Occupational exposure to polybrominated diphenyl ethers or decabromodiphenyl ethane during chemical manufacturing: Occurrence and health risk assessment.

Field investigations were conducted on a decabrominated diphenyl ether (BDE-209) manufacturing plant and a decabromodiphenyl ethane (DBDPE) manufacturing plant, and worker exposure to polybrominated diphenyl ethers (PBDEs) or DBDPE was assessed. Workshop air was collected and tested to measure levels of external exposure to corresponding chemicals via air inhalation. Paired human serum and urine samples taken from 202 workers were tested to assess levels of internal BFR exposure. Levels of BDE-209 in air for the BDE-209 plant ranged from 10.6 to 295 µg m-3, accounting for at least 99% of the total PBDEs in the workshop air, and those of DBDPE in air samples from the DBDPE plant ranged from 12.7 to 435 µg m-3. Maximum estimated daily intakes (EDIs) of BDE-209 and DBDPE accumulated via air inhalation exceeded the corresponding RfD level recommended by the U.S. Environmental Protection Agency, indicating that for some workers, occupational exposure is likely to create significant health problems. The levels of BDE-209 measured in serum taken from BDE-209 workers ranged from 0.202 to 57.1 µg g-1 lw, and those of DBDPE in serum taken from DBDPE workers ranged from 0.087 to 54.4 µg g-1 lw. These values are several orders of magnitude higher than those detected in general areas and e-waste recycling sites. BDE-209 and DBDPE were detected in all of the urine samples with median levels of 1.12 and 8.6 ng mL-1, respectively, and levels of BDE-209 and DBDPE in the urine were significantly and positively correlated with those observed in the serum.

Disruption of thyroid hormone levels by decabrominated diphenyl ethers (BDE-209) in occupational workers from a deca-BDE manufacturing plant.

While there is some evidence that exposure to decabrominated diphenyl ethers (BDE-209) affects thyroid function, the results obtained to date have been inconsistent. No studies have been performed on workers in deca-BDE manufacturing who had a high level of exposure to BDE-209 and relatively little exposure to other contaminants. In the present study, the relationship between BDE-209 exposure and thyroid hormone in occupational workers from a deca-BDE manufacturing plant was investigated. The serum and urine levels of polybrominated diphenyl ethers (PBDEs) and serum thyroid hormones were measured in 72 workers recruited from the deca-BDE manufacturing plant. The associations between their thyroid hormone levels and their exposure to BDE-209 were examined using multiple linear regression models. Serum concentrations of BDE-209 ranged from 67.4 to 109,000 ng/g lipid weight (lw), with a median of 3420 ng/g lw, contributing to 93.1% of the total PBDEs. The concentration of BDE-209 in urine was highly correlated with that in the serum (r2 = 0.440, p < 0.001), indicating that urine may be a good non-invasive biomonitoring medium of BDE-209 body burden in occupational workers. BDE-209 in the serum was significantly and positively correlated with total thyroxine (tT4, r = 0.270, p = 0.029) and marginally and positively correlated with total triiodothyronine (tT3, r = 0.232, p = 0.061) in all occupational workers after adjusting for gender, age, BMI, and occupational exposure duration. A 10-fold increase in the serum BDE-209 concentration was associated with an increase in tT4 (8.63 nmol/L) [95% confidence interval (CI): 0.930-16.3] and tT3 (0.106 nmol/L) [95% confidence interval (CI): -0.005-0.219], corresponding to the increase of 7.8% in tT4 level and 5.4% in tT3 level. Associations between urine BDE-209 levels and thyroid hormones were similar to the results for the serum levels. These findings offer new evidence for proving the thyroid disrupting effects of BDE-209, impacting the direction of hyperthyroidism.