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1.
Injury ; 49 Suppl 3: S19-S25, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30415664

RESUMO

INTRODUCTION: Few clinical studies have analyzed the utility of distal interlocking screws in stable and unstable intertrochanteric fractures treated with intramedullary devices. We performed a prospective analysis comparing short unlocked versus short dynamic and short static distal locked intramedullary nails. MATERIALS AND METHODS: Nine level-II trauma centres were involved in the study. 240 patients over the age of 65 with a stable (AO/OTA 31-A1) or unstable intertrochanteric fracture (AO/OTA 31-A2) were prospectively investigated. The same type of nail was used in every patient. Patients were randomly divided into 3 groups according to the type of distal locking used. Intra-operative variables were examined and patients were followed clinically and radiographically at 1, 3, 6, 12 months postoperatively. All complications were recorded. RESULTS: A total of 212 patients completed 1 year of follow-up visits. In the Unlocking Group (UG) the operation time, blood loss, fluoroscopy time, total length of incision were significantly decreased compared to both the Dynamic Group (DG) and the Static Group (SG) (p < 0.05). Conversely, no reliable differences in intraoperative variables were noted between the Dynamic Group and the Static Group (p > 0.05). In terms of time of fracture union we found no differences among the three Groups (p > 0.05). Moreover, no cases of limb shortening >1 cm or varus collapse were detected in any group. The 3 Groups were similar in terms of HHS, SF-12 and Barthel index results at 1-year follow-up (p > 0.05). Finally, no significant differences were demonstrated across the three Groups in terms of major complications. CONCLUSIONS: This clinical study further confirms the hypothesis that short intramedullary nails do not need to be locked for stable and unstable intertrochanteric fractures.


Assuntos
Pinos Ortopédicos , Fixação Intramedular de Fraturas , Consolidação da Fratura/fisiologia , Fraturas do Quadril/cirurgia , Instabilidade Articular/cirurgia , Idoso , Feminino , Fluoroscopia , Seguimentos , Fixação Intramedular de Fraturas/instrumentação , Fixação Intramedular de Fraturas/métodos , Fraturas do Quadril/diagnóstico por imagem , Fraturas do Quadril/fisiopatologia , Humanos , Instabilidade Articular/diagnóstico por imagem , Instabilidade Articular/fisiopatologia , Masculino , Estudos Prospectivos , Amplitude de Movimento Articular , Centros de Traumatologia , Resultado do Tratamento
2.
Injury ; 47 Suppl 4: S98-S106, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27523625

RESUMO

We investigated whether a proximal femoral nail can be implanted without a distal locking screw in AO/OTA 31-A1 and 31-A2 pertrochanteric stable femur fractures. A multicentre, randomised study was conducted in six level-two trauma centres in our area (Puglia, Italy). A total of 333 patients received their allocated intervention (162 in the locking group [LG] and 171 in the unlocking group [UG]) and 266 patients were included in the final analysis at 1year. Our data showed no statistically significant difference between the two groups at 1-year follow-up for ability to walk, SF-36 questionnaire results, residual pain (visual analogue scale [VAS] score) and level of overall satisfaction. There were also no statistically significant differences between groups for mortality and length of hospital stay. Conversely, the UG was associated with shorter operation and fluoroscopy times, shorter surgical incision length, and less blood loss and residual thigh pain. Pertrochanteric stable fractures (31-A1, 31-A2) can be treated successfully with intramedullary nails without distal locking, reducing patient and clinical personnel radiation exposure and sanitary costs (surgery time and screws costs).


Assuntos
Pinos Ortopédicos , Fraturas do Fêmur/cirurgia , Fixação Intramedular de Fraturas , Fraturas por Osteoporose/cirurgia , Complicações Pós-Operatórias/diagnóstico por imagem , Centros de Traumatologia , Idoso , Idoso de 80 Anos ou mais , Parafusos Ósseos , Feminino , Fraturas do Fêmur/diagnóstico por imagem , Fraturas do Fêmur/fisiopatologia , Fluoroscopia , Fixação Intramedular de Fraturas/métodos , Consolidação da Fratura , Humanos , Itália/epidemiologia , Masculino , Duração da Cirurgia , Fraturas por Osteoporose/diagnóstico por imagem , Fraturas por Osteoporose/fisiopatologia , Satisfação do Paciente , Complicações Pós-Operatórias/fisiopatologia , Complicações Pós-Operatórias/cirurgia , Estudos Prospectivos , Resultado do Tratamento
3.
Int J Gynaecol Obstet ; 30(4): 313-6, 1989 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-2576538

RESUMO

The concentration of prolactin in the amniotic fluid (AFPRL) was measured in 75 samples obtained in the third trimester of 14 isoimmunized women. There was a uniform decline in prolactin levels with advancing gestation in each pregnancy (r = -0.89 to -0.99). The decline in AFPRL was similar in uncomplicated pregnancies. AFPRL levels were not predictive of umbilical cord hemoglobin or bilirubin levels and amniotic fluid lecithin/sphingomyelin ratio.


Assuntos
Líquido Amniótico/análise , Complicações na Gravidez/metabolismo , Prolactina/análise , Isoimunização Rh/metabolismo , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Fosfatidilcolinas/análise , Gravidez , Resultado da Gravidez , Terceiro Trimestre da Gravidez , Estudos Prospectivos , Síndrome do Desconforto Respiratório do Recém-Nascido/metabolismo , Isoimunização Rh/complicações , Esfingomielinas/análise
4.
Pediatrics ; 63(2): 213-8, 1979 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-440810

RESUMO

The fluorescence polarization of 116 amniotic fluid specimens obtained from 22 isoimmunized pregnant women was determined. The degree of fluorescence polarization of amniotic fluid provides an index of microvisocity in lipid aggregates that is dependent on the lecithin-to-sphingomyelin ratio and the degree of saturation of fatty acid side chains. We confirmed the reproducibility of the measurement of amniotic fluid microviscosity (coefficient of variation, 2.0%). The measurements are not effected by bilirubin concentration of amniotic fluid dilution. The pattern of change of amniotic fluid microviscosity during gestation parallels the expected development of the surfactant system. Amniotic fluid microviscosity is high during early gestation and abruptly and sequentially decreases between the 28th and 36th week of gestation. Since the measurements are an accurate reflection of the biochemical properties of amniotic fluid lipids and parallel the development of the surfactant system, we conclude that amniotic fluid microviscosity may well serve as an indicator of the process of fetal lung maturation.


Assuntos
Líquido Amniótico/análise , Polarização de Fluorescência/métodos , Idade Gestacional , Bilirrubina/análise , Eritroblastose Fetal/diagnóstico , Feminino , Humanos , Gravidez , Viscosidade
5.
Hosp Pract ; 13(6): 61-9, 1978 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-99361

RESUMO

Hemolytic disease of newborns is now a preventable disease, 10 years after the introduction of routine postpartum administration of hyperimmune globulin to Rh-negative mothers. Careful adherence to clinical and administrative guidelines, such as those described in this article, can help ensure that every susceptible woman is treated, so that the disease can be eliminated in another decade.


Assuntos
Eritroblastose Fetal/prevenção & controle , Imunoglobulinas/administração & dosagem , Complicações Hematológicas na Gravidez , Sistema do Grupo Sanguíneo Rh-Hr , Canadá , Feminino , Humanos , Recém-Nascido , Masculino , Troca Materno-Fetal , Programas Nacionais de Saúde/economia , Gravidez , Risco
6.
Am J Obstet Gynecol ; 130(7): 782-7, 1978 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-637101

RESUMO

The degree of fluorescence polarization (P value) of 1,6-diphenyl-1,3,5-hexatriene has been shown to be an excellent indicator of the lecithin/sphingomyelin (L/S) ratio in laboratory prepared liposomal dispersions. In order to test the validity of this technique in amniotic fluid, the L/S ratio and P value of 161 amniotic fluid specimens were determined. In 127 the P value was less than or equal to 0.336 and the L/S ratio was greater than or equal to 2. In 26 the P value was greater than 0.336 and the L/S ratio was less than 2 (P less than 0.05). The amniotic fluid P value is affected by blood or meconium but not by surgical lubricants or bilirubin. We concluded that the degree of fluorescence polarization of amniotic fluid indicates fetal lung maturity as reliably as the L/S ratio. However, this method has important technical and practical advantages that make it more applicable for a clinical laboratory.


Assuntos
Líquido Amniótico , Pulmão/embriologia , Líquido Amniótico/análise , Sangue , Feminino , Hemólise , Humanos , Lipossomos/análise , Lubrificação , Mecônio , Fosfatidilcolinas/análise , Polienos , Gravidez , Espectrometria de Fluorescência , Esfingomielinas/análise , Viscosidade
8.
N Engl J Med ; 292(19): 1014-6, 1975 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-804134

RESUMO

PIP: 10 years' clinical experience with Rh immune globulin in the prevention of Rh hemolytic disease is reported. The data show a steady decline in the actual numbers of sensitized mothers and affected babies for each successive year after the initiation of treatment with Rh immune globulin. It is concluded that all Rh-negative women who are at any risk of becoming sensitized to Rh must be protected with Rh immune globulin irrespective of whether they have had a term pregnancy (Rh-positive infant), an abortion or an accidental transfusion with Rh-positive blood.^ieng


Assuntos
Eritroblastose Fetal/prevenção & controle , Imunoglobulinas/uso terapêutico , Sistema do Grupo Sanguíneo Rh-Hr , Formação de Anticorpos , Eritroblastose Fetal/epidemiologia , Estudos de Avaliação como Assunto , Feminino , Humanos , Imunoglobulinas/administração & dosagem , Recém-Nascido , Isoanticorpos , Masculino , Cidade de Nova Iorque , Gravidez , Fatores de Tempo
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