RESUMO
We examined the role of CCRL2 in ischemic brain injury using both in vitro and in vivo mouse stroke models. The expression of CCRL2 was enhanced at both the RNA and protein levels in cultured brain slices under ischemic conditions. Ischemia-induced cell death was reduced in brain slices derived from CCRL2 knockout (KO) mice in comparison with those from wild type (WT) mice. The infarct volume was smaller and neurological deficits were attenuated in CCRL2 KO mice when compared to WT mice subjected to a transient middle cerebral artery occlusion. Our data suggest that CCRL2 is involved in ischemia-induced brain injury in mice.
RESUMO
Europium doped lanthanide fluoride (LaF3) nanoparticles were prepared through a hydrothermal method with different PH values of precursor complex solution. The influence of PH value on the luminescence properties is investigated. It was found that the local symmetry of doped ions reduced with the increase of PH value, leading to the increase of the inversion symmetry ratio. The fluorescence quenching was observed for small nanoparticles, which was attributed to the large amount of OH groups absorbed to the surface of the nanoparticles.
