The DBH -1021 C/T polymorphism is not associated with alcoholism but possibly with patients' exposure to life events.

Two DBH polymorphisms were investigated in 114 Brazilian alcoholics of European descent and 233 controls. Personality and life events were also analyzed among alcoholics. No significant differences were observed in allele or genotype frequencies between alcoholics and controls. No association was detected between the polymorphisms and personality dimensions. Carriers of the -1021 T allele presented a higher number (F = 7.49; P = 0.007) of life events. This study provides a preliminary indication that the DBH -1021 C/T polymorphism influences the exposure to life events.