RESUMO
No disponible
Assuntos
Humanos , Feminino , Adulto , Transtornos de Deficit da Atenção e do Comportamento Disruptivo/diagnóstico , Transtornos de Ansiedade/complicações , Septo Nasal/diagnóstico por imagem , Biópsia , Perfuração do Septo Nasal/etiologia , Dermatite/tratamento farmacológico , Transtornos de Deficit da Atenção e do Comportamento Disruptivo/psicologia , Septo Nasal/patologia , Septo Nasal/cirurgia , Diagnóstico Diferencial , Terapia Combinada , Perfuração do Septo Nasal/diagnóstico por imagem , Perfuração do Septo Nasal/terapia , Aripiprazol/administração & dosagemRESUMO
No disponible
No disponible
Assuntos
Humanos , Feminino , Adulto , Siringoma/complicações , Siringoma/diagnóstico , Siringoma/terapia , Lasers/uso terapêutico , Imuno-Histoquímica/métodos , Adenoma de Glândula Sudorípara/complicações , Adenoma de Glândula Sudorípara/diagnóstico , Diagnóstico Diferencial , Derme/patologia , Células Estromais/patologia , Ácido Tricloroacético/uso terapêutico , Retinoides/uso terapêutico , Mucinoses/complicaçõesRESUMO
OBJECTIVE: To assess the presence of foreign material in the granulomatous cutaneous lesions of patients with systemic sarcoidosis. DESIGN AND SETTING: Observational study reevaluating histological specimens at a university referral hospital. PATIENTS: Sixty-five patients diagnosed as having sarcoidosis who developed granulomatous cutaneous involvement. MAIN OUTCOME MEASURES: To detect the presence of polarizable foreign particles in cutaneous biopsy specimens and to evaluate the association with clinical features of the patients. RESULTS: Granulomatous cutaneous involvement was demonstrated in 65 (15.3%) of 425 patients with systemic sarcoidosis. In 14 (22%) of the 65 patients, the cutaneous biopsy specimen showed foreign particles in polarized light. The skin lesions corresponded to 3 different clinical patterns: an admixture of papules and infiltration of previously undetected minute scars (n = 6); scar sarcoidosis (n = 4); and subcutaneous nodules (n = 4). The lesions were located most frequently in the extremities, involving the knees in 10 patients. CONCLUSIONS: The presence of polarizable foreign body material in granulomatous cutaneous lesions is not infrequent in patients with systemic sarcoidosis. Inoculation of foreign matter from a previous inapparent minor trauma may induce granuloma formation in individuals with sarcoidosis.
Assuntos
Granuloma de Corpo Estranho/patologia , Sarcoidose/patologia , Dermatopatias/patologia , Pele/patologia , Adulto , Idoso , Biópsia , Cicatriz/patologia , Diagnóstico Diferencial , Feminino , Granuloma de Corpo Estranho/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Sarcoidose/diagnósticoRESUMO
BACKGROUND: A significant proportion of multiple sclerosis patients develop cutaneous reactions by interferon beta 1b (IFN-beta). The am of this study was to describe clinically and histologically the cutaneous reactions by IFN-beta. PATIENTS AND METHODS: A series of 92 patients with multiple sclerosis in treatment with IFN-beta was followed. Cutaneous biopsy was performed in cases with persistent lesions. RESULTS: 9 out of 92 patients presented eritematous plaques, 4 cutaneous ulcers and 1 sclerodermiform plaques. Vascular thrombosis was demonstrated in 2 cases. CONCLUSIONS: In patients with multiple sclerosis treated with IFN-beta the persistent skin lesions are more frequent in female patients. Generally is not necessary to stop the treatment.
