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J Org Chem ; 89(11): 7913-7926, 2024 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-38778786

RESUMO

A one-pot procedure for the oxidative amidation of aldehydes via the in situ generation of reactive nitrile imine (NI) intermediates has been developed. Distinct from our progenitor processes, mechanistic and control experiments revealed that the NI undergoes rapid oxidation to an acyl diazene species, which then facilitates N-acylation of an amine. A range of substrates have been explored, including application in the synthesis of pharmaceutically relevant compounds.

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