RESUMO
We report a 73 years old man with a diagnosis of Paget Disease (PD) and symptomatic Multiple Myeloma (MM). Coexistence of MM and PD has rarely been described. PD mimics many of the features of bone destructive process in MM, making differential diagnosis more complicated. In addition, the presence of serious muscolo-skeletal and metabolic complications in both diseases makes management of patients difficult, worsening the prognosis.The comparison of these two diseases has led to the characterization of a common molecular mechanism represented by the receptor activator of nuclear factor-kB ligand (RANKL)/Osteoprotegerin signaling pathway. The improved comprehension of these mechanisms led to the development of new pharmacologic agents (bisphosphonates, cytokines inhibitors) effective for the treatment of these bone diseases.
RESUMO
Herein, we report the case of a 52-year-old man with a spermatic cord liposarcoma that developed 4 years after renal transplantation. The patient was admitted with a diagnosis of inguinal hernia. During surgical exploration, a solid mass was found arising from the spermatic cord. Histologic analysis demonstrated a well-differentiated sclerosing liposarcoma.
Assuntos
Neoplasias dos Genitais Masculinos/cirurgia , Transplante de Rim/fisiologia , Lipossarcoma/cirurgia , Doenças Renais Policísticas/cirurgia , Cordão Espermático/patologia , Cordão Espermático/cirurgia , Neoplasias dos Genitais Masculinos/patologia , Hérnia Inguinal/patologia , Hérnia Inguinal/cirurgia , Humanos , Transplante de Rim/patologia , Masculino , Pessoa de Meia-Idade , Doenças Renais Policísticas/patologia , Resultado do TratamentoRESUMO
A rare case of cystic angiomatoid fibrous histiocytoma of the thigh in a 13-years-old girl is reported. Final diagnosis was made only after surgical excision. A review of the literature with a discussion of the particularity of this case are also examined in order to achieve the best surgical strategy and the lower risk of recurrence.
Assuntos
Cistos/patologia , Histiocitoma Fibroso Maligno/patologia , Adolescente , Cistos/diagnóstico , Diagnóstico Diferencial , Feminino , Histiocitoma Fibroso Maligno/diagnóstico , HumanosAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Ácidos Borônicos/farmacologia , Mieloma Múltiplo/tratamento farmacológico , Plasmócitos/efeitos dos fármacos , Pirazinas/farmacologia , Pele/patologia , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Ácidos Borônicos/administração & dosagem , Ácidos Borônicos/efeitos adversos , Bortezomib , Dexametasona/uso terapêutico , Feminino , Humanos , Imunoglobulina A/sangue , Melfalan/administração & dosagem , Mieloma Múltiplo/patologia , Proteínas do Mieloma/análise , Parestesia/induzido quimicamente , Doenças do Sistema Nervoso Periférico/induzido quimicamente , Plasmócitos/patologia , Prednisona/administração & dosagem , Pirazinas/administração & dosagem , Pirazinas/efeitos adversos , Indução de Remissão , Talidomida/administração & dosagem , Talidomida/efeitos adversos , Xeroftalmia/induzido quimicamenteRESUMO
A 41 year old man with a history of politrauma presented with a nodular mass of the left false vocal cord, associated with progressive dysphonia, dyspnoea, and dysphagia. A computed tomography scan of the neck region showed a rounded and circumscribed mass without infiltration of the surrounding tissues. Histological investigation of the nodule revealed the presence of fibroelastic cartilaginous tissue, surrounded by a thin rim of fibrous tissue, with rare hypercellular areas, occasional binucleated cells, slight hyperchromasia, and an irregular nuclear profile. Mitotic activity was absent. The patient's history of laryngeal trauma, with the subsequent progressive onset of clinical symptoms, helps to distinguish the chondrometaplastic nature of this nodule from true laryngeal cartilaginous tumours, such as chondroma and low grade chondrosarcoma.
