1.
Bioorg Med Chem Lett
; 17(13): 3736-40, 2007 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17467986
RESUMO
A series of isoxazole derivatives were synthesized and their antagonistic activities against LPA stimulation on both LPA(1)/CHO cells and rHSC cells were evaluated. Among them, 3-(4-[4-[1-(2-chloro-cyclopent-1-enyl)-ethoxycarbonylamino]-isoxazol-3- y]]-benzylsulfanyl)-propionic acid (34) showed the most potent activities.
Assuntos
Química Farmacêutica/métodos , Isoxazóis/síntese química , Lisofosfolipídeos/antagonistas & inibidores , Animais , Células CHO , Proliferação de Células , Cricetinae , Cricetulus , Desenho de Fármacos , Fibrose/patologia , Humanos , Concentração Inibidora 50 , Isoxazóis/química , Fígado/citologia , Lisofosfolipídeos/química , Propionatos/química , Ratos
2.
J Antibiot (Tokyo)
; 59(4): 251-3, 2006 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16830894
RESUMO
A new nucleoside derivative, AJP117510 (1) was isolated from unidentified fungus AJ117510. The structure of 1 was elucidated by spectroscopic analyses. Nucleoside 1 inhibited the binding of integrin alpha2beta1 to collagen in a dose dependent manner with an IC50 value of 5.9 microM.
