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Triflimide-Promoted Nucleophilic C-Arylation of Halopurines to Access N7-Substituted Purine Biaryls.
Chem Pharm Bull (Tokyo)
; 69(9): 886-891, 2021 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34148910
RESUMO
Functionalized nucleobases are utilized in a wide range of fields; therefore, the development of new synthesis methods is essential for their continued application. With respect to the C6-arylation of halopurines, which possess a substituent at the N7-position, only a small number of successful cases have been reported, which is predominately a result of large steric hinderance effects. Herein, we report efficient and metal-free C6-arylations and SNAr reactions of N7-substituted chloropurines in aromatic and heteroatom nucleophiles promoted by triflimide (Tf2NH) in fluoroalcohol.
Assuntos
Cicloexanonas/química , Purinas/química , Antivirais/síntese química , Antivirais/química , Purinas/síntese química , Estereoisomerismo
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