The Effects of Prenatal Pravastatin Treatment in the Rabbit Fetal Growth Restriction Model.

Fetal growth restriction (FGR) remains without an effective prenatal treatment. Evidence from murine FGR models suggests a beneficial effect of prenatal pravastatin. Since the rabbit hemodichorial placenta more closely resembles the human condition, we investigated the effects of prenatal maternal pravastatin administration in the rabbit FGR model. At a gestational age of 25 days (term 31d), pregnant dams underwent partial uteroplacental vessel ligation (UPVL) in one uterine horn to induce FGR, leaving the other horn as a control. Dams were randomized to either receive 5 mg/kg/d pravastatin dissolved in their drinking water or normal drinking water until delivery. At GA 30d, the rabbits were delivered and were divided into four groups: control without pravastatin (C/NoPrav), FGR without pravastatin (FGR/NoPrav), FGR with pravastatin (FGR/Prav), and controls with pravastatin (C/Prav). The newborn rabbits underwent pulmonary functional assessment and neurobehavioral assessment, and they were harvested for alveolar morphometry or neuropathology. The placentas underwent histology examination and RNA expression. Birth weight was lower in the FGR groups (FGR/Prav, FGR/NoPrav), but there was no difference between FGR/Prav and C/NoPrav. No differences were noted in placental zone proportions, but eNOS in FGR/Prav placentas and VEGFR-2 in FGR/Prav and C/Prav were upregulated. There were no differences in pulmonary function assessment and alveolar morphometry. FGR/Prav kittens had increased neurosensory scores, but there were no differences in neuromotor tests, neuron density, apoptosis, and astrogliosis. In conclusion, in the rabbit FGR model, pravastatin upregulated the expression of VEGFR-2 and eNOS in FGR placentas and was associated with higher neurosensory scores, without measurable effects on birthweight, pulmonary function and morphology, and neuron density.

Changing attitudes toward redistribution: The role of perceived economic inequality in everyday life and intolerance of inequality.

Modern societies are characterized by economic inequality. Redistributive policies are one of the means to reduce it. We argue that perceived economic inequality in everyday life and intolerance of it are central factors to enhance positive attitudes toward redistribution. To test it, we conducted a four-wave longitudinal panel study in Chile with a sample of 1221 college students (at T1 - baseline, 960 at T2, 926 at T3, and 787 at T4; Mage = 18.89). As expected, a cross-lagged longitudinal analysis controlled by household income confirmed a positive relationship between perceived economic inequality in everyday life and intolerance of inequality, which in turn was positively associated with support for redistributive policies. These results were stable and consistent over time, supporting the idea that perceived economic inequality in everyday life enhances positive attitudes toward redistribution by increasing intolerance of it. Results highlight the important role played by perceived inequality in everyday life.