18F-DCFPyL PET/CT guidelines.

The objective of this guide is to provide to nuclear medicine physicians a tool based on scientific evidence and prepared by consensus of experts, to perform the 18F-DCFPyL PET/CT procedure with safely and efficiently for patients with prostate cancer who present PSMA overexpression. For them, some recommendations will be established for 18F-DCFPyL PET/CT examination: reconstruction parameters, presentation of the images and their interpretation. The possible false positives of the procedure will be analysed, how to interpret them and how to avoid them. Finally, all exploration should lead to the preparation of a report that answers the clinician's question. For this, it is recommended to prepare a structured report that includes the PROMISE criteria as well as the classification of the findings according to PSMA-RADS parameters.

Veinticinco años de la Revista Española de Medicina Nuclear. Estudio bibliométrico / Twenty-five years of the spanish journal of nuclear medicine. Bibliometric study

Objetivo. Analizar el contenido científico de la Revista Española de Medicina Nuclear (REMN) tras 25 años de publicación. Material y métodos. De 1.181 artículos publicados se ha extraído: nombre y apellidos del primer autor, hospital y Comunidad Autónoma, año de publicación, tema del estudio y sección de la revista. Se han obtenido los siguientes datos: número de publicaciones y originales por autor, hospital, Comunidad Autónoma y país de origen, globalmente y por lustro. Para la introducción y análisis de los datos se han usado los programas Access y Excel. Resultados. Los artículos originales constituyen el 40% (473/1.181) de las publicaciones, siendo la sección Originalesla de mayor contenido desde el inicio salvo en el período1987-1991, donde se publicaron mayoritariamente colaboraciones especiales. Los temas más frecuentemente tratados fueron Oncología (11,4 %), Cardiología (10,7 %), Osteoarticular (9,8 %) y Radioinmunoanálisis (8,9 %). Los temas oncológicos han ocupado el interés de la mayoría de las publicaciones en la última década, destacando en los últimos 5 años los estudios con tecnología de tomografía por emisión de positrones.Se han publicado 146 manuscritos procedentes de 24 paísesextranjeros, principalmente de habla hispana, y preferentemente artículos originales (83/146).Con relación a los artículos españoles observamos que lasComunidades de Madrid y Cataluña son las más productivas(47 %) desde el inicio de la REMN, siendo los Hospitales Lozano Blesa de Zaragoza, Bellvitge y Clinic de Barcelona los centros con más artículos publicados.Conclusiones. Tras 25 años la REMN se ha consolidadocomo revista científica de referencia en el área de la Medicina Nuclear, especialmente en lengua española. La inclusión en Medline/Index Medicus supuso un incremento en los manuscritos originales publicados

Objective. To analyze the scientific content of the Revista Española de Medicina Nuclear (REMN) after twenty-five years of publication. Material and methods. From 1.181 published articles it has been extracted: name and surnames of the first author, Hospital and Autonomous Region, year of publication, topic of the study and section of the journal. The following information has been obtained: n.º of publications and original articles for author, Hospital, Autonomous Community and Country, globally and per period. For the introduction and analysis of the information the programs Access and Excel have been used. Results. The original articles constitute 40 % (473/1181) of the publications being the section Original that of major content from the beginning except in the period 1987-91 where SpecialCollaborations were published for the most part.The topics more frequently treated were oncology (11.4 %), cardiology (10.7 %), osteoarticular (9.8 %) and radioinmunoassays (8.9 %). The oncological topics have occupied the interest of the majority of the publications in the last decade, emphasizing in the last five years the studies with technology PET. Have been published 146 manuscripts proceeding from 24 foreign, principally Spanish-speaking countries and preferablyoriginal articles (83/146). With relation to the Spanish articles we observe that the regions of Madrid and Cataluña are the most productive (47 %) from the beginning of the REMN being the Hospitals LozanoBlesa of Zaragoza, Bellvitge and Clinic of Barcelona the centers with more published articles. Conclusions. After twenty-five years, the REMN has been consolidated as scientific journal of reference in the Nuclear Medicine specially in Spanish language. The incorporation inMedline/Index Medicus supposed an increase in the original published manuscripts

[Twenty-five years of the Spanish Journal of Nuclear Medicine. Bibliometric Study]. / Veinticinco años de la Revista Española de Medicina Nuclear. Estudio bibliométrico.

OBJECTIVE: To analyze the scientific content of the Revista Española de Medicina Nuclear (REMN) after twenty-five years of publication. MATERIAL AND METHODS: From 1.181 published articles it has been extracted: name and surnames of the first author, Hospital and Autonomous Region, year of publication, topic of the study and section of the journal. The following information has been obtained: n. of publications and original articles for author, Hospital, Autonomous Community and Country, globally and per period. For the introduction and analysis of the information the programs Access and Excel have been used. RESULTS: The original articles constitute 40 % (473/1181) of the publications being the section Original that of major content from the beginning except in the period 1987-91 where Special Collaborations were published for the most part. The topics more frequently treated were oncology (11.4 %), cardiology (10.7 %), osteoarticular (9.8 %) and radioinmunoassays (8.9 %). The oncological topics have occupied the interest of the majority of the publications in the last decade, emphasizing in the last five years the studies with technology PET. Have been published 146 manuscripts proceeding from 24 foreign, principally Spanish-speaking countries and preferably original articles (83/146). With relation to the Spanish articles we observe that the regions of Madrid and Cataluña are the most productive (47 %) from the beginning of the REMN being the Hospitals Lozano Blesa of Zaragoza, Bellvitge and Clinic of Barcelona the centers with more published articles. CONCLUSIONS: After twenty-five years, the REMN has been consolidated as scientific journal of reference in the Nuclear Medicine specially in Spanish language. The incorporation in Medline/Index Medicus supposed an increase in the original published manuscripts.

[Analysis of gastric emptying dynamics in relationship to qualitative composition of intake. Comparison between normal-weight and obese subjects]. / Análisis de la dinámica de vaciamiento gástrico en relación con la composición cualitativa de la ingesta. Comparación entre sujetos con normopeso y obesos.

AIMS: To analyze whether the gastric emptying profile could define obesity and to study the impact of macronutrients diet composition on gastric emptying in obese and non obese people. MATERIAL AND METHODS: 47 subjects were selected (12 non obese and 35 obese). The study was organized in 4 visits. In each visit the subject was given isocaloric breakfast differing in macronutrient composition, (either equilibrated, or lipid, protein or carbohydrate rich) quantitative gastric emptying assay was done realized, every 15 minutes for two hours using a radionuclide technique. The week prior to the visit, the subject followed a standard 1,800 cal/day diet. RESULT: A significant interaction between time and diet composition is shown regardless of the group (obese or non-obese) the subject belongs to. The different macronutrient composition differentially affected gastric emptying only in the obese group. Post hoc analysis of the results showed significant differences after 45 min post breakfast between protein and carbohydrate rich breakfast. CONCLUSIONS: Gastric emptying in obese but not in non obese subjects, was significantly modified depending on the intake qualitative composition. These differences are clear when protein rich (significantly slower emptying) is compared versus hydrocarbon enriched diet (significantly faster emptying). A significant difference in gastric emptying between obese and non-obese subjects cannot be established.

Análisis de la dinámica de vaciamiento gástrico en relación con la composición cualitativa de la ingesta. Comparación entre sujetos con normopeso y obesos / Analysis of gastric emptying dynamics in relationship to qualitative composition of intake. Comparison between normal weight and obese subjects

Objetivos. Analizar si el perfil de vaciamiento gástrico podría ser característico en obesidad y estudiar el impacto que la relación de macronutrientes en la dieta tiene sobre el vaciamiento gástrico y las diferencias entre obesos y normopesos. Material y método. Se seleccionan 47 sujetos (12 normopeso y 35 obesos), que realizan 4 visitas durante el estudio. En cada una se administraba un desayuno isocalórico con distinta composición de macronutrientes (equilibrados, lipídico, proteico o hidrocarbonato). Se realizaron estudios cuantitativos de vaciamiento gástrico cada 15 minutos durante dos horas usando la técnica de gammagrafía. La semana previa a cada visita todos los sujetos realizaron una dieta estándar de 1.800 cal/día. Resultados. Se observa una interacción significativa entre los factores tiempo y dieta. Sin embargo, el mismo análisis no demostró esta tendencia al estudiar la evolución del vaciamiento en relación con el grupo al que pertenecía el sujeto (normopeso u obeso). La composición cualitativa de la dieta sólo influyó sobre el vaciamiento gástrico en obesos. El estudio post hoc demostró diferencias significativas fundamentalmente a partir de los 45 minutos postingesta, y entre ingestas ricas en hidratos de carbono y proteínas. Conclusiones. La composición cualitativa de la ingesta ha influido de forma significativa sobre la velocidad de vaciamiento gástrico en sujetos obesos, pero no en normopesos. Esta influencia se hace más evidente en la dieta hidrocarbonada (vaciamiento significativamente más rápido) y proteica (vaciamiento significativamente más lento). No puede establecerse una diferencia significativa de la velocidad de vaciamiento gástrico entre sujetos obesos o normopeso

Aims. To analyze whether the gastric emptying profile could define obesity and to study the impact of macronutrients diet composition on gastric emptying in obese and non obese people. Material and methods. 47 subjects were selected (12 non obese and 35 obese). The study was organized in 4 visits. In each visit the subject was given isocaloric breakfast differing in macronutrient composition, (either equilibrated, or lipid, protein or carbohydrate rich) quantitative gastric emptying assay was done realized, every 15 minutes for two hours using a radionuclide technique. The week prior to the visit, the subject followed a standard 1,800 cal/day diet. Result. A significant interaction between time and diet composition is shown regardless of the group (obese or non obese) the subject belongs to. The different macronutrient composition differentialy affected gastric emptying only in the obese group. Post hoc analysis of the results showed significant differences after 45 min post breakfast between protein and carbohydrate rich breakfast. Conclusions. Gastric emptying in obese but not in non obese subjects, was significantly modified depending on the intake qualitative composition. These differences are clear when protein rich (significantly slower emtying) is compared versus hydrocarbon enriched diet (significantly faster emptying). A significant difference in gastric emptying between obese and non obese subjects cannot be stablished

[Diagnosis using monoclonal antibody imaging in the clinical follow-up of colorectal cancer]. / Diagnóstico por imagen con anticuerpos monoclonales en el seguimiento clínico del cáncer colorrectal.

A total of 44 patients with a range of ages between 34 and 72 were studied by immunoscintigraphy. They have surgical treatment for colon and rectum carcinomas. The immunoradiotracer used was a cocktail of F(ab')2 monoclonal-antibodies anti-CEA and CA 19.9. Planar images were obtained 4th, 6th, and 10th days postinjection. In some cases we used digital subtraction of image. Both CEA and CA 19.9 tumor markers were measured in patients serum. The method shows a global high sensitivity (88%), and specificity (92%).

[Total and specific IgE determination in children allergy. A comparison with the skin tests (author's transl)]. / Determinación de IgE total y específica en la alergia infantil. Correlación con las pruebas dérmicas.

Authors have carried out 478 IgE determinations by radioimmunoassay on children under 14. 78 determinations on healthy children were used to obtain normal IgE values according to age. The remaining determinations referred to 400 children, who came to the Allergy Department. In 120 cases IgE values above 100 U/ml were obtained. In 97 cases a skin test and a specific IgE determination (RAST) carried out compared to 11 allergens. Authors compared the results in order to evaluate the diagnostic reliability of both tests. The RAST specificity was higher than the skin test. The predictive value of the positive RAST was 0.96. Because of its easy accomplishment, innocuity, high specificity and high predictive value, the total and specific IgE determination turns out to be very useful in the diagnosis of children allergy.