Connective tissue disease associated with sclerodermoid features, early abortion, and circulating anticoagulant.

An 18-year-old white woman admitted for an incomplete septic abortion was found to have thrombocytopenia, anemia, and increased activated partial thromboplastin time (PTT). Additionally, results of nontreponemal serologic tests for syphilis were positive, and the fluorescent antinuclear antibody was weakly positive. A mixture of the patient's plasma with normal control plasma showed that the elevation in activated PTT was the result of a circulating anticoagulant, not an inherent clotting defect. Sclerodermoid features were present and consisted of bound-down, hairless skin and scattered subcutaneous indurated plaques. A faint pattern consistent with livedo reticularis was recognized on all extremities. Biopsy specimens of sclerodermoid lesions showed increased and thickened dermal collagen consistent with morphea. We believe that this patient's condition represents an unusual connective tissue disease syndrome consisting of abortion, livedo reticularis, thrombocytopenia, circulating "anticoagulant," negative or slightly positive antinuclear antibodies, and false positive results on nontreponemal serologic tests for syphilis. Sclerodermoid lesions were also a unique feature in our patient.

Use of gloves among dermatologists.

Despite evidence that rubber or latex surgeon's gloves appear to prevent or reduce the transmission of hepatitis B virus, physicians continue to perform surgical procedures without wearing gloves. Surveys regarding glove usage among members of the American Academy of Dermatology revealed that a majority of those responding do not regularly wear gloves while performing basic dermatologic procedures, such as shave and punch biopsies and curettage and desiccation. Others are still not wearing gloves regularly while performing excisional surgery, hair transplants, and dermabrasion procedures.