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1.
Biol Trace Elem Res ; 105(1-3): 229-48, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16034167

RESUMO

To study the preventive effect of supplemented chromium picolinate (CrPic) on the development of diabetic nephropathy in mice, we analyzed the effects of CrPic supplementation on renal function and concentrations of serum glucose and tissue chromium (Cr). In experiment 1, male KK-Ay obese diabetic mice were fed either a control diet (control) or a diet supplemented with 2 mg/kg diet (Cr2) or 10 mg/kg diet (Cr10) of Cr for 12 wk. Cr10 significantly ameliorated hyperglycemia after a glucose load, creatinine clearance rates, and urinary microalbumin levels (p<0.05). In experiment 2, the Cr10 diet was fed to male KK-Ay obese diabetic mice and C57BL nondiabetic mice for 4 wk. The CrPic diet reduced urinary albumin excretion in the diabetic mice (p<0.05). Inductively coupled plasma-mass spectrometry analysis revealed that the renal Cr content and the recovery of renal Cr concentration after Cr supplementation were significantly lower in the diabetic mice than in the nondiabetic mice (p<0.01). These observations suggest that Cr supplementation of type 2 diabetic mice reduces the symptoms of hyperglycemia and improves the renal function by recovering renal Cr concentration.


Assuntos
Metabolismo dos Carboidratos , Cromo/metabolismo , Diabetes Mellitus Tipo 2/tratamento farmacológico , Diabetes Mellitus Tipo 2/metabolismo , Suplementos Nutricionais , Quelantes de Ferro/farmacologia , Rim/metabolismo , Ácidos Picolínicos/farmacologia , Animais , Glicemia/metabolismo , Peso Corporal , Creatinina/metabolismo , Diabetes Mellitus Experimental/metabolismo , Neuropatias Diabéticas/prevenção & controle , Glucose/metabolismo , Teste de Tolerância a Glucose , Insulina/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Fatores de Tempo
2.
J Nutr ; 133(3): 752-7, 2003 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-12612148

RESUMO

The aim of the present study was to determine the effects of dietary proteins on the oxidation of dietary carbohydrate and lipids in type II diabetic mice. KK-A(y) strain mice were provided free access to a high fat diet (30% of energy as fat) for an initial 4-wk period to induce diabetes. To reduce body weight gain, the mice were subsequently fed restrictive isoenergetic and isonitrogenous diets (35% of energy as protein and 5% as fat) based on either casein or soy protein isolate hydrolysate (SPI-H) for 4 wk. To measure exogenous carbohydrate and lipid oxidation, the mice were fed a diet containing (13)C-glucose or (13)C-triolein while they were in a respiratory chamber for 72 h. Postprandial energy expenditure was higher in the SPI-H than in the casein group; this difference was due to an increase in postprandial exogenous and endogenous carbohydrate oxidation. There were no differences in 24-h energy expenditure between dietary groups. Oxidation of exogenous carbohydrate tended to be higher (P = 0.054) in the SPI-H group during the 24 h of measurement. Fecal excretion of (13)C-glucose was lower but the excretion of lipid was higher in mice fed the SPI-H diet than in casein-fed mice. These results indicate that in type II diabetic mice, dietary SPI-H not only inhibits the absorption of dietary lipids and increases the absorption of dietary carbohydrates but also augments postprandial energy expenditure, which is accompanied by a postprandial increase in oxidation of dietary carbohydrates.


Assuntos
Diabetes Mellitus Tipo 2/metabolismo , Carboidratos da Dieta/metabolismo , Proteínas Alimentares/administração & dosagem , Metabolismo Energético , Proteínas de Soja/administração & dosagem , Animais , Peso Corporal , Isótopos de Carbono/metabolismo , Caseínas/administração & dosagem , Carboidratos da Dieta/farmacocinética , Gorduras na Dieta/metabolismo , Gorduras na Dieta/farmacocinética , Ingestão de Energia , Fezes/química , Absorção Intestinal , Masculino , Camundongos , Oxirredução , Trioleína/administração & dosagem , Trioleína/metabolismo , Trioleína/farmacocinética
3.
Biosci Biotechnol Biochem ; 67(12): 2505-11, 2003 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-14730126

RESUMO

The effects of an amino acid mixture simulating dietary soybean protein on the postprandial energy metabolism was investigated using type II diabetic mice. KK-A(y) strain mice were fed restrictive isoenergetic and isonitrogenous diets (35% of energy as protein and 5% as fat) based on either casein, soybean protein isolate hydrolysate (SPI-H), SPI-HET (ethanol unsoluble fraction of SPI-H), SPI-AA and casein-AA (amino acid mixtures simulating SPI-H and casein). To measure dietary carbohydrate oxidation, the animals were fed a diet containing (13)C-glucose. Postprandial respiratory quotient and expired (13)CO(2) were higher in the SPI-AA than in the casein-AA group, as the differences were similarly observed in mice fed SPI-H and casein diet. No significant differences were observed in the postprandial respiratory quotient and expired (13)CO(2) between the SPI-H and SPI-HET group. In conclusion, this study on food-restricted mice indicates that the amino acid mixtures simulating SPI-H or casein could affect postprandial energy metabolism in diabetic mice, as observed in those fed SPI-H or casein in the form of peptide or protein.


Assuntos
Aminoácidos/farmacocinética , Diabetes Mellitus Tipo 2/metabolismo , Carboidratos da Dieta/farmacocinética , Metabolismo Energético/fisiologia , Proteínas de Soja/farmacocinética , Animais , Peso Corporal/fisiologia , Caseínas/farmacocinética , Glucose/farmacocinética , Lipídeos/farmacocinética , Masculino , Camundongos , Oxirredução , Período Pós-Prandial/fisiologia , Hidrolisados de Proteína/farmacocinética
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