[Action of antihistaminic agents in patients with various heart pathologies undergoing surgical treatment]. / Issledovanie deistviia protivogistaminnykh sredstv u bol'nykh s razlichnoi patologiei serdtsa pri khirurgicheskom lechenii.

Clinical observations and experimental studies enabled the authors to show that sensitivity of patients with rheumatic heart diseases to antihistaminic drugs is not always constant. It depends on pH value of the medium and blood concentration of calcium ions. It is advisable to include antihistaminic drugs in combination with colloid and crystalloid blood substitutes with regard to pH of the medium into the complex of agents for pre-, intra- and postoperative medication.

[Clinical study of the pharmacodynamics of drugs used for premedication]. / Klinicheskoe izuchenie farmakodinamiki lekarstvennykh veshchestv, primeniaemykh dlia premedikatsii.

The use of premedication varieties in surgical treatment of 52 patients with heart diseases of varying etiology has demonstrated that the most effective were antihypoxic agents (sodium hydroxybutyrate), substances reducing myocardial requirement of oxygen (cardiac glycosides) and decreasing load of the heart (anapriline, verapamil), normalizing myocardial function (a polarizing mixture, cardiac glycosides), antithrombotic substances (heparin), antihistamine and antishock agents (diphenhydramine, pipolphen, morphine, promedol, prednisolone, neuroleptics, tranquilizers), and substances that enhance the neutralizing liver function (vitamins B and C). Drug correction of the functional and biochemical indicators should be strictly individualized with regard to the patient's age, type of pathology, and the scope of the coming surgical intervention.