Functional status, respiratory muscle strength, and quality of life in patients with cirrhosis.

BACKGROUND: Liver diseases are responsible for metabolic disorders and loss of muscle mass and function that affect functional status and quality of life (QoL). OBJECTIVE: To compare exercise capacity, respiratory muscle strength, and QoL in liver transplant candidates with cirrhosis of the following etiologies: hepatitis C virus (HCV), hepatitis B virus (HBV), and alcoholic cirrhosis (AC). METHODS: Cross-sectional study comprising 86 patients divided into three groups: HCV (40 patients), HBV (14 patients), and AC (32 patients). Patients were evaluated using the Six-Minute Walk Test (6MWT), manometry, and the QoL questionnaire SF-36. RESULTS: The AC group showed the lowest performance in the 6MWT (meters) compared to the HBV and HCV groups (373.50 ± 50.48, 464.16 ± 32, and 475.94 ± 27.84, respectively, p=0.001). In the domains of the SF-36, the AC group had lower scores for functional capacity and physical limitations when compared to the HBV and HCV groups (p=0.001). In the comparison of respiratory muscle strength, the AC group had lower MIP (cmH2O) compared to the HBV and HCV groups (-65.54 ± 11.28, -71.61 ± 6.96, -82.44 ± 13.71, respectively, p=0.001). The MEP (cmH2O) in the AC group was also lower than in the HBV and HCV groups (65.13 ± 10.74, 82.44 ± 13.87, 83.44 ± 12.20, respectively, p=0.001). CONCLUSION: The AC group showed worse exercise capacity, respiratory muscle strength, and QoL compared to patients with HCV and HBV.

Condição funcional, força muscular respiratória e qualidade de vida em pacientes cirróticos / Functional status, respiratory muscle strength, and quality of life in patients with cirrhosis

CONTEXTUALIZAÇÃO: As doenças hepáticas são responsáveis pelas alterações metabólicas, perda da massa e função muscular que interferem na condição funcional e na qualidade de vida (QV). OBJETIVO: Comparar a capacidade ao exercício, a força muscular respiratória e a QV entre os pacientes com cirrose hepática, candidatos ao transplante de fígado, com as seguintes etiologias: hepatite vírus C (HCV), hepatite vírus B (HBV) e cirrose alcoólica (CA). MÉTODOS: Estudo transversal, composto por 86 pacientes, divididos em três grupos: HCV (40 pacientes), HBV (14 pacientes) e CA (32 pacientes). Os pacientes foram avaliados por meio do teste da caminhada de seis minutos (TC6min), manovacuometria e QV pelo questionário SF-36. RESULTADOS: O grupo CA apresentou menor distância percorrida no TC6min (metros) quando comparado com os grupos HBV e HCV (373,50±50,48; 464,16±32 e 475,94±27,84, respectivamente, p=0,001). Nos domínios do SF-36, o grupo CA apresentou menores escores na capacidade funcional e limitações por aspectos físicos quando comparado com os grupos HBV e HCV (p=0,001). Na comparação da força dos músculos respiratórios, o grupo CA apresentou menor PImáx (cmH2O) quando comparado com os grupos HBV e HCV (-65,54±11,28; -71,61±6,96; -82,44±13,71, respectivamente, p=0,001). A PEmáx (cmH2O) no grupo CA foi menor do que nos grupos HBV e HCV (65,13±10,74; 82,44±13,87; 83,44±12,20, respectivamente, p=0,001). CONCLUSÃO: O grupo CA demonstrou pior capacidade ao exercício, força muscular respiratória e QV quando comparado aos pacientes com HCV e HBV.

BACKGROUND: Liver diseases are responsible for metabolic disorders and loss of muscle mass and function that affect functional status and quality of life (QoL). OBJECTIVE: To compare exercise capacity, respiratory muscle strength, and QoL in liver transplant candidates with cirrhosis of the following etiologies: hepatitis C virus (HCV), hepatitis B virus (HBV), and alcoholic cirrhosis (AC). METHODS: Cross-sectional study comprising 86 patients divided into three groups: HCV (40 patients), HBV (14 patients), and AC (32 patients). Patients were evaluated using the Six-Minute Walk Test (6MWT), manometry, and the QoL questionnaire SF-36. RESULTS: The AC group showed the lowest performance in the 6MWT (meters) compared to the HBV and HCV groups (373.50±50.48, 464.16±32, and 475.94±27.84, respectively, p=0.001). In the domains of the SF-36, the AC group had lower scores for functional capacity and physical limitations when compared to the HBV and HCV groups (p=0.001). In the comparison of respiratory muscle strength, the AC group had lower MIP (cmH2O) compared to the HBV and HCV groups (-65.54±11.28, -71.61±6.96, -82.44±13.71, respectively, p=0.001). The MEP (cmH2O) in the AC group was also lower than in the HBV and HCV groups (65.13±10.74, 82.44±13.87, 83.44±12.20, respectively, p=0.001). CONCLUSION: The AC group showed worse exercise capacity, respiratory muscle strength, and QoL compared to patients with HCV and HBV.