Comparative analysis of domestic and foreign coal mine safety supervision modes based on knowledge map.

In order to grasp the research status and hot frontier of coal mine safety supervision mode in the world in the past 40 years, this paper takes the relevant literature in the field of "coal mine safety" and "supervision" included in the core collection of Web of Science (WOS) and the core journals of CNKI as the data source; based on the methods of statistical analysis and bibliometrics, the visualization analysis software CiteSpace is used to draw the map of scientific knowledge. Through the visualization analysis of the main research institutions, countries, and authors in this field, the main research forces and the distribution of researchers in this field are described. Through the visualization analysis of key words and research clustering, the research hotspots and future development trends in this field are described. The results show that the research hotspots of coal mine safety supervision mode at home and abroad are roughly the same, and the researchers and institutions in this field still need to further carry out cross regional and cross departmental wide area cooperation.

Phosphatidylcholine Ameliorates LPS-Induced Systemic Inflammation and Cognitive Impairments via Mediating the Gut-Brain Axis Balance.

Systemic inflammation will cause an imbalance in the steady state of the gut-brain axis. Phosphatidylcholine (PC) is a phospholipid found in egg yolk that has anti-inflammatory and antioxidant properties. The present research proved that PC supplementation (60 mg/kg body weight) for 35 days prevented inflammatory responses and behavioral disturbances in lipopolysaccharide (LPS)-induced mice. PC could regulate the expression of neurotrophic factors and synaptic proteins, which effectively alleviated the nerve damage and synaptic dysfunction caused by LPS. In addition, PC supplementation ameliorated gut barrier damage, altered gut genes, and improved gut health by modulating the cell adhesion molecule (CAM) pathway. Furthermore, PC remodeled the gut microbiome structure in the mice of the LPS group by increasing the relative abundance of Rikenellaceae and Lachnospiraceae. PC also increased short-chain fatty acid (SCFA) production in LPS-induced mice, which in turn ameliorated brain inflammatory responses. In conclusion, PC supplementation may be a nutritional strategy for the prevention of systemic inflammation via the gut-brain axis.