[Informative value of several clinical, anamnestic, social, hygienic and epidemiologic parameters of immunologic deficiency risk in miners with frequent and long-lasting acute respiratory viral infections]. / Informativnost' nekotorykh kliniko-anamnesticheskikh, sotsial'no-gigienicheskikh i épidemiologicheskikh pokazatelei riska immunologicheskoi nedostatochnosti u chasto i dlitel'no boleiushchikh ostrymi respiratornymi virusnymi infektsiiami shakhterov.

The authors studied poll results and medical documents of miners with frequent and long acute respiratory viral infections and apparently healthy ones in order to reveal clinical, anamnestic, social, hygienic and epidemiologic risk factors for immune deficiency. As a result, the authors identified some signs of immune pathologic conditions (pulmonary diseases, upper respiratory tract disorders, skin lesions) among the miners with frequent and long acute respiratory viral infections. Such factors as presence of children or relatives who are frequently ill, alcohol abuse, smoking and unfavorable living conditions result in weaker immune resistance of the miners with frequent and long acute respiratory viral infections.

Pathogenetic and functional characterization of lymphocytes in influenza patients.

The kinetics of acrocentric chromosome associations and chromosome aberrations in peripheral blood and pleural exudate lymphocytes has been studied in 25 influenza patients and 7 exudative pleurisy patients. Lymphocytes without associations and with 2 associated acrocentric chromosomes were activated in the body, since their frequency appeared to be positively correlated with the immunoresponsiveness indices and with clinical symptoms. The number of these lymphocytes in pleural exudate was 2.5 times higher than in the peripheral blood. When comparing the frequency of chromosome aberrations in the patients' lymphocytes to the level of immunity, cytogenetic changes corresponded to the indices of cellular rather than humoral immunity.

[Methodological and clinical aspects of radionuclide diagnosis of thyroid diseases]. / Metodicheskie i klinicheskie aspekty radionuklidnoi diagnostiki zabolevanii shchitovidnoi zhelezy.

A multimodality radionuclide study including thyroscintigraphy, thyroprofilography, radioimmunoassay to determine the levels of thyroid hormones and TSH in the blood serum, and a new method of radionuclide thyrochronoscopy, was conducted in 32 patients with diffuse and nodular enlargement of the thyroid and in 5 patients of the control group. Thyrochronoscopic results were used to determine the percentage of absorption of 99mTc-pertechnate by the thyroid on the 20th minute, exponential index of absorption and clearance index. Their values turned out elevated in the patients with hyperthyroidism and suspicion for hyperthyroidism. Three degrees of marked compensatory capabilities of the thyroid tissue were singled out in the patients with the euthyroid status. The study showed the diagnostic value of thyrochronoscopic findings in examining thyroid function. In this view the use of cross-sectional scanning proved to be less informative. Not in all the patients did the levels of thyroid hormones and TSH correlate with thyrochronoscopic findings because they make it possible to reveal the disturbance of the compensatory capabilities of the thyroid before the development of hormonal changes. The use of radionuclide thyrochronoscopy enhances the diagnostic efficacy of a comprehensive study of the thyroid.

[Cytogenetic and immunological methods of evaluating the infectious and vaccinal processes in exposure to the mumps virus]. / Otsenka tsitogeneticheskimi i immunologicheskimi metodami infektsionnogo i vaktsinal'nogo protsessov pri vozdeistvii virusa parotita.

Chromosomal changes in T-lymphocytes of the peripheral blood reflect their participation in immune responses. In particular, the level of the associative index of acrocentric chromosomes (AIAC) depends upon their proliferative activity in response to antigens and migration in the host. The degree of cytogenetic and serological changes in patients with mumps was higher than in children of the other groups examined. A relationship was found between the level of AIAC in T-lymphocytes and a rise in the antihemagglutinin titres at the expense of changes in the portion of T-lymphocytes with 0 and 2 chromosomes in associations, some of them being activated with mumps virus antigens. The correlation between AIAC and the lymphocyte blast-transformation reaction to phytohemagglutinins was variable in different groups of children and absent between AIAC and the amount of serum immunologlobulins. In combination with other immunological methods AIAC in T-lymphocytes of the blood may be used for characterization of the immune response.

[Evacuation function of a musculovenous "pump" of the leg in varicose veins of the lower extremities]. / Evakuatornaia funktsiia myshechno-venoznoi "pompy" goleni u bol'nykh varikoznoi bolezn'iu nizhnikh konechnostei.

The investigation of average time of transport of radionuclide along the venous system of lower extremities was used by the authors to assess the evacuation function of the musculo-venous "pump" of the leg in 10 healthy people and 50 patients with varicose disease of lower extremities. The direct relation between the degree of incompetence of the musculo-venous "pump" and the degree of the varicose disease speaks of its obvious pathogenetical role in the development of venous pathology.

[Complex radionuclide evaluation of the hemodynamic state in varicose veins of the lower extremities]. / Kompleksnaia radionuklidnaia otsenka sostoianiia gemodinamiki u bol'nykh varikoznoi bolezn'iu nizhnikh konechnostei.

The main parameters of central hemodynamics and regional blood volumes were determined in 106 patients with lower limb varicosity by computer radiocardiography and radiometry of the lower limbs in horizontal and vertical positions of the body. It was found that the clinical stages of compensation and decompensation are paralleled by definite combinations of changes in the circulation volume, minute and stroke values of the cardiac output and regional blood volumes in the lower limbs. Comprehensive appraisal of circulation enabled the authors to distinguish a "transient" stage of the disease according to the character of changes in the main hemodynamic values. It is very difficult to determine this stage from the clinical signs. The study showed that the transition from the stage of compensation to that of decompensation in varicose disease is due to the time factor which is within the limits of up to ten years from the onset of the disease in most cases.

[Safety, antigenic activity, and epidemiologic effectiveness of live mumps vaccine from strain L-3. II. Antigenic activity and epidemiologic effectiveness]. / Bezvrednost', antigennaia aktivnost' i épidemiologicheskaia éffektivnost' zhivoi parotitnoi vaktsiny iz shtamma L-3. Soobshchenie II. Antigennaia aktivnost' i épidemiologicheskaia éffektivnost'.

The results obtained in the study of the antigenic activity and epidemiological effectiveness of live parotitis vaccine prepared from strain L-3 are presented. Children aged 3-7 years were shown to react to the injection of this preparation by the moderate production of virus-neutralizing antibodies (the percentage of persons with antibody titers of 1:8 and higher increased from 26.5 to 64.4). The most intensive antibody production was stimulated by the vaccines containing 40,000 and 20,000 viral particles in 1 vaccination dose. In seropositive children no significant shift in the antibody content was observed irrespective of the batch of the vaccine used. During 1 1/2 years of observation the morbidity rate of epidemic parotitis among children immunized with live parotitis vaccine was 6.9 times lower than among the unvaccinated children in the same groups and 8.8 times lower than among the children used as external control. The effectiveness rate of the vaccine was on the average 85.4% and 88.6%. The vaccines containing 40,000 and 20,000 HADU50 were found to have greater epidemiological effectiveness, while the epidemiological effectiveness of the vaccine containing 5,000 HADU50 was somewhat less. The effect of vaccination depended not only on the dose of the antigen and the initial state of the vaccines, but also on the extent of the coverage of children with vaccination in organized groups.

[Cytogenetic study of the effect of vaccinia virus on cells from embryo and adult mice]. / Tsitogeneticheskoe izuchenie vliianiia virusa ospovaktsiny na kletki vzroslykh myshei i émbrionov.

After immunization with vaccinia virus an increase in frequency of aneuploids and secondary chromosomal constrictions is observed in adult mice. Moreover, an increased frequency of chromosomal aberrations was demonstrated. The increase in the number of secondary chromosomal constrictions indicates an activation of nucleolar-organizing regions.