1.
Bioorg Med Chem Lett
; 14(6): 1427-31, 2004 Mar 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15006376
RESUMO
The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.