1.
Org Biomol Chem
; 18(26): 4936-4940, 2020 07 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32583841
RESUMO
A convenient and efficient palladium-catalyzed approach has been developed for the synthesis of 5-amino-1,2,4-oxadiazoles from amidoximes and isocyanides. Various 5-amino-1,2,4-oxadiazoles were obtained in moderate to high yields under mild conditions. The key to the success of this strategy involves new C-N bond and C-O bond formation via palladium-catalyzed isocyanide insertion.