Anxiety and Depression as Longitudinal Predictors of Mild Cognitive Impairment in Older Adults.

INTRODUCTION: Few studies have dealt with the potential correlation between anxiety, depression, and cognitive impairment in community-dwelling older adults. METHOD: This longitudinal study was conducted in the city of Montreal, Canada, with 352 older adults aged 55 years or more. The participants were interviewed at baseline and again 2 years later. The Montreal Cognitive Assessment (MoCA) score was estimated and compared between the 2 time points, the Composite International Diagnostic Interview (CIDI) was used to assess major depression and anxiety, and the K10 measured high psychological distress. Likewise, major depression, anxiety disorders, and psychological distress were evaluated at the 2 study time points. RESULTS: In older adults with a diagnosis of depression or anxiety at baseline, no significant reduction in the MoCA score indicating deterioration in cognitive function was found 2 years later. Nevertheless, in individuals with a high level of psychological distress at baseline, there was a significant reduction in MoCA scores 2 years later, indicating deterioration in cognition. The findings of the present study suggest that a high level of psychological distress in addition to environmental factors may constitute important predictors for cognitive health.

Increased Anxiety, Akathisia, and Suicidal Thoughts in Patients with Mood Disorder on Aripiprazole and Lamotrigine.

Introduction. Akathisia affects around 18% of patients with bipolar disorder treated with aripiprazole and may worsen when aripiprazole is combined with lamotrigine and antidepressants. Case. This paper reports on two clinical cases involving patients with a diagnosis of mood disorder who developed severe akathisia, anxiety, and suicidal ideation while using a combination of aripiprazole, antidepressants, and lamotrigine. Discussion. We recommend that patients with a mood disorder taking multiple drugs should begin aripiprazole therapy with low doses and be monitored for the development of akathisia, increased anxiety, or suicidal thoughts. The appearance of these limiting side effects requires discontinuation of the drug.

Control of psychomotor agitation and aggressive behavior in patients with autistic disorder: a retrospective chart review.

OBJECTIVE: To evaluate the efficacy of pharmacotherapy on the symptoms of psychomotor agitation and aggressive behavior in a sample of patients with autistic spectrum disorder. METHOD: The charts of all patients with a diagnosis of autistic spectrum disorder, receiving care for psychomotor agitation and/or aggressive behavior in two psychiatric outpatient departments between 2001 and 2006, were reviewed. The Clinical Global Impression-Severity and -Improvement scales (CGI-S and CGI-I) were applied to the data retrieved from the charts. RESULTS: The majority of the 26 patients included were treated with second-generation antipsychotics. A positive, statistically significant correlation was found between the implementation of pharmacotherapy and a reduction in CGI-S scores (p<0.05). Treatment response in patients with no mental retardation was better than in those mentally retarded (p<0.05). The majority of patients in whom clinical improvement was found following implementation of treatment had participated in at least one form of intervention therapy in addition to the principal treatment (p<0.05). CONCLUSION: Second-generation antipsychotics seem to reduce psychomotor agitation and aggressive behavior in patients with autistic spectrum disorder; however, further studies are required to evaluate the side effects of these drugs in relation to their beneficial effects.

Control of psychomotor agitation and aggressive behavior in patients with autistic disorder: a retrospective chart review / Controle da agitação psicomotora e agressividade em pacientes com autismo: estudo retrospectivo de revisão de prontuário

OBJECTIVE: To evaluate the efficacy of pharmacotherapy on the symptoms of psychomotor agitation and aggressive behavior in a sample of patients with autistic spectrum disorder. METHOD: The charts of all patients with a diagnosis of autistic spectrum disorder, receiving care for psychomotor agitation and/or aggressive behavior in two psychiatric outpatient departments between 2001 and 2006, were reviewed. The Clinical Global Impression-Severity and -Improvement scales (CGI-S and CGI-I) were applied to the data retrieved from the charts. RESULTS: The majority of the 26 patients included were treated with second-generation antipsychotics. A positive, statistically significant correlation was found between the implementation of pharmacotherapy and a reduction in CGI-S scores (p<0.05). Treatment response in patients with no mental retardation was better than in those mentally retarded (p<0.05). The majority of patients in whom clinical improvement was found following implementation of treatment had participated in at least one form of intervention therapy in addition to the principal treatment (p<0.05). CONCLUSION: Second-generation antipsychotics seem to reduce psychomotor agitation and aggressive behavior in patients with autistic spectrum disorder; however, further studies are required to evaluate the side effects of these drugs in relation to their beneficial effects.

OBJETIVO: Avaliar a eficácia do tratamento farmacológico dos sintomas de agitação psicomotora e agressividade em amostra de pacientes com transtorno do espectro autista. MÉTODO: Foram revisados os prontuários de pacientes com diagnóstico de transtorno do espectro autista que procuraram atendimento por apresentarem agitação psicomotora e/ou heteroagressividade, atendidos entre 2001 e 2006, em dois ambulatórios de psiquiatria. Para avaliação da evolução dos pacientes aplicou-se às informações do prontuário a escala de Impressão Clínica Global Sintomas (ICG-S) e a Impressão Clínica Global Melhora (ICG-M). RESULTADOS: A maioria dos 26 pacientes estava em tratamento com antipsicóticos de segunda geração. Houve correlação positiva e estatisticamente significativa entre a introdução do tratamento farmacológico e a redução nos escores da ICG-S (p<0,05). A evolução do tratamento farmacológico foi melhor para os pacientes sem retardo mental do que para aqueles com retardo mental (p<0,05). A maioria dos pacientes que obteve melhora clínica com o tratamento participava de ao menos uma intervenção auxiliar ao tratamento principal (p<0,05). CONCLUSÃO: Os antipsicóticos de segunda geração parecem reduzir a agitação psicomotora e agressividade em pacientes com transtorno do espectro autista no Brasil. É necessário que se avaliem os efeitos colaterais em relação aos efeitos benéficos dessas drogas.

Prevalence of attention deficit hyperactivity disorder in schoolchildren in the city of Salvador, Bahia, Brazil.

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is the most common neuropsychiatric disorder of infancy and one of the most prevalent chronic diseases found in schoolchildren. OBJECTIVE: To evaluate the prevalence of ADHD in schoolchildren through the use of a questionnaire responded by school-teachers. METHOD: A total of 774 children enrolled in the public and private school systems were evaluated. The diagnostic instrument used was a Teacher ADHD scale. RESULTS: Results showed that 6.7% of children were considered highly likely to have the disorder. Of the more severe cases of ADHD, the hyperactive-impulsive subtype was more frequently identified in girls, while the inattentive subtype was more prevalent among boys. CONCLUSION: The symptoms of attention deficit in hyperactive children may be underestimated by teachers since the symptoms of hyperactivity are more noticeable and disruptive.

Prevalence of attention deficit hyperactivity disorder in schoolchildren in the city of Salvador, Bahia, Brazil

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is the most common neuropsychiatric disorder of infancy and one of the most prevalent chronic diseases found in schoolchildren. OBJECTIVE: To evaluate the prevalence of ADHD in schoolchildren through the use of a questionnaire responded by school-teachers. METHOD: A total of 774 children enrolled in the public and private school systems were evaluated. The diagnostic instrument used was a Teacher ADHD scale. RESULTS: Results showed that 6.7 percent of children were considered highly likely to have the disorder. Of the more severe cases of ADHD, the hyperactive-impulsive subtype was more frequently identified in girls, while the inattentive subtype was more prevalent among boys. CONCLUSION: The symptoms of attention deficit in hyperactive children may be underestimated by teachers since the symptoms of hyperactivity are more noticeable and disruptive.

INTRODUÇÃO: O transtorno de déficit de atenção e hiperatividade (TDAH) é o distúrbio neuropsiquiátrico mais comum na infância, estando, também, entre as doenças crônicas mais prevalentes em crianças escolares. OBJETIVO: Estimar a prevalência do TDAH em escolares através de inquérito com professores. MÉTODO: Foram avaliadas 774 crianças, matriculados na rede pública e privada de ensino. O instrumento diagnóstico utilizado foi a Escala de TDAH versão para professores. RESULTADOS: Estimou-se que 6,7 por cento das crianças apresentavam alta probabilidade de apresentar o distúrbio. Dentre os casos mais severos de TDAH o subtipo hiperativo-impulsivo foi mais prevalente nos escolares do sexo feminino, enquanto o subtipo desatento foi mais prevalente entre as crianças do sexo masculino. CONCLUSÃO: Os sintomas do déficit de atenção em crianças hiperativas podem ser subestimados pelos professores visto que os sintomas da hiperatividade são mais disruptivos e visíveis.

[A pilot study of prevalence of hyperactivity and attention deficit disorder in scholar children in Salvador, Bahia, Brazil]. / Estudo piloto da prevalência do transtorno de déficit de atenção e hiperatividade entre crianças escolares na cidade do Salvador, Bahia, Brasil.

This study aims to estimate the prevalence of attention deficit hyperactivity disorder (ADHD) in scholar children through a teacher's questionnaire. A pilot study was conducted based in the total number of students under high school, in public and private schools in Salvador, Bahia, Brazil. The instrument used was Teacher's version of ADHS scale. Eight kids (5.3%) were recognized as highly probability of attention deficit disorder, three (2%) with high probability of subtype hyperactive/impulsive, and one (0.6%) as combined subtype. Children with ADHD might have serious social problems, not only brought by the disorder, but also due to co morbidity with other disorders, leading to serious social withdrawn. Early diagnostic and treatment of ADHD might improve educational and psychosocial development of these kids.

Estudo piloto da prevalência do transtorno de déficit de atenção e hiperatividade entre crianças escolares na cidade do Salvador, Bahia, Brasil / A pilot study of prevalence of hyperactivity and attention deficit disorder in scholar children in Salvador, Bahia, Brazil

O presente estudo se propõe a estimar a prevalência do transtorno de déficit de atenção e hiperatividade (TDAH) em escolares através de inquérito com professores. Foi realizado um estudo piloto baseado no total de alunos do ensino fundamental, em escolas da rede pública e privada da cidade do Salvador, BA. O instrumento diagnóstico utilizado foi a Escala de TDAH versão para professores. Oito crianças (5,3 por cento) apresentavam alta probabilidade de ter o subtipo predominantemente desatento, três escolares (2 por cento) apresentavam alta probabilidade de apresentar o subtipo predominantemente hiperativo/impulsivo e uma criança (0,6 por cento) apresentava alta probabilidade de apresentar o subtipo combinado. Crianças com TDAH podem ter sérios problemas de funcionamento social. O problema não se resume aos déficits trazidos pela doença, mas à associação co-mórbida com outros transtornos, que pode resultar em comprometimento social grave. O reconhecimento precoce e o manejo adequado do TDAH pode redirecionar o desenvolvimento educacional e psicossocial dessas crianças.