Unveiling the MIL-53(Al) MOF: Tuning Photoluminescence and Structural Properties via Volatile Organic Compounds Interactions.

MIL-53(Al) is a metal-organic framework (MOF) with unique properties, including structural flexibility, thermal stability, and luminescence. Its ability to adsorb volatile organic compounds (VOCs) and water vapor makes it a promising platform for sensing applications. This study investigated the adsorption mechanism of MIL-53(Al) with different VOCs, including ketones, alcohols, aromatics, and water molecules, focusing on structural transformations due to pore size variation and photoluminescence properties. The reported results assess MIL-53(Al) selectivity towards different VOCs and provide insights into their fundamental properties and potential applications in sensing.

A novel method to assess copy number variations in melanocytic neoplasms: Droplet digital PCR for precise quantitation of MYC and MYB genes.

INTRODUCTION: While most melanocytic neoplasms can be classified as either benign or malignant by histopathology alone, ancillary molecular diagnostic tests can be necessary to establish the correct diagnosis in challenging cases. Currently, the detection of copy number variations (CNVs) by fluorescence in situ hybridization and chromosomal microarray (CMA) are the most popular methods, but remain expensive and inaccessible. We aim to develop a relatively inexpensive, fast, and accessible molecular assay to detect CNVs relevant to melanoma using droplet digital polymerase chain reaction (ddPCR) technology. METHODS: In this proof-of-concept study, we evaluated CNVs in MYC and MYB genes from 73 cases of benign nevi, borderline melanocytic lesions, and primary and metastatic melanoma at our institution from 2015 to 2022. A multiplexed ddPCR assay and CMA were performed on each sample, and the results were compared. RESULTS: Concordance analysis of ddPCR with CMA for quantification of MYC and MYB CNVs revealed a sensitivity and specificity of 89% and 86% for MYC and 83% and 74% for MYB, respectively. CONCLUSION: We demonstrate the first use of a multiplexed ddPCR assay to identify CNVs in melanocytic neoplasms. With further improvement and validation, ddPCR may represent a low-cost and rapid tool to aid in the diagnosis of histopathologically ambiguous melanocytic tumors.

COVID-19: Financial Stress and Well-Being in Families.

In all areas of knowledge, research has shown the devastating effects of COVID-19, and the impact on families' financial stress and well-being is one of them. Crises are predictors of families' financial stress as they produce changes in their income and negative feelings, such as fear and demotivation, which affect well-being. This study analyses the financial and social impact of COVID-19 on families, supported by the ABCE-WB model, with data collection being the result of snowball sampling. The results obtained allow the conclusion that the current pandemic crisis has caused financial stress in families, to a greater or lesser degree, and caused feelings of fear and demotivation as consequences of the general lockdown. The empirical evidence also shows that these effects are positively associated with the perception of their level of well-being. The contribution of the study lies in corroborating the model used. Final considerations are presented together with the limitations and suggestions for future research.

Design of New Dispersants Using Machine Learning and Visual Analytics.

Artificial intelligence (AI) is an emerging technology that is revolutionizing the discovery of new materials. One key application of AI is virtual screening of chemical libraries, which enables the accelerated discovery of materials with desired properties. In this study, we developed computational models to predict the dispersancy efficiency of oil and lubricant additives, a critical property in their design that can be estimated through a quantity named blotter spot. We propose a comprehensive approach that combines machine learning techniques with visual analytics strategies in an interactive tool that supports domain experts' decision-making. We evaluated the proposed models quantitatively and illustrated their benefits through a case study. Specifically, we analyzed a series of virtual polyisobutylene succinimide (PIBSI) molecules derived from a known reference substrate. Our best-performing probabilistic model was Bayesian Additive Regression Trees (BART), which achieved a mean absolute error of 5.50±0.34 and a root mean square error of 7.56±0.47, as estimated through 5-fold cross-validation. To facilitate future research, we have made the dataset, including the potential dispersants used for modeling, publicly available. Our approach can help accelerate the discovery of new oil and lubricant additives, and our interactive tool can aid domain experts in making informed decisions based on blotter spot and other key properties.

Diboron reagents in the deoxygenation of nitrones.

B2nep2 efficiently promotes the N-O cleavage of nitrones to form imines in very high yields via a simple, efficient, sustainable, functional group tolerant and scalable protocol. The reaction occurs in the absence of additives through a concerted mechanism. We demonstrated that DMPO and TEMPO, typically used as radical traps, are also deoxygenated by diboron reagents, which demonstrates their limitation as mechanistic probes.

Morphological, phylogenetic, and genomic evidence reveals the causal agent of thread blight disease of cacao in Peru is a new species of Marasmius in the section Neosessiles, Marasmius infestans sp. nov.

The thread blight disease (TBD) of cacao ( Theobroma cacao) in the department of Amazonas, Peru was recently reported to be caused by Marasmius tenuissimus (sect. Neosessiles). This same species is known to be the main causal agent of TBD in West Africa. However, some morphological characteristics, such as the presence of rhizomorphs, the almost exclusively white color, and pileus sizes less than 5 mm, among others, differ to the description of M. tenuissimus. Therefore, we aimed to conduct a taxonomic revision of the cacao-TBD causal agent in Peru, by using thorough micro and macro morphological, phylogenetic, and nuclear and mitochondrial genomic approaches. We showed that the causal agent of TBD of cacao in Amazonas, Peru, belongs to a new species, Marasmius infestans sp. nov. This study enriches our knowledge of species in the sect. Neosessiles, and strongly suggests that the M. tenuissimus species complex is highly diverse.

Implementation and Assessment of Lung Ultrasound Training Curriculum for Physiotherapists With a Focus on Image Acquisition and Calculation of an Aeration Score.

Described here is the implementation of a lung ultrasound course for physiotherapists focused on the acquisition and retention of knowledge and skills. Initially, we provided online lectures in a virtual learning environment (VLE), in which we taught the semiquantification of edema through a lung ultrasound score (LUS). Afterward, the physiotherapists participated in face-to-face lectures (which resumed the online lectures), followed by hands-on training and simulation with ultrasound. We assessed knowledge acquisition through a multiple-choice test with 30 questions (totaling 10 points). The test was applied before accessing the VLE (pre-VLE), before the face-to-face course and at its end (pre- and post-course). Physiotherapists collected actual patients' ultrasound scans, which were uploaded to the VLE and assessed by three supervisors, who performed a consensus LUS calculation and gave virtual written feedback. Thirteen physiotherapists collected 59 exams. The test results were 3.60 ± 1.58 (pre-VLE), 5.94 ± 1.45 (pre-course) and 8.50 ± 0.71 (post-course), with p < 0.001 for all. The intraclass correlation coefficient for LUS between physiotherapists and supervisors was 0.814 (p < 0.001), with moderate-to-weak agreement for LUS of the lung apical, median and basal zones, with κ = 0.455.334, and 0.417 (p < 0.001 for all). Trainees were found to have increased short-term acquisition and retention of knowledge and skills, with a good intraclass correlation coefficient between them and the consensus of supervisors for the LUS of actual patients.

What exists in academia on work stress in accounting professionals: a bibliometric analysis.

This study aims to fill a gap in the literature by conducting the scientific and bibliometric mapping of work stress in accounting professionals, using a methodological trilogy that contributes to this topic, namely the application of the ROC curve, Prisma and R bibliometric tools. Through the analysis of a sample of 103 articles, it was found that, in order to avoid and/or overcome the levels of stress in accountants, the following factors should be taken into account: (1) a high engagement with work, (2) reduced self-efficacy perception in the decision-making process, (3) adverse consequences in the management process, and (4) high-stress levels embedded in the individual's personality. Thus, it will be necessary for the accountant to apply strategies and change the way he/she works and perceives the work, avoiding stress levels and irreversible health damage. In addition, the importance of resilience in the professional context and mindfulness may prevent high levels of stress and maybe the subject of future research.

Bibliometric review about eco-cites and urban sustainable development: trend topics.

The world is undergoing exponential urbanization, with consequences for society in general, both for cities and people, with serious economic, social and environmental implications. Therefore, it is crucial to reconsider urban models of cities, to ensure global, long-term sustainability. Numerous researchers have argued that one of these models involves eco-city projects, and this study aims to carry out a systematic review of the literature on this topic, through bibliometrics. To do so, the Smarter, Prisma and Vantage Point methods were used, reflecting the originality of the study. The results obtained show that China has aroused researchers' interest regarding its eco-city projects, with most studies being empirical, and so this study complements them. The main contribution of this research lies in identifying the keywords most used by authors, these being eco-cities, sustainable cities (cluster 1) and eco-cities, China, sustainable urban development and eco-cycle model (cluster 2). Finally, implications for theory and practice are presented, together with suggestions for future research.

Digital transformation shaping structural pillars for academic entrepreneurship: A framework proposal and research agenda.

Digital technology always accelerates change, altering organisations culturally, socially and technically. These modifications are known as "digital transformation" (DT). On a much greater scale than DT, the world was changed in 2020 by the COVID-19 pandemic, which re-organised society in the way of thinking, acting, producing, consuming and creating new business. Higher Education Institutions (HEIs) were no different, since these institutions had to make changes to the student-lecturer interaction; teaching-learning, where DT had a relevant role, above all in academic entrepreneurship. Therefore, this study aims to propose a framework showing the structural pillars of the link between digital transformation (DT) and academic entrepreneurship (AC) (DT-AC Framework). This framework identifies the new patterns, methods, skills and other discoveries in aspects such as management, information systems and culture sciences. The intention is not to analyse how the COVID-19 pandemic imposed global structural changes, but because of it, lecturers and students found their DT accelerated and intensified, and so it is necessary to investigate the pillars supporting academic entrepreneurship. The results show that DT was already emerging as a basic element of academic entrepreneurship before the pandemic, but the process has speeded up. This bibliometric study indicates the structural pillars that support entrepreneurship following the Covid19 pandemic, as created from DT in universities, providing an extensive systematic review that indicates the cause and effect of the academic entrepreneurship process.

Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes.

Although secondary metabolites are typically associated with competitive or pathogenic interactions, the high bioactivity of endophytic fungi in the Xylariales, coupled with their abundance and broad host ranges spanning all lineages of land plants and lichens, suggests that enhanced secondary metabolism might facilitate symbioses with phylogenetically diverse hosts. Here, we examined secondary metabolite gene clusters (SMGCs) across 96 Xylariales genomes in two clades (Xylariaceae s.l. and Hypoxylaceae), including 88 newly sequenced genomes of endophytes and closely related saprotrophs and pathogens. We paired genomic data with extensive metadata on endophyte hosts and substrates, enabling us to examine genomic factors related to the breadth of symbiotic interactions and ecological roles. All genomes contain hyperabundant SMGCs; however, Xylariaceae have increased numbers of gene duplications, horizontal gene transfers (HGTs) and SMGCs. Enhanced metabolic diversity of endophytes is associated with a greater diversity of hosts and increased capacity for lignocellulose decomposition. Our results suggest that, as host and substrate generalists, Xylariaceae endophytes experience greater selection to diversify SMGCs compared with more ecologically specialised Hypoxylaceae species. Overall, our results provide new evidence that SMGCs may facilitate symbiosis with phylogenetically diverse hosts, highlighting the importance of microbial symbioses to drive fungal metabolic diversity.

Coupling of thiols and aromatic halides promoted by diboron derived super electron donors.

We have proven that pyridine-boryl complexes can be used as superelectron donors to promote the coupling of thiols and aromatic halides through a SRN1 mechanism. The reaction is efficient for a broad substrate scope, tolerating heterocycles including pyridines, enolizable or reducible functional groups. The method has been applied to intermediates in drug synthesis as well as interesting functionalized polythioethers through a controlled and consecutive intramolecular electron transfer process.

Implementing healthcare professionals' training during COVID-19: a pre and post-test design for simulation training.

BACKGROUND: Coronavirus disease-19 (COVID-19) has imposed a new reality that presents several challenges for healthcare professionals. The main challenge has been the lack of proper training in relation to an unknown disease. OBJECTIVE: To investigate healthcare professionals' acquisition of knowledge of a new airway management protocol for COVID-19 through their participation in simulation training. DESIGN AND SETTING: Pre and post-test study with purpose sampling, carried out in a tertiary-level hospital in the city of Campinas, state of São Paulo, Brazil. METHODS: This was a cross-sectional pre and post-test intervention among healthcare professionals working in the intensive care unit and emergency department of a large hospital. The training was carried out using an in situ simulation scenario and the participants answered pre and post-tests consisting of a 20-item questionnaire about the new protocol. RESULTS: The paired-sample t test demonstrated that there was a significant increase in test score (t = -19.06; P < 0.001), from before the training (M = 8.62; standard deviation, SD = 3.53) to after the simulation training (M = 17.02; SD = 1.76). CONCLUSIONS: The simulated training had a positive impact on the healthcare professionals' acquisition of the COVID-19 protocol. We also demonstrated that in situ simulation training was an efficient tool for implementing new protocols, thus bringing benefits to healthcare systems, professionals and patients.

Systematic Review of Integration and Radicalization Prevention Programs for Migrants in the US, Canada, and Europe.

Background: International migration processes are some of the most important events of our time. Migrating implies a broad range of factors that affect integration, and which may be linked to radicalization. Host countries use different methods for the integration of migrants. The aim of this systematic review is to analyze intervention programs that aim at promoting social integration and preventing the radicalization of migrants, with the objective of studying actions carried out in the US, Canada, and Europe to this effect. Method: Worldwide known bibliographic databases (PsyCINFO, Sociological Abstracts, Psycarticles, Psychology Database, Medline, SCOPUS, and Google Scholar) were used to search studies published before January 2019 and which analyzed integration or radicalization prevention programs with migrants. Results: A total of 601 studies were screened, from which 18 met the inclusion criteria. The analysis of programs addressed to migrant women points to a decrease in loneliness and depression and an increase of migrants' perception of social support and self-esteem. Programs carried out in schools and families improve children's knowledge of their culture and that of others, increase their feelings of inclusion, and reduce their aggressiveness, stress, and anxiety. Language programs promote communication and employment search, as well as improve migrants' quality of life. One of the most effective activities included in these programs is to connect recently arrived migrants with local population and/or long-term residents. The latter act as mentors and teachers, helping recently arrived migrants understand resources and to be more integrated in the new country, as well as reducing discrimination from the local population. Conclusions: The review concluded the importance of intervention programs for integration, migrants' quality of life, prevention of extreme behaviors, and intercultural cohabitation. Future programs must be more detailed regarding participants' information and carry out more comprehensive assessments.

La competencia emocional como predictora de la felicidad en trabajadores sociales / Emotional competence as a predictor of happiness in social workers

Resumen Los trabajadores sociales tienen unas elevadas exigencias laborales como consecuencia, entre otros factores, de la excesiva burocratización de las organizaciones de servicios sociales. Ante esta realidad, durante su proceso formativo, los estudiantes de trabajo social deben desarrollar competencias emocionales para hacer frente a estas demandas profesionales que pueden afectar a su bienestar y rendimiento laboral. Se realizó un estudio descriptivo y correlacional de corte transversal del que participaron 187 estudiantes del primer y segundo curso (n = 105 y n = 82, respectivamente) de Trabajo Social de la Universidad de Málaga (España). El 89.30 % eran mujeres y la edad promedio fue de 20.38 años (DT = 3.35). Se desarrolló un modelo de regresión lineal múltiple para evaluar el papel predictor de la inteligencia emocional (atención emocional, claridad emocional y reparación de las emociones) sobre la felicidad subjetiva percibida en estudiantes de trabajo social. La claridad emocional y la reparación de las emociones fueron predictores significativos positivos de la felicidad subjetiva, mientras que la atención emocional fue un predictor significativo negativo. Los estudiantes y futuros trabajadores sociales tienen que entender y manejar sus estados emocionales, de tal manera que les permita tanto afrontar sus propias frustraciones como constituirse en referentes de los usuarios para imponerse a sus dificultades. Se corrobora la necesidad de fomentar la inteligencia emocional entre los estudiantes y futuros trabajadores sociales, ya que esto constituye un factor de protección que puede aumentar su bienestar y concretamente, su felicidad subjetiva. Las experiencias de afecto negativas que sufren los trabajadores sociales demandan planes de estudio en los que se fomente la inteligencia emocional.

Abstract As a result of the excessive bureaucratization of social service organizations, among other factors, social workers have many job responsibilities (López & Chaparro, 2006; Montagud, 2016). Social workers suffer negative experiences and a high psychosocial risk which affect their well-being and work performance (i. e., emotional fatigue, job dissatisfaction, mental overload, burnout, decrease in happiness, ethical conflicts) (Bunce, Lonsdale, King, Childs, & Bennie, 2019; Caravaca, Carrión, & Pastor, 2018; Grootegoed & Smith, 2018; Prada-Ospina, 2019; Sabater, De Armas, & Cabezas, 2019; Urien, Díez, & Osca, 2019; Vallellano & Rubio-Valdehita, 2018). Given this reality, it is very important that Social Work students develop, during their training process, emotional competencies to cope with such professional demands (Bedoya-Gallego, Buitrago-Duque, & Vanegas-Arbeláez, 2019; Stanley & Bhuvaneswari, 2016). The characteristics of the job require knowledge of the mechanisms that influence the welfare of Social Work students in order to incorporate specific training strategies into teaching plans that prepare them to face the high work demands that can affect their welfare and performance (Blakemore & Agllias, 2019; Borrego-Alés, Vázquez-Aguado, & Orgambídez-Ramos, 2020; Fernández-Berrocal & Extremera, 2009). Despite the considerable shortage of research about the implications of emotional intelligence in the field of Social Work, emotional competence has proven to be essential to explain the personal well-being of students and social intervention professionals, characterized by a high burden of work and high rates of psychological distress and burnout (Bae et al., 2020; Esteban, 2014; Mikulic, Crespi, & Radusky, 2015). A descriptive and correlational cross-sectional study was carried out. 187 students of first (n = 105) and second year (n = 82) of the University of Malaga´s Social Work Degree (Spain) participated. 89.30 % of them was women and the average age was 20.38 years (SD = 3.35). A multiple linear regression model evaluated the predictive role of emotional intelligence (attention, clarity and emotional repair) on the subjective happiness perceived in Social Work students. Emotional clarity and emotional repair were significant positive predictors of subjective happiness, while emotional attention was a significant negative predictor. Of the three independent variables, emotional repair was positioned as the strongest predictor of the perception of subjective happiness. This fact corroborates that emotional repair is especially important to predict the levels of subjective happiness and life satisfaction of university students (Cejudo, López-Delgado, & Rubio, 2016; Extremera, Salguero, & Fernández-Berrocal, 2011). High levels of emotional repair are essential for proper psychological functioning and mental health. In this sense, people tend to develop pleasant activities that distract them and therefore contribute to their happiness (Guerra-Bustamante, León-del-Barco, Yuste-Tosina, López-Ramos, & Mendo-Lázaro, 2019). Individuals who can clearly identify their emotions and believe that they can repair their negative moods minimize the impact of stressful events and generate more positive emotions (Extremera et al., 2011). In social workers, emotions can be understood both as a dynamic resource, whose research can protect professionals and users, and as patterns of organizational and professional relationships, in which emotional states are constituted as phenomena that can be managed and controlled during professional practice (O'Connor, 2020). The need to foster emotional intelligence among students and future social workers is confirmed. It constitutes a protective factor that can increase their well-being and, specifically, their subjective happiness. The negative experiences of affection that social workers suffer demand curricula that promote emotional intelligence. The students and future social workers have to understand and manage their emotional states. It allows them both to face their own frustrations and to become referents for the users when they overcome their difficulties.

Implementing healthcare professionals' training during COVID-19: a pre and post-test design for simulation training

ABSTRACT BACKGROUND: Coronavirus disease-19 (COVID-19) has imposed a new reality that presents several challenges for healthcare professionals. The main challenge has been the lack of proper training in relation to an unknown disease. OBJECTIVE: To investigate healthcare professionals' acquisition of knowledge of a new airway management protocol for COVID-19 through their participation in simulation training. DESIGN AND SETTING: Pre and post-test study with purpose sampling, carried out in a tertiary-level hospital in the city of Campinas, state of São Paulo, Brazil. METHODS: This was a cross-sectional pre and post-test intervention among healthcare professionals working in the intensive care unit and emergency department of a large hospital. The training was carried out using an in situ simulation scenario and the participants answered pre and post-tests consisting of a 20-item questionnaire about the new protocol. RESULTS: The paired-sample t test demonstrated that there was a significant increase in test score (t = −19.06; P < 0.001), from before the training (M = 8.62; standard deviation, SD = 3.53) to after the simulation training (M = 17.02; SD = 1.76). CONCLUSIONS: The simulated training had a positive impact on the healthcare professionals' acquisition of the COVID-19 protocol. We also demonstrated that in situ simulation training was an efficient tool for implementing new protocols, thus bringing benefits to healthcare systems, professionals and patients.

Discrimination and Psychosocial Well-Being of Migrants in Spain: The Moderating Role of Sense of Community.

The discrimination migrants perceive during their adaptation process is one of the main sources of stress and it affects their well-being, health and integration severely. The present study analyses how the sense of community (SOC) can have a protective effect against the perception of discrimination and its negative consequences by verifying the following theoretical model: discrimination predicts three indicators of psychosocial well-being (psychological distress, satisfaction with life and feelings of social exclusion). Furthermore, the theoretical model proposed also considers the hypothesis that SOC has a moderating role on the effect of perceived discrimination regarding the three variables mentioned above. 1714 migrants from Eastern Europe, Africa and Latin America who live in Málaga, Spain, participated in the study. Data were collected using random-route sampling and survey methodology. After carrying out multiple regression analyses, using the PROCESS tool in SPSS 20, the theoretical model was verified: SOC reduces the negative effects of perceived discrimination for the variables psychological distress, satisfaction with life and social exclusion feelings. Therefore, migrants who have a greater SOC experience fewer negative consequences, as compared to those with a lower SOC, for whom the consequences of such variables are more negative. These results highlight the importance for migrants to rebuild social networks in the host country and develop a good SOC. Results also allow the development of intervention patterns to favor positive interactions between native population and migrants.

Endomycobiome associated with females of the planthopper Delphacodes kuscheli (Hemiptera: Delphacidae): A metabarcoding approach.

A metabarcoding approach was performed aimed at identifying fungi associated with Delphacodes kuscheli (Hemiptera: Delphacidae), the main vector of "Mal de Río Cuarto" disease in Argentina. A total of 91 fungal genera were found, and among them, 24 were previously identified for Delphacidae. The detection of fungi that are frequently associated with the phylloplane or are endophytes, as well as their presence in digestive tracts of other insects, suggest that feeding might be an important mechanism of their horizontal transfer in planthoppers. This study draws the baseline for future research regarding mutualistic associations present in D. kuscheli as well as their physiological role in the life cycle of this important pest that might lead to developing new management strategies to keep insects populations under control.

The endosphere bacteriome of diseased and healthy tomato plants.

Here we analyze the microbial community of healthy and diseased tomato plants to evaluate its impact on plant health. The organisms found in all samples mainly belonged to 4 phyla: Actinobacteria, Bacteroidetes, Firmicutes and Proteobacteria. The Proteobacteria were the highest relative abundant within the endophytic communities of different plant organs of diseased tomato. Among endophytic bacteria of tomato, only a few taxa could be cultured. Here we showed that only a few taxa of bacteria inhabiting tomato plants could be cultured and that all plant organs have a highly diverse endophytic bacterial, whose activity might affect plant growth and development as well as health. The roots seem to be an important barrier for microbes and leaves appear to be the organs with the higher diversity which is incidentally related to plant health. Fruits also contain a complex bacterial community that appeared to be unaffected by foliar diseases such as gray leaf spot at least under the conditions studied.