efeitos adversos , Aleitamento Materno , Tratamento Conservador , Promoção da Saúde/métodos , Serviços de Saúde Materna/organização & administração , Síndrome de Abstinência Neonatal/terapia , Adulto , Estudos de Viabilidade , Feminino , Hospitais , Humanos , Recém-Nascido , Transtornos Relacionados ao Uso de Opioides/complicações , Projetos Piloto , Gravidez , Escócia , Inquéritos e Questionários , Adulto Jovem
8.
Int J Clin Pharm ; 40(2): 394-402, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29332145

RESUMO

Background Multi-compartment compliance aids (MCAs) are promoted as a potential solution to medicines non-adherence despite the absence of high quality evidence of effectiveness of MCA use impacting medicines adherence or any clinical outcomes. Furthermore, there is a lack of qualitative research which focuses on the perspectives of older people receiving MCAs. Objectives To describe experiences and beliefs surrounding very sheltered housing (VSH) residents' use of MCAs with emphasis on issues of personalisation, reablement, shared decision-making, independence and support. Setting VSH in north east Scotland. Methods Qualitative, face-to-face interviews with 20 residents (≥ 65 years, using MCA > 6 months) in three VSH complexes. Interviews focused on: when and why the MCA was first introduced; who was involved in making that decision; how the MCA was used; perceptions of benefit; and any difficulties encountered. Interviews were audiorecorded, transcribed and analysed using a framework approach. Main outcome measure Experiences and beliefs surrounding use of MCAs. Results Nine themes were identified: shared decision-making; independence; knowledge and awareness of why MCA had been commenced; support in medicines taking; knowledge and awareness of medicines; competent and capable to manage medicines; social aspects of carers supporting MCA use; benefits of MCAs; and drawbacks. Conclusion Experiences and beliefs are diverse and highly individual, with themes identified aligning to key strategies and policies of the Scottish Government, and other developed countries around the world, specifically personalisation shared decision making, independence, reablement and support.


Assuntos
Cultura , Tomada de Decisões , Conhecimentos, Atitudes e Prática em Saúde , Habitação para Idosos/estatística & dados numéricos , Adesão à Medicação , Farmacêuticos/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Escócia/epidemiologia , Inquéritos e Questionários
9.
Br J Gen Pract ; 68(667): e105-e113, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29335329

RESUMO

BACKGROUND: The relocation of formerly homeless patients eligible to transfer from a specialist homeless healthcare centre (SHHC) to mainstream general practices is key to patient integration in the local community. Failure to transition patients conferring eligibility for relocation may also negatively impact on SHHC service delivery. AIM: To explore barriers and facilitators of relocation from the perspectives of formerly homeless patients and healthcare staff involved in their care. DESIGN AND SETTING: Qualitative semi-structured face-to-face and telephone interviews conducted in the north east of Scotland. METHOD: Participants were patients and healthcare staff including GPs, nurses, substance misuse workers, administrative, and local community pharmacy staff recruited from one SHHC, two mainstream general practices, and four community pharmacies. Interview schedules based on the 14 domains of the Theoretical Domains Framework (TDF) were drafted. Transcripts of the interviews were analysed by two independent researchers using a framework approach. RESULTS: Seventeen patients and 19 staff participated. Key barriers and facilitators aligned to TDF domains included: beliefs about consequences regarding relocation; patient intention to relocate; environmental context and resources in relation to the care of the patients and assessing patient eligibility; patient skills in relation to integration; social and professional role and identity of staff and patients; and emotional attachment to the SHHC. CONCLUSION: Implementation of services, which promote relocation and integration, may optimise patient relocation from SHHCs to mainstream general practices. These include peer support networks for patients, better information provision on the relocation process, and supporting patients in the journey of identifying and adjusting to mainstream practices.


Assuntos
Medicina Geral/organização & administração , Acessibilidade aos Serviços de Saúde/organização & administração , Pessoas Mal Alojadas , Transferência de Pacientes/organização & administração , Adulto , Atitude do Pessoal de Saúde , Tomada de Decisões Gerenciais , Feminino , Necessidades e Demandas de Serviços de Saúde , Humanos , Entrevistas como Assunto , Masculino , Pessoa de Meia-Idade , Farmácias , Pesquisa Qualitativa , Escócia , Especialização
10.
Midwifery ; 50: 239-245, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28494389

RESUMO

OBJECTIVE: international guidelines recommend the promotion and protection of breastfeeding for the substance exposed mother and baby. Yet few studies have explored the facilitators, moderators and barriers to successful breastfeeding for women enrolled on opiate maintenance treatment, or suggested targeted support strategies. The aim of this study was to explore the views of women with opiate dependence on proposed elements for inclusion in a breastfeeding support intervention. DESIGN: a qualitative study using think aloud technique. SETTING: tertiary maternity hospital in the North-East of Scotland. Interviews conducted between November 2013 and March 2014. PARTICIPANTS: 6 opiate dependent women within 6 months of giving birth. Participants were enrolled on opiate medication treatment during their pregnancy, had initiated breastfeeding and accessed in-hospital breastfeeding support. FINDINGS: an intervention founded on practical, informational and environmental elements was endorsed as supportive of continued breastfeeding of an infant at risk of Neonatal Abstinence Syndrome. Opiate dependent women were more receptive to strategies promoting a person-centered approach that were specific to their individualized infant feeding needs and delivered within an emotionally supportive environment. Barriers to the acceptability of breastfeeding advice included discouraging, prescriptive and judgemental healthcare actions and attitudes. KEY CONCLUSIONS: there are distinct facilitators, modifiers and barriers to breastfeeding within the context of opiate exposure. Using this awareness to underpin the key features of the design should enhance maternal receptiveness, acceptability and usability of the support intervention. IMPLICATIONS FOR PRACTICE: additional and tailored support interventions are required to meet the specific needs of breastfeeding an infant experiencing opiate withdrawal. The elimination of disempowering institutional actions and attitudes is imperative if a conducive environment in which opiate dependent women feel supported is to be achieved.


Assuntos
Aleitamento Materno/psicologia , Mães/psicologia , Transtornos Relacionados ao Uso de Opioides/psicologia , Apoio Social , Adulto , Feminino , Humanos , Transtornos Relacionados ao Uso de Opioides/complicações , Gravidez , Pesquisa Qualitativa , Escócia
11.
Fam Pract ; 33(6): 572-579, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27543795

RESUMO

BACKGROUND: Suitably qualified non-medical healthcare professionals may now prescribe medicines. Prescribing decision-making can be complex and challenging; a number of influences have been identified among medical prescribers but little appears to be known about influences among non-medical prescribers (NMPs). OBJECTIVE: To critically appraise, synthesize and present evidence on the influences on prescribing decision-making among supplementary and independent NMPs in the UK. METHODS: The systematic review included all studies between 2003 and June 2013. Included studies researched the prescribing decision-making of supplementary and independent NMPs practising in the UK; all primary and secondary study designs were considered. Studies were assessed for quality and data extracted independently by two researchers, and findings synthesized using a narrative approach. RESULTS: Following duplicates exclusion, 886 titles, 349 abstracts and 40 full studies were screened. Thirty-seven were excluded leaving three for quality assessment and data extraction. While all studies reported aspects of prescribing decision-making, this was not the primary research aim for any. Studies were carried out in primary care almost exclusively among nurse prescribers (n = 67). Complex influences were evident such as experience in the role, the use of evidence-based guidelines and peer support and encouragement from doctors; these helped participants to feel more knowledgeable and confident about their prescribing decisions. Opposing influences included prioritization of experience and concern about complications over evidence base, and peer conflict. CONCLUSION: While there is a limited evidence base on NMPs' prescribing decision-making, it appears that this is complex with NMPs influenced by many and often opposing factors.


Assuntos
Tomada de Decisão Clínica , Prescrições de Medicamentos , Padrões de Prática em Enfermagem , Competência Clínica , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Guias de Prática Clínica como Assunto , Encaminhamento e Consulta , Reino Unido
12.
Patient ; 9(6): 583-590, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27170056

RESUMO

BACKGROUND: Multi-compartment compliance aids (MCAs) are repackaging systems for solid dosage form medicines, heralded by some as a solution to non-adherence but with little evidence of benefit. OBJECTIVE: The aim was to use a theoretical approach to describe the behavioural determinants impacting the use of MCAs in older people from the perspectives of the individual and health and social care providers. DESIGN: A case study investigation was conducted. SETTING: The study took place in three very sheltered housing sites in North East Scotland. SUBJECTS: Twenty residents (≥65 years) using an MCA for at least 6 months and 34 members of their care team [17 formal carers, eight general practitioners (GPs), eight pharmacists, one family member]. METHODS: Semi-structured, face-to-face interviews with items based on the Theoretical Domains Framework were conducted. Interviews were audio-recorded, transcribed and analysed thematically. RESULTS: Several behavioural determinants impacted the use of MCAs from the perspectives of the stakeholders involved. Goals of use related to promoting adherence and safety, with less emphasis on independence. Beliefs of consequences related to these goals and were considered of value, with additional consequences of concern around reduced awareness of medicines and complexities of changing medicines. There was a lack of clearly defined roles of professionals for all processes of MCA use, with evidence of blurring and gaps in roles. There were additional issues relating to capabilities of older people in using MCAs and capacity issues for pharmacy-supplied MCAs. CONCLUSIONS: Several behavioural determinants impacted the use of MCAs, and while MCAs were valued, there is a need to more clearly define, develop, implement and evaluate a model of care encompassing resident and medicines assessment, supply and ongoing review of MCAs.


Assuntos
Habitação para Idosos , Cooperação do Paciente , Idoso , Cuidadores , Feminino , Clínicos Gerais , Habitação , Humanos , Masculino , Farmacêuticos , Escócia
13.
Birth ; 42(4): 290-8, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26255973

RESUMO

BACKGROUND: Many women from socially disadvantaged groups discontinue breastfeeding in the early postnatal period before lactation is fully established. This suggests that existing health service practices do not adequately meet the breastfeeding support needs of this population. The aim of this meta-synthesis is to review the literature exploring how women from socioeconomically deprived backgrounds experience breastfeeding establishment and to identify factors associated with supportive practice. METHODS: The meta-synthesis includes qualitative studies exploring the perception of women from disadvantaged groups of in-hospital and professionally led interventions to support the establishment of breastfeeding. Searches were conducted for studies published between 1992 and 2013; after critical appraisal, eight studies were retained. RESULTS: Three overarching themes of the influences on maternal perception of the efficacy of breastfeeding support were identified. These included practical skill and knowledge of the breastfeeding process, the influence of psychological factors on perceived breastfeeding ability, and the provision of a person-centered approach to infant feeding support. CONCLUSIONS: The findings illustrate that the factors associated with supportive breastfeeding practice are extensive, complex, and interrelated. Strategies which enable mothers to gain confidence in their ability to successfully breastfeed by acquiring technical expertise, which offer positive encouragement, and which are culturally specific are more likely to be perceived as supportive by women from socially disadvantaged groups.


Assuntos
Aleitamento Materno , Cuidado Pós-Natal , Populações Vulneráveis , Aleitamento Materno/métodos , Aleitamento Materno/psicologia , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Cuidado Pós-Natal/métodos , Cuidado Pós-Natal/psicologia , Psicologia , Apoio Social , Fatores Socioeconômicos , Populações Vulneráveis/psicologia , Populações Vulneráveis/estatística & dados numéricos
14.
Acta Neuropsychiatr ; 26(4): 246-52, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25142294

RESUMO

OBJECTIVE: This study aims to document the nature and progression of the spontaneous writing impairment observed in patients with Alzheimer's disease (AD) over a 12-month period using both a cross-sectional and prospective longitudinal design. METHODS: Thirty-one minimal-moderate AD patients and 30 controls matched for age and socio-cultural background completed a simple and complex written description task at baseline. The AD patients then had follow-up assessments at 6 and 12 months. RESULTS: Cross-sectional comparisons indicated that minimal-moderate AD patients produced more semantic paraphasias, phonological paraphasias, and empty and indefinite phrases, whilst producing fewer pictorial themes, repairing fewer errors, and producing shorter and less complex sentences than controls. The two groups could not be distinguished on visual paraphasias. Longitudinal follow-up, however, suggested that visual processing deteriorates over time, where the prevalence of visual errors increased over 12 months. Discussion The findings suggest that the deterioration of writing skills observed in the spontaneous writings of AD patients shows a pattern of impairment dominated by semantic errors with a secondary impairment in phonological processing, which is later joined by a disruption of visuospatial and graphomotor processing.


Assuntos
Doença de Alzheimer/fisiopatologia , Escrita Manual , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/complicações , Estudos Transversais , Progressão da Doença , Feminino , Seguimentos , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Estudos Prospectivos , Semântica
15.
Acta Neuropsychiatr ; 25(6): 320-7, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25287871

RESUMO

OBJECTIVE: This study aims to document the nature and progression of spontaneous speech impairment suffered by patients with Alzheimer's disease (AD) over a 12-month period, using both cross-sectional and prospective longitudinal design. METHODS: Thirty one mild-moderate AD patients and 30 controls matched for age and socio-cultural background completed a simple and complex oral description task at baseline. The AD patients then underwent follow-up assessments at 6 and 12 months. RESULTS: Cross-sectional comparisons indicated that mild-moderate AD patients produced more word-finding delays (WFDs) and empty and indefinite phrases, while producing fewer pictorial themes, repairing fewer errors, responding to fewer WFDs, produce shorter and less complex phrases and produce speech with less intonational contour than controls. However, the two groups could not be distinguished on the basis of phonological paraphasias. Longitudinal follow-up, however, suggested that phonological processing deteriorates over time, where the prevalence of phonological errors increased over 12 months. Discussion Consistent with findings from neuropsychological, neuropathological and neuroimaging studies, the language deterioration shown by the AD patients shows a pattern of impairment dominated by semantic errors, which is later joined by a disruption in the phonological aspects of speech.

16.
Psychiatry Res ; 173(3): 218-27, 2009 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-19683419

RESUMO

In a study of the effects of normal and pathological aging on semantic-related brain activity, 29 patients with Alzheimer's disease (AD) and 19 controls subjects (10 young and 9 older controls) performed a version of the Pyramids and Palm Trees Test that had been adapted for use during functional magnetic resonance imaging (fMRI). Young and older controls activated the left inferior and middle frontal gyri, precuneus and superior parietal lobule. Right frontal and left temporal cortices were activated only in the young. The AD group activated only the left prefrontal and cingulate cortex. Separate analyses of high- and low-performing AD subgroups showed a similar pattern of activation in the left frontal lobe, although activiation was more widespread in low performers. High performers significantly deactivated anterior midline frontal structures, however, while low performers did not. When the older adult and AD groups were combined, there was a significant positive correlation between left frontal and parietal activation and Mini-Mental State Examination (MMSE) score (covarying for age), suggesting a disease effect. A significant negative correlation between activation in the left temporal cortex and age (covarying for MMSE score) reflected a possible age effect. These differential effects suggest that semantic activation paradigms might aid diagnosis in those cases for whom conventional assessments lack the necessary sensitivity to detect subtle changes.


Assuntos
Envelhecimento , Doença de Alzheimer/patologia , Mapeamento Encefálico , Encéfalo/fisiopatologia , Semântica , Adulto , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/fisiopatologia , Análise de Variância , Aprendizagem por Associação/fisiologia , Encéfalo/irrigação sanguínea , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Imageamento por Ressonância Magnética , Masculino , Testes Neuropsicológicos , Oxigênio/sangue , Análise de Regressão , Adulto Jovem
17.
Magn Reson Imaging ; 25(6): 848-59, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17442521

RESUMO

This functional magnetic resonance imaging (fMRI) study examined changes in brain activation after prolonged (20 weeks) and stabilized treatment with the cholinesterase inhibitor galantamine in a small group of patients with very mild Alzheimer's disease (AD). Two cognitive activation paradigms were chosen: one requiring semantic association and the other relying on attention and requiring target detection. A group of age- and education-matched healthy controls was also scanned for comparison. A modest (but not statistically significant) improvement in behavioral scores after treatment was observed in both fMRI tasks. There were brain activation increases in the semantic association task after treatment, and the differences in brain activation present in the comparison of AD patients' baseline images with those of controls were not detectable after treatment. In the target detection task, regions that were activated in the elderly controls but not in the baseline images of the AD group also showed significant activation after treatment. Overall, however, the increases were modest and might reflect the heterogeneity of clinical response to treatment in this small group. Future pharmacological fMRI studies should include clinical response as a factor in the analysis of cholinergic enhancement effects in AD patients.


Assuntos
Doença de Alzheimer/diagnóstico , Doença de Alzheimer/patologia , Mapeamento Encefálico/métodos , Encéfalo/patologia , Colinérgicos/metabolismo , Imageamento por Ressonância Magnética/métodos , Idoso , Idoso de 80 Anos ou mais , Demência/diagnóstico , Demência/patologia , Feminino , Galantamina/farmacologia , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Parassimpatomiméticos/farmacologia , Reprodutibilidade dos Testes
18.
Neuropsychologia ; 43(11): 1625-32, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16009244

RESUMO

This study examined differences in the characteristics of words produced by healthy elderly controls and by patients with Alzheimer's disease (AD) in a semantic fluency task (generating words from the categories of animals and fruit). Ninety-six AD patients (MMSE 13-29) and 40 controls matched for age and socio-cultural background completed a semantic fluency task. Length, frequency, typicality and age of acquisition (AoA) values were obtained for each word generated. In comparison with controls, AD patients generated fewer items, and their items were higher in frequency, shorter in length, more typical and earlier in AoA. Discriminant function analysis showed that AoA was the best predictor of group membership (patient/control). The mean AoA of words generated correctly classified 95% of controls and 88% of patients.


Assuntos
Envelhecimento/fisiologia , Transtornos Cognitivos/fisiopatologia , Linguagem do Esquizofrênico , Semântica , Comportamento Verbal/fisiologia , Idade de Início , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/complicações , Doença de Alzheimer/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos/estatística & dados numéricos , Medida da Produção da Fala/métodos
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