Comparison between the optical properties of aerosols in the fine and coarse fractions over Valladolid, Spain.

Continuous measurements of the optical properties of aerosol particles have been made at Valladolid, Spain, covering the period from June 2011 to July 2012. The measurements were made at two size cuts: sub-10 µm and sub-1 µm (PM10 and PM1). The data measured were the scattering and backscattering coefficients, σs and σbs, obtained from an integrating nephelometer, and the absorption coefficient, σa, obtained from a particle soot absorption photometer. Spectrally resolved data were obtained from both instruments at 3 wavelengths (blue/green/red) at low relative humidity (RH < 40%). The statistical data for the instruments were calculated based on the hourly averages. For the PM10 fraction, the hourly mean values of σs and σa at 550 nm were 33 Mm-1 (StD = 30 Mm-1) and 4 Mm-1 (StD = 3 Mm-1), respectively. For the PM1 fraction, σs and σa mean values were 16 Mm-1 (StD = 14 Mm-1) and 4 Mm-1 (StD = 3 Mm-1), also at 550 nm. The derived parameters analyzed were the single scattering albedo, ω0, the backscatter fraction, σbs/σs, and the Ångström exponents of scattering, absorption and single scattering albedo, αs, αa and αω0. The contribution of the PM10 and the PM1 fractions for all these parameters plays a central role throughout the paper, allowing an improved classification of aerosol types. Our data are dominated by elemental carbon (EC) and elemental carbon/organic carbon mixed (EC/OC). For the PM10 data, dust dominated aerosol is also observed. Although we found that fine particles contribute more than coarse particles for decreasing the ω0 values, results suggest that it is also necessary to quantify the effect of coarse particles. Fine particles were found to produce ω0 spectra that decrease with the wavelength, αω0 > 0, while PM10 fractions were found to produce spectra that can decrease or increase with the wavelength, 0 < αω0 < 0. Both daily cycle and monthly variations are analyzed and related to local features as well as the transport of particles from elsewhere. A diurnal pattern characteristic of urban areas is observed, but it is less evident on weekends. The main long range transport influences are Atlantic advection, anthropogenic events from Central Europe and dust events.

Systemic lupus erythematosus in Spanish males: a study of the Spanish Rheumatology Society Lupus Registry (RELESSER) cohort.

Objective The objective of this study was to describe the demographic, clinical, and immunological manifestations of systemic lupus erythematosus (SLE) in male patients. Methods A cross-sectional, multicenter study was carried out of 3651 patients (353 men, 9.7%, and 3298 women, 90.2%) diagnosed with SLE, included in the Spanish Rheumatology Society SLE Registry (RELESSER). Results Mean ages (18-92 years) of symptom onset were 37 (SD 17) years (men) and 32 (SD 14) years (women). Male/female ratio was 1/9. Age of onset of symptoms and age at diagnosis were higher in men than in women ( p < 0.001). Males were diagnosed earlier than females (p = 0.04) and had more cardiovascular comorbidities ( p < 0.001). Two hundred and thirty-six males (68%) with SLE required hospitalization in comparison with 1713 females (53%) ( p < 0.001). During follow-up, 208 patients died: 30 men (9.3%) and 178 women (5.9%) ( p = 0.02). As regards clinical manifestations, loss of weight ( p = 0.01), lymphadenopathies ( p = 0.02), and splenomegaly ( p = 0.02) were more common in male patients. Female patients were more likely to have inflammatory rash, alopecia, and arthritis ( p < 0.05). As for lung involvement, men with SLE had more pleural fibrosis ( p < 0.001) and pulmonary embolism ( p = 0.01). However, Raynaud's phenomenon was more common in women (35%) than in men (23.7%) ( p < 0.001); lupus nephritis was more common in men, being present in 155 (44.8%) of males versus 933 (29%) of females ( p < 0.001). Multivariate analysis showed that SLE patients with a high Charlson index (more than 3 points) and age > 50 years had a higher mortality (odds ratios 3.6 and 2.1, respectively). Furthermore, SLE patients who developed pulmonary hemorrhage, pulmonary hypertension, psychiatric involvement, complement deficiency, and hemophagocytic syndrome also had higher mortality, regardless of gender. Conclusion Patients with SLE over the age of 50 years have an increased risk of mortality. In Caucasians, age at diagnosis and symptom onset is higher in men than in women. The diagnostic delay is shorter in men. Male SLE patients present more cardiovascular comorbidities, and also more serositis, adenopathies, splenomegaly, renal involvement, convulsion, thrombosis, and lupus anticoagulant positivity than women.

Fístula vésico-lumbar por migración de la instrumentación posterior. Complicación a largo plazo en la escoliosis neuromuscular / Vesico-lumbar fistula due to migration of posterior instrumentation. Long-term complication of neuromuscular scoliosis

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Aerosol properties of mineral dust and its mixtures in a regional background of north-central Iberian Peninsula.

To broaden the knowledge about desert dust (DD) aerosols in western Mediterranean Basin, their fingerprints on optical and microphysical properties are analyzed during DD episodes in the north-central plateau of the Iberian Peninsula between 2003 and 2014. Aerosol columnar properties obtained from the AErosol RObotic NETwork (AERONET), such as aerosol optical depth (AOD), Ångström exponent (AE), volume particle size distribution, volume concentration (VC), sphericity, single scattering albedo, among others, are analyzed in order to provide a general characterization, being some of them compared to particle mass surface concentrations PM10, PM2.5, and their ratio, data obtained from EMEP network. The mean intensity of DD episodes exhibits: AOD440nm=0.27±0.12, PM10=24±18µg/m3, AE=0.94±0.40 and PM2.5/PM10=0.54±0.16. The AOD and PM10 annual cycles show maximum intensity in March and summer and minima in winter. A customized threshold of AE=1 distinguishes two types of dusty days, those with a prevailing desert character and those of mixed type, which is corroborated by sphericity values. Three well established intervals are obtained with the fine mode volume fraction (VCF/VCT). Coarse-mode-dominated cases (VCF/VCT≤0.2) present a mineral dust character: e.g., particle maximum concentration about 2µm, non-sphericity, stronger absorption power at shorter wavelengths, among others. The relevance of the fine mode is noticeable in mixtures with a predominance of particles about 0.2-0.3µm radii. Conditions characterized by 0.2

The use of the acute Pd/Pa drop after intracoronary nitroglycerin infusion to rule out significant FFR: CANICA (Can intracoronary nitroglycerin predict fractional flow reserve without adenosine?) multicenter study.

OBJECTIVE: Functional assessment of coronary artery stenosis is performed by measuring the fractional flow reserve (FFR) under hyperemic conditions (Adenosine). However, the use of adenosine portends limitations. OBJECTIVE: We sought to investigate the relationship and correlation between FFR and the Pd/Pa value obtained just after the intracoronary infusion (acute drop) of nitroglycerin (Pd/Pa-NTG) and if this parameter enhances diagnostic accuracy for FFR prediction compared to the resting baseline Pd/Pa. METHODS: We conducted a multicenter study including prospectively patients presenting intermediate coronary artery stenosis (30-70%) evaluated with pressure wire. Resting baseline Pd/Pa, Pd/Pa-NTG and FFR were measured. RESULTS: 283 patients (335 lesions) were included. Resting baseline Pd/Pa value was 0.72 to 1.0 (0.93 ± 0.04), Pd/Pa-NTG was 0.60 to 1.0 (0.87 ± 0.07) and FFR 0.55 to 1.0 (0.83 ± 0.08). The ROC curves for resting baseline Pd/Pa and for Pd/Pa-NTG, using a FFR ≤ 0.80 showed an AUC of 0.88 (95% CI: 0.84-0.92, P < 0.001) and 0.94 (95% CI: 0.92-0.96, P < 0.001) respectively. The optimal cutoff values of resting baseline Pd/Pa and Pd/Pa-NTG for an FFR > 0.80, were >0.96 and >0.88, respectively. These values were present in a 29.8% (n = 100) and a 47.1% (n = 158), of the total lesions. Scatter plots showed a better correlation and agreement points with Pd/Pa-NTG than resting baseline Pd/Pa. The cutoff value of Pd/Pa-NTG > 0.88 showed an excellent NPV (96.2% for FFR > 0.8 and 100% for FFR > 0.75) and sensitivity (95% for FFR > 0.8 and 100% for FFR > 0.75) which were consistently high across all the subgroups analysis. CONCLUSION: The cutoff value of acute Pd/Pa-NTG > 0.88 has a high NPV meaning adenosine-FFR can be avoided in almost half of lesions.

Thoracolumbar fractures without neurological impairment: A review of diagnosis and treatment.

An appropriate protocol and unified management of thoracolumbar fractures without neurological impairment has not been well defined.This review attempts to elucidate some controversies regarding diagnostic tools, the ability to define the most appropriate treatment of classification systems and the evidence for conservative and surgical methods based on the recent literature. Cite this article: Vilà-Canet G, García de Frutos A, Covaro A, Ubierna MT, Caceres E. Thoracolumbar fractures without neurological impairment: a review of diagnosis and treatment. EFORT Open Rev 2016;1:332-338. DOI: 10.1302/2058-5241.1.000029.

Do surgical expectations change depending on first time surgery or reoperation? A prospective cohort study in lumbar spine surgery.

PURPOSE: To assess whether patients undergoing lumbar spine surgery for the first time (Group 1) had different expectations from those undergoing lumbar spine surgery for a failed previous procedure (Group 2). METHODS: A prospective study that included 77 patients. A set of self-reported questionnaires was pre-operatively administered including VAS, Oswestry Disability Index (ODI), Zung Depression Scale and the NASS lumbar spine questionnaire (expectations scale). RESULTS: Fifty-six patients in Group 1 and 21 patients in Group 2. Both groups had high expectations with regard to the surgical procedure (n.s.). Depressed patients, despite being more disabled than non-depressed according to ODI (p 0.001), had similar expectations than non-depressed patients (n.s.). CONCLUSION: Patients' expectations remained very high despite having had a failed previous surgery for the same procedure.

Comparison of total water vapor column from GOME-2 on MetOp-A against ground-based GPS measurements at the Iberian Peninsula.

Water vapor column (WVC) obtained by GOME-2 instrument (GDP-4.6 version) onboard MetOp-A satellite platform is compared against reference WVC values derived from GPS (Global Positioning System) instruments from 2007 to 2012 at 21 places located at Iberian Peninsula. The accuracy and precision of GOME-2 to estimate the WVC is studied for different Iberian Peninsula zones using the mean (MBE) and the standard deviation (SD) of the GOME-2 and GPS differences. A direct comparison of all available data shows an overestimation of GOME-2 compared to GPS with a MBE of 0.7 mm (10%) and a precision quantified by a SD equals to 4.4mm (31%). South-Western zone presents the highest overestimation with a MBE of 1.9 mm (17%), while Continental zone shows the lowest SD absolute value (3.3mm) due mainly to the low WVC values reached at this zone. The influence of solar zenith angle (SZA), cloud fraction (CF), and the type of surface and its albedo on the differences between GOME-2 and GPS is analyzed in detail. MBE and SD increase when SZA increases, but MBE decreases (taking negative values) when CF increases and SD shows no significant dependence on CF. Under cloud-free conditions, the differences between WVC from GOME-2 and GPS are within the WVC error given by GOME-2. The changes of MBE and SD on Surface Albedo are not so evident, but MBE slightly decreases when the Surface Albedo increases. WVC from GOME-2 is, in general, more precise for land than for sea pixels.

Columnar and surface aerosol load over the Iberian Peninsula establishing annual cycles, trends, and relationships in five geographical sectors.

The study of atmospheric aerosol load over the Iberian Peninsula (IP) under a climatological perspective is accomplished by means of PM10 and AOD440 nm measurements from EMEP and AERONET networks, respectively, in the period 2000-2013. The PM10 annual cycles in five Iberian sectors show a main maximum in summer and a secondary maximum in spring, which is only observed in the southern area for the AOD climatology. The characteristics of PM10-AOD annual cycles of each geographical sector are explained by the different climatology of the air mass origins and their apportioning. The two magnitudes are correlated with a factor ranging between 20 and 90 depending on the sector. The temporal evolution of the aerosol load has shown a notable decrease in the IP since the 1980s. Statistically significant trends are obtained in the Northeastern sector with a reduction of 26% (period 1985-2000) for the total suspended particles, which continues for the PM10 data with a value of 35% per decade (2001-2013), and also in the whole column, 61% per decade in the AOD440 nm (2004-2013).

Cervical spine epithelioid hemangioendothelioma: case report.

UNLABELLED: Epithelioid Hemangioendothelioma (EHE) is a rare aggressive vascular tumor and can occur in almost all locations. Spine location is rare. There are just a few cases published in the literature and the longer series included only five cases. CASE REPORT: We report a case of a 58-year-old woman who presented with anemia and cervical pain without neurological deficit. Radiological diagnosis revealed a C2-C3 mass with vertebral artery involvement and liver metastases. Partial resection and arthrodesis followed by radiotherapy and chemotherapy were performed. Local control of the diseases was achieved but distance metastasis appears two years after surgery. CONCLUSIONS: EHE of the spine is extremely rare in clinic as a primary aggressive vascular tumor. Metastatic disease is the most important factor to predict prognosis. It is not clear in the literature which is the best surgical approach in this patients and it mainly depends of the location and systemic illness. En bloc resection or expanded resection supported with adjunct radiation therapy may present with acceptable results of local control of the tumor. Systemic disease control must be achieved with chemotherapy.

Absorption Ångström exponents of aerosols and light absorbing carbon (LAC) obtained from in situ data in Covilhã, central Portugal.

A field campaign was conducted from October 2009 to July 2010 at Covilhã, a small town located in the region of Beira Interior (Portugal) in the interior of the Iberian Peninsula. The ambient light-absorption coefficient, σ(a) (522 nm), obtained from a Particle Soot Absorption Photometer (PSAP), presented a daily mean value of 12.1 Mm⁻¹ (StD = 7.3 Mm⁻¹). The wavelength dependence of aerosol light absorption is investigated through the Ångström parameter, α(a). The α(a) values for the pair of wavelengths 470-660 nm ranged from 0.86 to 1.47 during the period of measurements. The PSAP data were used to infer the mass of light absorbing carbon (LAC) and the daily mean varied from 0.1 to 6.8 µg m⁻³. A detailed study of special events with different aerosol characteristics is carried out and, to support data interpretation, air masses trajectory analysis is performed.

In situ UV-VIS-NIR absorbing properties of atmospheric aerosol particles: estimates of the imaginary refractive index and comparison with columnar values.

In this work, a novel technique is used to estimate the aerosol complex index of refraction of in situ collected samples. Samples of atmospheric particulate matter were collected in El Arenosillo, southern Spain, on polycarbonate filters during summer 2004 as part of an aerosol characterization campaign. These samples were analyzed for the volumetric absorption coefficient in the 320-800 nm spectral region and an estimation of the effective imaginary refractive index was made. The values of the imaginary part of the complex refractive index ranged between 0.0009-0.0215 at 800 nm and 0.0015-0.0114 at 320 nm. Little dependence on the wavelength was observed. Several intense and long lasting desert outbreaks were registered during the campaign and the complex refractive index almost doubles its value during these dust events. Finally, we present a comparison of data obtained in situ with columnar data obtained from the AERONET network. A correlation factor of 0.64 was obtained between both data, which gives an idea of how accurately the in situ ground data represent the total column.

Síndrome meníngeo y síndrome de cola de caballo tras cirugía de hernia discal lumbar L5-S1: evolución a los dos años / No disponible

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[Bilateral idiopathic carpal tunnel syndrome in a child under 10 years of age]. / Síndrome del túnel carpiano idiopático bilateral en un niño menor de 10 años.

INTRODUCTION: The carpal tunnel syndrome is the most frequent compression neuropathy in the adult population, being very uncommon in children, particularly under the age of 10 years. The most frequent etiology is the lisosomal storage diseases, followed by anatomical disorders, trauma, intensive sports practice and some idiopathic cases among others. In this paper we are presenting a case of an idiopathic and bilateral carpal tunnel syndrome in a 9 years old boy. CASE REPORT: A 9 year-old patient suffering daily paresthaesias in both hands for a year, producing limitations in hand mobility which disappear after physical movement of the hands. He played basketball at school, he was right handed and had no history of systemic family illnesses. After the exploration, he scored 4/5 in left thumb abductor strength and no thenar muscle hypotrophy. He achieved the criteria of attention deficit and hyperactivity disorder. Electroneurography tests confirmed the diagnosis. The etiology study was normal after completed. After bilateral surgery, the patient achieved a complete recovery. CONCLUSIONS: The importance of this clinical case lies in its rare manifestation in children under the age of 10, being bilateral and not being included in the most frequent etiology group. It has a late diagnosis because it has an etiology and clinical manifestation different from adults. The diagnosis is being done through electroneurography. Open surgical release is almost ever the treatment.

Síndrome del túnel carpiano idiopático bilateral en un niño menor de 10 años / Bilateral idiopathic carpal tunnel syndrome in a child under 10 years of age

Introducción. El síndrome del túnel carpiano es la neuropatía por compresión más frecuente en el adulto. Sin embargo, es un cuadro raro en la edad pediátrica, sobre todo por debajo de los 10 años de edad. La etiología más frecuente son las enfermedades de depósito lisosomal, seguidas por las anomalías anatómicas, casos familiares, traumatismos, práctica intensiva de ciertos deportes y casos idiopáticos. Presentamos un caso de síndrome del túnel carpiano, bilateral e idiopático enun niño de 9 años. Caso clínico. Niño de 9 años que presentaba desde hacía un año parestesias diurnas en ambas manos, con dificultad en la manipulación y que desaparecían tras movilizarlas. Era un jugador de baloncesto escolar, diestro y sin enfermedadessistémicas familiares. Cumplía los criterios de trastorno por déficit de atención/hiperactividad. La exploración mostró una fuerza de 4/5 en el músculo abductor del pulgar izquierdo. No había hipotrofia de la musculatura tenar. La electroneurografíaconfirmó el diagnóstico de síndrome del túnel carpiano. Se completó el estudio etiológico, que resultó normal. Tras realizar la cirugía bilateral, el paciente presentó una mejoría sintomática completa. Conclusiones. La importancia de este caso clínico es la rareza de su presentación en niños menores de 10 años, sobre todo con afectación bilateral y sin pertenecer al grupo etiológico más frecuente. La etiología y la sintomatología clínica distintas a las del adulto condicionan que el diagnóstico sea tardío. El diagnóstico de confirmación se realiza por electroneurografía y el tratamiento es casi siempre quirúrgico

Introduction. The carpal tunnel syndrome is the most frequent compression neuropathy in the adult population,being very uncommon in children, particularly under the age of 10 years. The most frequent etiology is the lisosomal storage diseases, followed by anatomical disorders, trauma, intensive sports practice and some idiopathic cases among others. In this paper we are presenting a case of an idiopathic and bilateral carpal tunnel syndrome in a 9 years old boy. Case report. A 9 year-old patient suffering daily paresthaesias in both hands for a year, producing limitations in hand mobility which disappearafter physical movement of the hands. He played basketball at school, he was right handed and had no history of systemic family illnesses. After the exploration, he scored 4/5 in left thumb abductor strength and no thenar muscle hypotrophy. Heachieved the criteria of attention deficit and hyperactivity disorder. Electroneurography tests confirmed the diagnosis. The etiology study was normal after completed. After bilateral surgery, the patient achieved a complete recovery. Conclusions. The importance of this clinical case lies in its rare manifestation in children under the age of 10, being bilateral and not being included in the most frequent etiology group. It has a late diagnosis because it has an etiology and clinical manifestationdifferent from adults. The diagnosis is being done through electroneurography. Open surgical release is almost ever the treatment

Posible validez de medicamentos termolábiles fuera de las condiciones de conservación recomendadas por el fabricante / No disponible

El farmacéutico de hospital, según Ley 25/1990, de 20 de diciembre del Medicamento, debe garantizar la correcta conservación de los medicamentos tanto en el servicio de farmacia comoen los stocks del hospital. El almacenado y conservación de los medicamentos termolábiles en las condiciones establecidas por el fabricante, garantiza la estabilidad y condiciones óptimas de utilización hasta la fecha de caducidad. La rotura de la cadena de frío puede condicionar significativamente la actividad y toxicidad de estos medicamentos. El farmacéutico debe tomar decisiones rápidas en situaciones donde se haya producido alguna eventualidad en la cadena del frío, de ahí la importancia de disponer de datos actualizados de su estabilidad a temperaturas distintas a las recomendadas. Se ha realizado una revisión de la información disponible sobre estabilidad de los medicamentos que requieren conservación en frigorífico de uso más frecuente en el medio hospitalario (AU)

Hospital pharmacists, according to the Ley del Medicamento25/1990 of 20th December, should ensure appropriate drug preservation within the Pharmacy Department and in hospital stocks.The storage and preservation of thermolabile drugs according to manufacturer recommendations guarantees stability and optimaluse conditions until the expiry date. Cold chain disruption may significantly affect the activity and toxicity of these drugs. Pharmacists should make quick decisions in case of cold chain-relatedevents, hence the relevance of up-to-date information on stability under temperatures differing from those recommended. A review of the information available on the stability of drugs commonly used in the hospital setting that require a fridge for storage has been carried out (AU)

[A case of Carney syndrome]. / Un caso de síndrome de Carney.

The Carney complex is an autosomal dominant syndrome characterised by multiple neoplasies, including myxomas at various sites (cardiac, cutaneous, mammary), spotty pigmentation, endocrine overactivity (Cushing's syndrome, acromegalia), testicular tumours and schwannomas. This report describes the case of a 43-year-old woman with an acute inferior myocardial infarction, probably due to coronary embolization from a large left atrial myxoma and who presented this association. A brief review of the Carney complex is provided after discussion of this rare case that required an screening of family members.

DNA computing on surfaces.

DNA computing was proposed as a means of solving a class of intractable computational problems in which the computing time can grow exponentially with problem size (the 'NP-complete' or non-deterministic polynomial time complete problems). The principle of the technique has been demonstrated experimentally for a simple example of the hamiltonian path problem (in this case, finding an airline flight path between several cities, such that each city is visited only once). DNA computational approaches to the solution of other problems have also been investigated. One technique involves the immobilization and manipulation of combinatorial mixtures of DNA on a support. A set of DNA molecules encoding all candidate solutions to the computational problem of interest is synthesized and attached to the surface. Successive cycles of hybridization operations and exonuclease digestion are used to identify and eliminate those members of the set that are not solutions. Upon completion of all the multistep cycles, the solution to the computational problem is identified using a polymerase chain reaction to amplify the remaining molecules, which are then hybridized to an addressed array. The advantages of this approach are its scalability and potential to be automated (the use of solid-phase formats simplifies the complex repetitive chemical processes, as has been demonstrated in DNA and protein synthesis). Here we report the use of this method to solve a NP-complete problem. We consider a small example of the satisfiability problem (SAT), in which the values of a set of boolean variables satisfying certain logical constraints are determined.