RESUMO
To investigate the changes of insulin resistance and soluble intercellular adhesion molecule-1 (sICAM-1) in normotensive adolescents with a family history of hypertension (FH) and to analyse the related factors. The study included 142 normotensive adolescents aged 13-15 years. On the basis of an FH, the samples were divided into positive FH (FH(+) group) and negative FH groups (FH(-) group). Anthropometric measurements included height, weight, waist circumference (WC) and blood pressure (BP). Blood samples were collected and fasting plasma glucose (FPG), serum lipids, true insulin (TI) and sICAM-1 were assayed. The FH(+) group had significantly higher levels of FPG, TI, homeostasis model assessment of insulin resistance (HOMA-IR) and sICAM-1 than the FH(-) group (P<0.01). HOMA-IR showed positive correlation with body mass index (BMI; r=0.405), WC (r=0.416), systolic BP (SBP; r=0.165), FPG (r=0.427), triglyceride (r=0.195), TI (r=0.993) and negative correlation with high density lipoprotein cholesterol (r=-0.196) (P<0.05). sICAM-1 showed a positive correlation with triglyceride (r=0.239, P<0.01). In multiple linear regression analysis, WC (beta=0.024, P=0.000) and FH (beta=0.467, P=0.000) were significant independent predictors for HOMA-IR, and triglyceride (beta=0.328, P=0.007) and FH (beta=0.395, P=0.016) were significant independent predictors for sICAM-1. These results indicate that insulin resistance and endothelial activation were found in normotensive adolescents with an FH. We should make great efforts to alleviate the insulin resistance and endothelial activation by diet and exercise, and it would reduce the incidence of hypertension in adolescents with an FH.
Assuntos
Endotélio Vascular/metabolismo , Hipertensão/genética , Resistência à Insulina/genética , Molécula 1 de Adesão Intercelular/sangue , Adolescente , Biomarcadores/sangue , Glicemia/análise , Pressão Sanguínea/genética , Estatura/genética , Peso Corporal/genética , Endotélio Vascular/fisiopatologia , Feminino , Predisposição Genética para Doença , Humanos , Hipertensão/fisiopatologia , Insulina/sangue , Modelos Lineares , Lipídeos/sangue , Masculino , Linhagem , Fenótipo , Medição de Risco , Circunferência da Cintura/genéticaRESUMO
Objective To explore the risk factors of cardiovascular disease in adolescents with a family history of hypertension.Methods A cross-sectional study was conducted in 3874 adolescents ages 13-18 years,with normal BP in 3724 people.Based on family history of hypertension (FH),the cohort of adolescents were dichoto- mized as postive family history (FH~+,n=1145) and negative (FH~-,n=2579).Height,weight,waist circum- ference,hip circumference,blood pressure and fasting plasma glucose(FPG),total cholesterol(TC),triglyceride (TG) and high-density lipoprotein cholesterol(HDL-C) were determined.Results FH~+ adolescents had signifi- cantly higher levels of body mass index(BMI),waist circumference,WHR,FPG,TC and LDL-C(P
RESUMO
Objective To delineate the relationship between body mass index(BMI),waist-to-height ratio (WHtR)and hypertension in adolescents.Methods A cross-sectional study was conducted in 3874 adolescents ages 13-18 years.They were classified into four groups according to BMI and WHtR,group A:normal BMI and WHtR
