Surveillance and research on acute meningitis, encephalitis syndrome in Guangxi, China / 中华预防医学杂志

<p><b>OBJECTIVE</b>To estimate disease burden and epidemiological characteristics of acute meningitis/encephalitis, and provide the basis for the disease control strategy development.</p><p><b>METHODS</b>A syndrome surveillance system was established in Guigang city with a population of 5 020 000. For the suspected cases, serum and CSF were collected, and bacterial culture, latex agglutination test, real-time PCR and ELISA tests were carried out. All involved cases were identified to 6 categories according to WHO case definition.</p><p><b>RESULTS</b>1424 suspected cases were evaluated in a surveillance of 30 months, yielding the incidence, mortality and mortality of 11.35/100 000 (1424/12 546 500 person years), 0.43/100 000 (54/12 546 500 person years), 3.79% (54/1424) respectively. A total of 103 and 51 cases were confirmed for JE, bacterial meningitis, with a incidence of 0.82/100 000 (103/12 546 500 person years), 0.41/100 000 (51/12 546 500 person years). 96.10% (99/103) of JE cases and 37.30% (19/51) bacterial meningitis cases occurred in < 10 years old children and < 5 years old children. A clinical misdiagnosis rate of 19.42% (20/103) and 15.69% (8/51) were observed for JE and bacterial meningitis.</p><p><b>CONCLUSION</b>Acute encephalitis, meningitis syndrome can cause a higher burden of disease, of which the main components of viral encephalitis. Most of syndrome is occurred in summer and autumn, mainly reported in children of younger than 10 years old. A quite misdiagnosis would be made among meningitis and encephalitis syndrome cases.</p>

Identification and analysis of an SEO strain of hemorrhagic fever with renal syndrome hantavirus from Guangxi / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>To identify hantavirus from lung specimens of rats captured in Guangxi.</p><p><b>METHODS</b>Rats were collected from various areas in Guangxi in combination with plague surveillance and rat lung specimens were examined by ELISA for hantavirus antigen, and M segment of positive specimen was partially amplified with RT-PCR and sequenced. Phylogenetic analysis was conducted for genotyping.</p><p><b>RESULTS</b>From a total of 306 rat lung specimens, a strain of SEO hantavirus was detected from lung specimen of a Norvegicus that was from coastal area of Guangxi Qinzhou city.</p><p><b>CONCLUSIONS</b>For the first time SEO hantanvirus was detected in the coastal area of Guangxi Qinzhou city, its epidemiological significance needs further study.</p>