Assuntos
Coccidioidomicose , Linfadenite Histiocítica Necrosante , Linfonodos/patologia , Nódulo Pulmonar Solitário , Síndrome de Sweet , Adulto , Anticorpos Antifúngicos/sangue , Coccidioides/imunologia , Coccidioides/isolamento & purificação , Coccidioidomicose/sangue , Coccidioidomicose/microbiologia , Coccidioidomicose/fisiopatologia , Coccidioidomicose/terapia , Feminino , Linfadenite Histiocítica Necrosante/diagnóstico , Linfadenite Histiocítica Necrosante/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Nódulo Pulmonar Solitário/diagnóstico por imagem , Nódulo Pulmonar Solitário/microbiologia , Nódulo Pulmonar Solitário/fisiopatologia , Síndrome de Sweet/diagnóstico , Síndrome de Sweet/etiologia , Síndrome de Sweet/microbiologia , Resultado do Tratamento , Conduta ExpectanteRESUMO
There is a well-known association between vitamin K deficiency and haemorrhagic events including gastrointestinal bleeding. There is also a well-known association between both poor dietary intake of vitamin K and chronic antibiotic use and the development of vitamin K deficiency. Although the medical literature notes that cephalosporin antibiotics have a propensity to cause vitamin K deficiency due to the molecular structure of the medications and their ability to suppress the synthesis of clotting factors, there are other antibiotics that have also been implicated in the development of vitamin K deficiency. There are very few reports of trimethoprim/sulfamethoxazole causing vitamin K deficiency and further leading to bleeding episodes. We present such a case and discuss the risk factors leading to such complications.