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In order to alleviate the rapid capacity decay caused by the instability of the crystal structure and electrode/electrolyte interface, a series of Li2SiO3-coated LiNi0.5Mn1.5O4 materials have been prepared via the lithium acetate-assisted sol-gel method followed by a short-term calcination process. During the sol-gel process, TEOS is hydrolyzed, condensed, and polymerized with the assistance of lithium acetate to form a Li+-embedded [Si-O-Si]n network structure to ensure the uniformity of the coating. By changing the amount of TEOS and lithium acetate, the coating thickness can be precisely controlled, whose effects on the structural and electrochemical properties of LiNi0.5Mn1.5O4 materials are intensively investigated. The results show that the material with an appropriate thickness of Li2SiO3 coating exhibits a larger primary particle size and reduced secondary particle agglomeration. The uniform Li2SiO3 coating with appropriate thickness can not only improve Li+ ion diffusion kinetics but also suppress side reactions and CEI growth at the electrode/electrolyte interface. Besides, the interaction of Li2SiO3 with HF can alleviate electrode corrosion and the dissolution of transition metal ions. All the abovementioned factors together promote the significant improvement of the electrochemical performance of Li2SiO3-coated LiNi0.5Mn1.5O4 materials.
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Nowadays, it is a common practice for healthcare professionals to spread medical knowledge by posting health articles on social media. However, promoting users' intention to share such articles is challenging because the extent of sharing intention varies in their eHealth literacy (high or low) and the content valence of the article that they are exposed to (positive or negative). This study investigates boundary conditions under which eHealth literacy and content valence help to increase users' intention to share by introducing a moderating role of confirmation bias-a tendency to prefer information that conforms to their initial beliefs. A 2 (eHealth literacy: high vs. low) × 2 (content valence: positive vs. negative) between-subjects experiment was conducted in a sample of 80 participants. Levels of confirmation bias ranging from extreme negative bias to extreme positive bias among the participants were assessed during the experiment. Results suggested that: (1) users with a high level of eHealth literacy were more likely to share positive health articles when they had extreme confirmation bias; (2) users with a high level of eHealth literacy were more likely to share negative health articles when they had moderate confirmation bias or no confirmation bias; (3) users with a low level of eHealth literacy were more likely to share health articles regardless of positive or negative content valence when they had moderate positive confirmation bias. This study sheds new light on the role of confirmation bias in users' health information sharing. Also, it offers implications for health information providers who want to increase the visibility of their online health articles: they need to consider readers' eHealth literacy and confirmation bias when deciding the content valence of the articles.
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Background: Pulsed radiofrequency (PRF) on the dorsal root ganglion (DRG) has been applied to alleviate neuropathic pain effectively, yet the mechanisms underlying pain reduction owing to this treatment are not clarified completely. The activated microglia, brain-derived neurotrophic factor (BDNF), phosphatidylinositol 3-kinase (PI3K), and phosphorylated extracellular signal-regulated kinase (p-ERK) in the spinal cord were demonstrated to be involved in developing neuropathic pain. Also, it has been just known that PRF on DRG inhibits the microglial activation in nerve injury rats. Here, we aim to investigate whether PRF treatment could regulate the levels of BDNF, PI3K, and p-ERK in the spinal cord of rats with spared nerve injury (SNI) via suppressing the spinal microglia activation to ease neuropathic pain. Methods: The rats with SNI were intrathecally treated with minocycline (specific microglia inhibitor) or same volume of dimethyl sulfoxide once daily, beginning from 1 h before nerve transection to 7 days. PRF was applied adjacent to the L4-L5 DRG of rats with SNI at 45 V for 6 min on the seventh postoperative day, whereas the free-PRF rats were treated without PRF. The withdrawal thresholds were studied, and the spinal levels of ionized calcium-binding adapter molecule 1 (Iba1), BDNF, PI3K, and p-ERK were calculated by western blot analysis, reverse transcription-polymerase chain reaction, and immunofluorescence. Results: The paw withdrawal mechanical threshold and paw withdrawal thermal latency decreased in the ipsilateral hind paws after SNI, and the spinal levels of Iba1, BDNF, PI3K, and p-ERK increased on day 21 after SNI compared with baseline (P < 0.01). An intrathecal injection of minocycline led to the reversal of SNI-induced allodynia and increase in levels of Iba1, BDNF, PI3K, and p-ERK. Withdrawal thresholds recovered partially after a single PRF treatment for 14 days, and SNI-induced microglia hyperactivity, BDNF upregulation, and PI3K and ERK phosphorylation in the spinal cord reduced on D14 due to the PRF procedure. Conclusion: Microglial BDNF, PI3K, and p-ERK in the spinal cord are suppressed by the therapy of PRF on DRG to ease SNI-induced neuropathic pain in rats.
