RESUMO
We experienced 2 cases of Stage â £ colorectal cancer obtained long-term survival by chemotherapy with only capecitabine. Case 1: Seventy-one-years-old male was performed open sigmoid colectomy, D2 dissection for sigmoid colon cancer. Pathological diagnosis was pT4aN2aM0, pStage â ¢c. Capecitabine plus oxaliplatin(CAPOX)was performed as adjuvant chemotherapy for 6 months consequently. Two-years after operation, peritoneal dissemination was found, and CAPOX plus bevacizumab(BEV)was started. Due to appearance of renal disfunction and proteinuria, only capecitabine was continued. Since then, 60 months have been passed without disease progression. Case 2: Seventy-six-years-old female was diagnosed as ascending colon cancer with multiple lung metastases. She had initially given systematic chemotherapy with CAPOX plus BEV. Grade 2 adverse effect(numbness and diarrhea)appeared, then the chemotherapy was discontinued. Seven months later, bowel obstruction due to tumor growth was appeared, and open right-hemi colectomy, with D3 dissection was performed for relief of symptoms. Pathological diagnosis was pT3N1bM1a, pStage â £a. With her request, chemotherapy was performed with only capecitabine. Although lung metastasis was slowly progressed, for 72 months she has maintained good general condition since the chemotherapy with only capecitabine was started.