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1.
Health Sci Rep ; 2(1): e95, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30697594

RESUMO

OBJECTIVES: The current 2017 ESC/EACTS guidelines recommend transcatheter aortic valve implantations (TAVIs) as the therapy of choice for inoperable patients with severe symptomatic aortic stenosis. Most of the TAVIs worldwide are performed under general anaesthesia (GA). Although conscious sedation (CS) concepts are increasingly applied in Europe, it is still a matter of debate which concept is associated with highest amount of safety for this high-risk patient population. The aim of this single center, before-and-after study was to investigate feasibility and safety of CS compared with GA with respect to peri-procedural complications and 30-day mortality in patients scheduled for transfemoral TAVI (TF-TAVI). METHODS: From March 2012 until September 2014, patients scheduled for the TF-TAVI procedure were included in a prospective, observational manner. From the 200 patients finally included, 107 procedures were performed under GA, using either an endotracheal tube or a laryngeal mask, and balanced anaesthesia. CS was performed in 93 patients using low-dose propofol and remifentanil. RESULTS: Conversion to GA was needed 4 times due to procedural-related complications (4.3%), in one patient due to ongoing agitation (1.1%). The CS-group showed significantly shorter key time courses: anaesthesia time (105 [95-120] minutes vs 115 [105-140] minutes, P-value = 0.009, Mann-Whitney-U-test) and length of stay in the intensive care unit (1.6 [1.0-1.5] d vs 2.1 [1.0-2.0] d, P-value = 0.002, Mann-Whitney-U-test). The lowest mean arterial pressure was significantly higher in the CS-group compared with the GA-group (74.3 mmHg vs 55.2 mmHg, P-value <0.0001, t-test). CS was associated with less requirements of norepinephrine (0.1 µg/kg vs 2.3 µg/kg, P-value <0.0001, Mann-Whitney-U-test). CONCLUSIONS: Our single-center data demonstrate that CS is a feasible and safe alternative, especially with respect to a higher degree of intra-procedural haemodynamic stability, and a reduced length of stay in the intensive care unit.

3.
Anesthesiology ; 127(6): 918-933, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-28872484

RESUMO

BACKGROUND: Ischemic myocardial damage accompanying coronary artery bypass graft surgery remains a clinical challenge. We investigated whether xenon anesthesia could limit myocardial damage in coronary artery bypass graft surgery patients, as has been reported for animal ischemia models. METHODS: In 17 university hospitals in France, Germany, Italy, and The Netherlands, low-risk elective, on-pump coronary artery bypass graft surgery patients were randomized to receive xenon, sevoflurane, or propofol-based total intravenous anesthesia for anesthesia maintenance. The primary outcome was the cardiac troponin I concentration in the blood 24 h postsurgery. The noninferiority margin for the mean difference in cardiac troponin I release between the xenon and sevoflurane groups was less than 0.15 ng/ml. Secondary outcomes were the safety and feasibility of xenon anesthesia. RESULTS: The first patient included at each center received xenon anesthesia for practical reasons. For all other patients, anesthesia maintenance was randomized (intention-to-treat: n = 492; per-protocol/without major protocol deviation: n = 446). Median 24-h postoperative cardiac troponin I concentrations (ng/ml [interquartile range]) were 1.14 [0.76 to 2.10] with xenon, 1.30 [0.78 to 2.67] with sevoflurane, and 1.48 [0.94 to 2.78] with total intravenous anesthesia [per-protocol]). The mean difference in cardiac troponin I release between xenon and sevoflurane was -0.09 ng/ml (95% CI, -0.30 to 0.11; per-protocol: P = 0.02). Postoperative cardiac troponin I release was significantly less with xenon than with total intravenous anesthesia (intention-to-treat: P = 0.05; per-protocol: P = 0.02). Perioperative variables and postoperative outcomes were comparable across all groups, with no safety concerns. CONCLUSIONS: In postoperative cardiac troponin I release, xenon was noninferior to sevoflurane in low-risk, on-pump coronary artery bypass graft surgery patients. Only with xenon was cardiac troponin I release less than with total intravenous anesthesia. Xenon anesthesia appeared safe and feasible.


Assuntos
Anestesia Intravenosa , Ponte de Artéria Coronária/tendências , Internacionalidade , Éteres Metílicos/administração & dosagem , Troponina I/sangue , Xenônio/administração & dosagem , Idoso , Anestésicos Inalatórios/administração & dosagem , Biomarcadores/sangue , Ponte de Artéria Coronária/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/sangue , Complicações Pós-Operatórias/prevenção & controle , Estudos Prospectivos , Sevoflurano , Método Simples-Cego , Resultado do Tratamento
4.
Artigo em Alemão | MEDLINE | ID: mdl-21894593

RESUMO

Supraglottic airway devices are developed with increasing frequency following the overwhelming success of the laryngeal mask airway (LMA). In contrast to the first generation devices such as the 'classic' LMA and the laryngeal tube second generation devices usually offer an oesophageal drainage tube and/or an improved oropharyngeal leak pressure during positive pressure ventilation such as the laryngeal mask ProSeal and the laryngeal tube S. Recently the disposable versions of these supraglottic airway devices and the novel I-Gel mask have gained increasing interest. Both the LMA and the PLMA have been shown to be perfectly suitable for routine anaesthesia and emergency airway management. While the lacking protection against aspiration is still considered a major limitation of the LMA, the value of airway devices with an oesophageal drainage tube in this respect remains untermined at present.


Assuntos
Manuseio das Vias Aéreas/instrumentação , Glote/anatomia & histologia , Manuseio das Vias Aéreas/métodos , Anestesia/métodos , Contraindicações , Humanos , Intubação Intratraqueal/métodos , Máscaras Laríngeas/efeitos adversos , Obesidade/complicações , Respiração Artificial/instrumentação , Respiração Artificial/métodos , Aspiração Respiratória
5.
Eur J Anaesthesiol ; 26(8): 648-53, 2009 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19487950

RESUMO

BACKGROUND AND OBJECTIVE: Intravenously administered paracetamol is an effective analgesic in postoperative pain management. However, there is a lack of data on the effect of intravenous (i.v.) paracetamol on pain following soft tissue surgery. METHODS: Eighty-seven patients undergoing elective breast surgery with total i.v. anaesthesia (propofol/remifentanil) were randomized to three groups. Group para received 1 g i.v. paracetamol 20 min before and 4, 10 and 16 h after the end of the operation. Group meta and plac received 1 g i.v. metamizol or placebo, respectively, scheduled at the same time points. All patients had access to i.v. morphine on demand to achieve adequate pain relief. RESULTS: No significant difference in total morphine consumption between groups was detectable. The proportion of patients who did not receive any morphine in the postoperative period was significantly higher in group para (42%) than in group plac (4%). Ambulation was significantly (P < 0.05) earlier in group para (4.0 +/- 0.2 h) than in groups meta (4.6 +/- 0.2 h) and plac (5.5 +/- 1.0 h). No differences were observed between groups meta and plac. There were no differences between groups with regard to incidence of postoperative nausea and vomiting or changes in vigilance. CONCLUSION: Neither i.v. paracetamol nor i.v. metamizol provided a significant reduction in total postoperative morphine consumption compared with placebo in the management of postoperative pain after elective breast surgery. Administration of paracetamol resulted in a significant reduction in the number of patients needing opioid analgesics to achieve adequate postoperative pain relief.


Assuntos
Acetaminofen/uso terapêutico , Analgésicos não Narcóticos/uso terapêutico , Anti-Inflamatórios não Esteroides/uso terapêutico , Mama/cirurgia , Dipirona/uso terapêutico , Dor Pós-Operatória/tratamento farmacológico , Acetaminofen/administração & dosagem , Idoso , Analgésicos não Narcóticos/administração & dosagem , Analgésicos Opioides/administração & dosagem , Analgésicos Opioides/uso terapêutico , Anti-Inflamatórios não Esteroides/administração & dosagem , Dipirona/administração & dosagem , Método Duplo-Cego , Feminino , Humanos , Injeções Intravenosas , Masculino , Pessoa de Meia-Idade , Morfina/administração & dosagem , Morfina/uso terapêutico , Náusea e Vômito Pós-Operatórios/tratamento farmacológico , Resultado do Tratamento
6.
Eur J Anaesthesiol ; 26(9): 730-5, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19373095

RESUMO

BACKGROUND AND OBJECTIVE: EasyTube (EZT), ProSeal laryngeal mask airway (PLMA), and Laryngeal tube S II (LTS II) have recently been introduced as supraglottic airway devices and have been proposed as emergency airway alternatives. The purpose of this study was to compare the performance of the three devices, if used by anaesthesiologists without extensive hands-on training, with the endotracheal tube during routine surgical procedures. METHODS: After informed consent, 88 ASA I-II patients scheduled for routine minor surgery were randomly allocated to EZT (n=22), PLMA (n=22), and LTS II (n=22) groups and the endotracheal tube (n=22) group, respectively. Overall success rates, insertion times, cuff pressures, and resulting airway leak pressures as well as subjective assessment of handling were determined. RESULTS: Overall insertion success rate of the EZT, PLMA, LTS II, and endotracheal tube was 14 out of 22 (64%), 20 out of 22 (91%), 21 out of 22 (96%), and 21 out of 22 (96%), respectively. Time to first successful ventilation with the EZT was significantly (P<0.05) longer than that with PLMA, LTS II, and endotracheal tube [median (minimum-maximum): 56 (27-150), 25 (12-70), 24 (11-150), and 20 (8-74) s, respectively]. The lowest airway leak pressure could be observed with the EZT [median (minimum-maximum), 19 (9-40) cmH2O] and the highest airway leak pressure with the LTS II [median (minimum-maximum), 40 (22-40) cmH2O]. Subjective assessment of handling was significantly (P<0.05) poorer in the EZT group compared with PLMA, LTS II, and endotracheal tube groups, respectively. CONCLUSION: In contrast to the EZT, both PLMA and LTS II proved to be suitable for routine airway management by anaesthesiologists without extensive hands-on device training.


Assuntos
Anestesia por Inalação/instrumentação , Procedimentos Cirúrgicos Eletivos/instrumentação , Máscaras Laríngeas , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anestesia por Inalação/métodos , Pressão Sanguínea/fisiologia , Competência Clínica , Eletroencefalografia/métodos , Desenho de Equipamento , Frequência Cardíaca/fisiologia , Humanos , Máscaras Laríngeas/efeitos adversos , Pessoa de Meia-Idade , Pressão , Testes de Função Respiratória , Adulto Jovem
7.
Anesthesiology ; 104(4): 635-43, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16571956

RESUMO

BACKGROUND: Baseline low-to-high frequency ratio (LF/HF) of heart rate variability predicted hypotension after subarachnoid block (SAB). LF/HF-guided treatment of hypotension with vasopressors or colloids was investigated. METHODS: In 80 women scheduled to undergo cesarean delivery during SAB, LF/HF and systolic blood pressure (SBP) were analyzed. Patients were randomly assigned to a control group (n = 40) or a treatment group (n = 40). Control patients were assigned by their baseline LF/HF to one of two subgroups: LF/HF less than 2.5 or LF/HF greater than 2.5. Treatment patients with baseline LF/HF greater than 2.5 were treated with vasopressor infusion right after SAB (n = 20) or colloid prehydration until LF/HF decreased below 2.5 (n = 20). The incidences of hypotension (SBP < 80 mmHg) and hypertension (SBP > 140 mmHg) were investigated. LF/HF is presented as median and range, and SBP is presented as mean +/- SD. RESULTS: Three of 17 control patients with low baseline LF/HF (1.7 [1.3/1.8]) demonstrated hypotension, and mean SBP remained stable (lowest SBP = 105 +/- 14 mmHg). In contrast, 20 of 23 control patients with high baseline LF/HF (3.8 [3.3/4.8]; P < 0.0001 vs. low baseline LF/HF) demonstrated hypotension after SAB: lowest SBP = 78 +/- 15 mmHg (P < 0.0001 vs. lowest SBP of control group with low baseline LF/HF). LF/HF-guided vasopressor therapy prevented hypotension in 19 of 20 patients: baseline SBP = 123 +/- 15 mmHg, lowest SBP = 116 +/- 17 mmHg. Mean prophylactic colloid infusion of 1,275 +/- 250 ml reduced elevated baseline LF/HF from 5.4 (4.1/7.5) to 1.3 (0.8/1.59) (P < 0.0001). Hypotension was prevented in 17 of 20 patients: baseline SBP = 115 +/- 13 mmHg, lowest SBP = 104 +/- 19 mmHg. No hypertensive episode was recognized. CONCLUSIONS: LF/HF may be a tool to guide prophylactic therapy of patients at high risk for hypotension after SAB. Vasopressor therapy tended to be more effective compared with colloid prehydration.


Assuntos
Anestesia Obstétrica/efeitos adversos , Raquianestesia/efeitos adversos , Frequência Cardíaca , Hipotensão/prevenção & controle , Adulto , Cesárea , Coloides , Feminino , Hidratação , Humanos , Hipotensão/etiologia , Gravidez , Estudos Prospectivos , Sístole
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