Assuntos
Recém-Nascido , Preparações Farmacêuticas/metabolismo , Envelhecimento , Anestésicos Locais/metabolismo , Antibacterianos/metabolismo , Anticonvulsivantes/metabolismo , Fármacos Cardiovasculares/metabolismo , Doença/metabolismo , Tratamento Farmacológico , Humanos , Lactente , Recém-Nascido Prematuro , Cinética , Entorpecentes/metabolismo , Salicilatos/metabolismoAssuntos
Anticonvulsivantes/metabolismo , Adulto , Envelhecimento , Carbamazepina/metabolismo , Clonazepam/metabolismo , Diazepam/metabolismo , Doença/metabolismo , Etossuximida/metabolismo , Feminino , Humanos , Cinética , Fenobarbital/metabolismo , Fenitoína/metabolismo , Gravidez , Primidona/metabolismo , Saliva/análise , Ácido Valproico/metabolismoRESUMO
1. Plasma adrenaline and noradrenaline were measured in supine and upright positions in 27 essential hypertensive patients and in 12 age-matched control subjects. 2. Plasma adrenaline was markedly increased in a large proportion of patients, compared with control subjects, either in supine or in upright positions, whereas no significant differences were found in plasma noradrenaline. 3. Six hypertensive patients were chronically treated with beta-adrenoreceptor-blocking agents (five with propranolol and one with pindolol). Plasma noradrenaline was not significantly changed in the supine position but was markedly increased on standing in four out of six patients. Plasma adrenaline was decreased in five out of six patients either in suprine or upright positions. 4. These findings support the view that the adrenergic system participates in the mechanism of essential hypertension.
Assuntos
Epinefrina/sangue , Hipertensão/sangue , Norepinefrina/sangue , Adolescente , Antagonistas Adrenérgicos beta/uso terapêutico , Adulto , Envelhecimento , Feminino , Humanos , Hipertensão/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Postura , Renina/sangueRESUMO
Plasma adrenaline, noradrenaline, and dopamine concentrations and plasma renin activity were measured in the supine position and after standing for 10 minutes in 14 patients with sustained benign essential hypertension and in five patients with labile hypertension. Results were compared with values obtained in 11 normotensive control subjects. In controls plasma noradrenaline concentrations increased with age, while plasma adrenaline values tended to decrease with age. No significant difference in mean plasma noradrenaline was found between hypertensive and control subjects, but plasma noradrenaline seemed slightly increased in a proportion of hypertensive patients aged less than 50. Plasma adrenaline was considerably raised in both supine and standing positions in eight patients with sustained hypertension and in two with labile hypertension. Dopamine concentrations and plasma renin activity were similar in all groups studied. The finding of significantly raised plasma adrenaline concentrations in a large proportion of hypertensive patients supports the hypothesis that the activity of the sympathetic nervous system is increased in essential hypertension. Measurement of plasma adrenaline seems to be a more sensitive index of this activity than that of plasma noradrenaline.
