RESUMO
PURPOSE: To assess whether unilateral amygdala seizures are associated with a change in the number and lateral distribution of gonadotropin releasing hormone (GnRH)-staining fibers in the ventromedial hypothalamus of female rats. METHODS: The study compared three groups of female rats: (1) amygdala seizures induced by focal injection of kainic acid (KA); (2) saline injected controls; and (3) nai;ve controls. The animals were sacrificed at 4 weeks in the diestrus phase. GnRH fibers were counted in the ventromedial hypothalamus and compared among groups. RESULTS: GnRH fiber counts were significantly lower in KA than saline and nai;ve animals ipsilaterally but not contralaterally. CONCLUSIONS: This finding may support a potential mechanism by which (1) temporolimbic epilepsy may promote the development of reproductive endocrine disorders and (2) the laterality of the epilepsy may influence the particular nature of the reproductive endocrine disorder.
Assuntos
Tonsila do Cerebelo/patologia , Hormônio Liberador de Gonadotropina/metabolismo , Excitação Neurológica/patologia , Convulsões/patologia , Animais , Modelos Animais de Doenças , Feminino , Hipotálamo Médio/metabolismo , Hipotálamo Médio/patologia , Imuno-Histoquímica , Ácido Caínico/toxicidade , Excitação Neurológica/metabolismo , Neurônios/metabolismo , Ratos , Ratos Sprague-Dawley , Convulsões/induzido quimicamente , Convulsões/metabolismoRESUMO
Article abstract-- In an investigation of 100 women with localization-related epilepsy, anovulatory cycles were significantly greater in proportion in women with 21-25 or 33-35 day cycles (Group B) and in women with less than 21 or more than 35 day cycles (Group C) than in women with normal 26-32 day intervals (Group A). Groups B and C also had significantly higher estradiol/progesterone ratios than Group A. Nevertheless, almost one-half (46.2%) of the anovulatory cycles occurred in women with normal 26-32 day cycles.
Assuntos
Epilepsias Parciais/fisiopatologia , Ciclo Menstrual/fisiologia , Ovulação/fisiologia , Adulto , Anovulação/diagnóstico , Anovulação/fisiopatologia , Eletroencefalografia , Epilepsias Parciais/diagnóstico , Estradiol/sangue , Feminino , Humanos , Progesterona/sangue , Valores de ReferênciaRESUMO
A transcranial magnetic stimulation paired-pulse paradigm was used to determine that cortical excitability was less during the late luteal phase than in the early follicular phase in a woman with epilepsy who had premenstrual seizure exacerbation. The data are consistent with the possibility that a reduction in GABA-mediated cortical inhibitory activity may be responsible. The administration of progesterone, a reproductive steroid with potent GABAergic metabolites, during the luteal phase restored cortical excitability to normal range.