RESUMO
Insulin resistance and endothelial dysfunction are major cardiovascular risk factors. The purpose of this study was to determine whether only patients with insulin resistance also have an alteration of endothelial function assessed by ultrasound flow-mediated (FMD). In a population of 165 patients, 30 subjects had only a family history of diabetes and/or sporadic findings of hypoglycemia, and they were assessed for FMD, the glucose and insulin curve. Of these 30 subjects, 20 patients had an alteration of the parameters measured and were related with 20 healthy patients. The study group and the control group showed a markedly significant statistical difference in the performance of the curve insulin, in the calculation of FMD and HOMA. FMD allows to study populations with no apparent cardiovascular risk and to monitor the effectiveness of possible endothelial protective therapy.
Assuntos
Endotélio Vascular/diagnóstico por imagem , Endotélio Vascular/fisiopatologia , Resistência à Insulina , Vasodilatação , Adulto , Algoritmos , Biomarcadores/sangue , Velocidade do Fluxo Sanguíneo , Glicemia/metabolismo , Índice de Massa Corporal , Estudos de Casos e Controles , Gráficos por Computador , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/epidemiologia , Feminino , Humanos , Insulina/sangue , Itália/epidemiologia , Masculino , Síndrome Metabólica/complicações , Síndrome Metabólica/epidemiologia , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Fatores de Risco , Ultrassonografia Doppler/métodosRESUMO
Ion channels are essential to a wide range of physiological functions including neuronal signaling, muscle contraction, cardiac pacemaking, hormone secretion and cell proliferation. Linking ion-channel gene mutations to inherited disorders has been described. Ankyrins are intracellular proteins required for the biogenesis and maintenance of membrane domains in both excitable and non-excitable cells. Dysfunction in ankyrin-based pathways seems to link abnormalities in vertebrate physiology including ataxia, axonal degeneration and arrhythmias. Analyzing the evolution of the autonomic disturbances in the demyelinating syndromes, the early onset of arrhythmias has been described. We present a case of supraventricular tachycardia in a 45-year-old Italian woman with a clinically isolated demyelinating syndrome. Also this case focuses attention on the presence of arrhythmias in the demyelinating syndromes.
