PARAMETERS OF CENTRAL AND INTRACARDIAC HAEMODYNAMICS IN WOMEN WITH THYROID HYPERPLASIA AND ACALCULOUS CHOLECYSTITIS.

OBJECTIVE: Aim: The study aimed to investigate some parameters of functional status of central and intracardiac haemodynamics in women with thyroid hyperplasia and acalculous cholecystitis. PATIENTS AND METHODS: Materials and Methods: Functional changes of haemodynamic status in women with thyroid hyperplasia and acalculous cholecystitis were investigated. All data are obtained through general and special clinical methods, standard and special laboratory methods of examination, physiological, biochemical and statistical methods. Parameters of central and intracardiac haemodynamics have been recorded by the method of two-dimensional M-mode echocardiography in the echo chamber "Toshiba-140" (Japan) at the resting state. RESULTS: Results: An increase in heart rate (by 45.6%) was observed in patients, which led to decreased duration of cardiac cycle and ejection time. Statistically significant (p<0.05, 11.7% on average) increase in total peripheral vascular resistance was indicated. Dynamics of changes of parameters of central and intracardiac haemodynamics indicates different parallel existing pathways of secondary disturbances in the part of cardiovascular system. A significant increase in peripheral vascular resistance associated with decreased elasticity (increased vascular rigidity) of the arteries is the element of concentric type of left ventricular hypertrophy. The increase in volume in the absence of vasospastic reactions and increasing venous tone is an element of eccentric hypertrophy. CONCLUSION: Conclusions: It is possible to talk about the presence of systolic dysfunction in patients, which, however, is predominantly of functional character. The revealed specific changes in homeostatic haemodynamic characteristics in the women's body with thyroid hyperplasia and acalculous cholecystitis require the development of new, more effective and preferably drug-free (due to liver pathology and detoxification dysfunction) approaches to medical treatment of such patients.

[Immunotropic reaction onto balneotherapy by mineral water «naftusia¼ of women with hyperplasia of the thyroid gland and non-calcular cholecystitis].

OBJECTIVE: Introduction: Hyperplasia of the thyroid gland is recetly widespread, especially among women, with pathology. At structural changes of a gland there are various types of violations of the hormonal status of the organism - from hyperthyroidism through euthyroidism to hypothermia. The aim: The article aims at investigation of the peculiarities of the influence of mineral water "Naftusia" on the immunological status of women with non-calcular cholecystitis and hyperplasia of the thyroid gland, as well as the substantiation of the possibilities of using balneotherapy in the treatment of this pathology on the basis of the obtained data. PATIENTS AND METHODS: Materials and methods: Object of investigation- hyperplasia of the thyroid gland in the presence of women's non calcular cholecystitis. Subject of research -hormonal and immune status and their changes under the influence of mineral water "Naftusia". Methods of investigation: general clinical, standard laboratory methods of examination, special clinical and laboratory methods: physiological, biochemical, statistical. The evaluation of the immune system was carried out by determining the serum total blood levels of total immunoglobulins G, M, A. The level of immunoglobulins in the blood serum was determined by radial immune diffusion according to Mancini. RESULTS: Results and conclusions: The analysis of obtained results, makes it possible to characterize fully the positive influence of such a non-medicamentous item, as the use of mineral water "Naftusia" for the treatment of noncalcular cholecystitis. Under the influence of water "Naftusia", in one way or another, the cellular and phagocytic links of immunity are normalized. It can be assumed that a positive effect on the immune system is realized through the normalization of the processes of division and differentiation of cells of the immune system, in particular on the membrane level.