RESUMO
The left ventricular mass (LVM) measurement is of major importance for renal patients, as ventricular hypertrophy is an important prognostic index. The echocardiogram of the ventricular mass is larger before than it is after hemodialysis, which can confuse data interpretation. The aim of this work is to study the influence of alterations in fluid volume on the variations in measurements of ventricular mass observed during the course of a hemodialysis. Sixteen patients with chronic renal insufficiency in hemodialysis were evaluated at the Dialysis Unit of the University Hospital-UNESP, Botucatu, São Paulo State. The left ventricular mass was calculated from echocardiograms taken before and after hemodialysis and simultaneous ultra-filtration (12 patients: UF GROUP) and before and after hemodialysis isovolemic phase with sequential ultra-filtration (10 patients: ISO GROUP). Six of these patients were submitted to measurements of left ventricular mass before and after hemodialysis in both isovolemic and simultaneous ultra-filtration procedures. In the UF group, there was significant reduction in the following parameters before and after dialysis: diastolic diameter from 54.0 +/- 6.0mm to 45.6 +/- 7.6mm; left ventricular mass from 342 +/- 114 g to 265 +/- 117 g; and its respective index (IMVE) from 214 +/- 68 g/m2 to 168 +/- 71 g/m2. The ISO group showed no statistically significant variation. The behavior of the variables of six patients submitted to both observations confirm these results. In conclusion, the variations in echocardiogram measurements of the left ventricula mass relating to hemodialysis appear to be induced by alterations of the volemic condition.
Assuntos
Volume Cardíaco/fisiologia , Ecocardiografia , Diálise Renal , Adolescente , Adulto , Idoso , Pressão Sanguínea/fisiologia , Peso Corporal/fisiologia , Brasil , Diástole/fisiologia , Feminino , Ventrículos do Coração/diagnóstico por imagem , Ventrículos do Coração/fisiopatologia , Humanos , Falência Renal Crônica/complicações , Falência Renal Crônica/fisiopatologia , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Sístole/fisiologia , Resultado do Tratamento , Ultrafiltração , Disfunção Ventricular Esquerda/complicações , Disfunção Ventricular Esquerda/fisiopatologiaRESUMO
Os autores avaliaram a prevalência da acetilaçäo da isoniazida em 75 doentes com paracoccidioidomicose. Observaram que 54,7 por cento dos doentes apresentaram fenótipo acetilador lento e 45,3 por cento rápido. Os resultados encontrados säo semelhantes aos da populaçäo geral do Sul do Brasil, sugerindo que este caráter genético näo é fator de resistência e/ou predisposiçäo à doença
