RESUMO
Two new antifungal antibiotics, F2928-1 (1) and -2 (2), were isolated from the culture broth of Cladobotryum sp. These compounds were purified by solvent extraction, silica gel column chromatography and preparative HPLC, consecutively. The structures of these compounds were assigned as a decalin compound on the basis of various spectral analyses. These compounds showed antimicrobial activity against fungi including clinically important fungus, Aspergillus fumigatus.
Assuntos
Antifúngicos , Aspergillus fumigatus/efeitos dos fármacos , Compostos de Epóxi/farmacologia , Hypocreales/química , Naftalenos/farmacologia , Antifúngicos/química , Antifúngicos/isolamento & purificação , Antifúngicos/farmacologia , Fenômenos Químicos , Química , Cromatografia Líquida de Alta Pressão , Compostos de Epóxi/isolamento & purificação , Fermentação , Hypocreales/metabolismo , Naftalenos/isolamento & purificaçãoRESUMO
A novel nematicidal antibiotic, paeciloxazine has been isolated from the culture broth of a fungus Paecilomyces BAUA3058 strain. This compound, whose structure was determined by spectroscopic methods, has a pyrrolobenzoxazine skeleton. Paeciloxazine has moderate cidal activity against Rhabditis pseudoelongata and is weakly active against some insects.
