RESUMO
The authors conducted an investigation in order to ascertain whether or not L-carnitine, by promoting the utilization of FFA for energy and neutralizing FFA toxicity occurring after ischaemia, could prevent or confine adriamycin-induced cardiotoxicity in rabbits. The results show that L-carnitine determines a higher survival rate and reduced onset of cardiomyopathy. Histopathological examination of myocardial tissue under light and electron microscopy revealed a marked decrease in mitochondrial lesions.
Assuntos
Cardiomiopatias/prevenção & controle , Carnitina/farmacologia , Carnitina/uso terapêutico , Doxorrubicina/toxicidade , Animais , Cardiomiopatias/induzido quimicamente , Cardiomiopatias/patologia , Masculino , Mitocôndrias Cardíacas/efeitos dos fármacos , Mitocôndrias Cardíacas/ultraestrutura , Miocárdio/ultraestrutura , CoelhosRESUMO
20 (12 men and 8 women) acute myocardial infarction (AMI) patients and 17 (14 men and 3 women) patients with arterial hypertension (II degrees stage according to OMS) in comparison to controls age and sex matched, were studied, serum IgA, IgG, IgM were evaluated with radial immunodiffusion and serum IgE with RIA. Ho significant changes ef immunoglobulins were observed between hypertensive patients and controls; whereas a significant increase of IgM, IgG and IgE, with out changes of IgA, were shown in AMI patients. Serum Ig and IgM were significantly augmented in AMI patients in comparison to hypertensive patients.
Assuntos
Hipertensão/imunologia , Imunoglobulinas/análise , Infarto do Miocárdio/imunologia , Idoso , Feminino , Humanos , Imunodifusão , Imunoglobulina A/análise , Imunoglobulina E/análise , Imunoglobulina G/análise , Imunoglobulina M/análise , Masculino , Pessoa de Meia-IdadeRESUMO
After a review of the literature on heart damage in rickettsiosis, the data from a clinical and ecgraphic investigation of 17 patients suffering from boutonneuse fever are reported. There was little cardiovascular involvement and inconstant hypotension but two heart complications are described, one myocardial ischaemia which cleared up a few days after the end of the diseases, and an atrial fibrillation that lasted two days. Stress is laid on the need for constant ecgraphic monitoring, even in this minor rickettsiosis.
Assuntos
Febre Botonosa/complicações , Doenças Cardiovasculares/etiologia , Infecções por Rickettsiaceae/complicações , Adulto , Arteriopatias Oclusivas/etiologia , Arteriopatias Oclusivas/patologia , Artérias/patologia , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/etiologia , Febre Botonosa/patologia , Capilares/patologia , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/patologia , Doença das Coronárias/diagnóstico , Doença das Coronárias/etiologia , Doença das Coronárias/patologia , Ecocardiografia , Feminino , Humanos , Hipotensão/diagnóstico , Hipotensão/etiologia , Perna (Membro)/irrigação sanguínea , Masculino , Pessoa de Meia-Idade , Miocárdio/patologia , Febre Maculosa das Montanhas Rochosas/patologia , Tifo Endêmico Transmitido por Pulgas/patologiaRESUMO
Complications are rare in boutonneuse fever. This is clear from the brief review offered of the relevant literature. Reference is made to the clinical records of a personal series collected in Sicily during the current endemo-epidemic expansion of the disease through some regions of Italy. Primary complications appear in the form of cutaneous vesicles, a pyramidally located psychosensorial syndrome, transient atrial fibrillation and myocardial ischaemia, anuria with hyperazotaemia and another severe renal impairment. Careful clinical investigation of cases with unusual symptoms is recommended, coupled with systematic pathogenetic examination along modern lines.
Assuntos
Febre Botonosa/complicações , Surtos de Doenças , Infecções por Rickettsiaceae/complicações , Febre Botonosa/epidemiologia , Doença das Coronárias/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Doenças do Sistema Nervoso/etiologia , Tratos Piramidais/fisiopatologia , Sicília , Dermatopatias Vesiculobolhosas/etiologia , Uremia/etiologiaAssuntos
Diabetes Mellitus/fisiopatologia , Estado Pré-Diabético/fisiopatologia , Fluxo Sanguíneo Regional , Adolescente , Adulto , Vasos Sanguíneos/fisiologia , Criança , Feminino , Humanos , Perna (Membro)/irrigação sanguínea , Masculino , Pletismografia de Impedância , Pressorreceptores/fisiologiaAssuntos
Carbamatos/farmacologia , Carbamatos/uso terapêutico , Estado Pré-Diabético/tratamento farmacológico , Piridinolcarbamato/farmacologia , Piridinolcarbamato/uso terapêutico , Fluxo Sanguíneo Regional/efeitos dos fármacos , Adulto , Vasos Sanguíneos/efeitos dos fármacos , Vasos Sanguíneos/metabolismo , Feminino , Pé/irrigação sanguínea , Humanos , Masculino , Pletismografia de Impedância , Estado Pré-Diabético/fisiopatologiaAssuntos
Carbamatos/farmacologia , Angiopatias Diabéticas/tratamento farmacológico , Piridinolcarbamato/farmacologia , Animais , Artérias/efeitos dos fármacos , Artérias/metabolismo , Coagulação Sanguínea/efeitos dos fármacos , Bradicinina/antagonistas & inibidores , Vasos Coronários/efeitos dos fármacos , Angiopatias Diabéticas/metabolismo , Angiopatias Diabéticas/fisiopatologia , Glicoproteínas/metabolismo , Masculino , Microcirculação/efeitos dos fármacos , Pletismografia de Impedância , Ratos , Fluxo Sanguíneo Regional/efeitos dos fármacosRESUMO
The epidemiological, clinical and instrumental features of cerebral circulatory insufficiency are examined in an assessment of the criteria required for correct diagnosis. The need to refer to both direct and indirect criteria is illustrated in the light of a series of cases. From the 4th decade of life onwards, males are more prone to cerebral arteriosclerosis. Hypertension, diabetes and obesity are significant risk factors. The findings obtained by various methods of examination are critically discussed. Their correct interpretation naturally demands correlation with the clinical data.
Assuntos
Arteriosclerose Intracraniana/diagnóstico , Adulto , Fatores Etários , Idoso , Colesterol/sangue , Complicações do Diabetes , Feminino , Humanos , Hiperlipidemias/complicações , Hipertensão/complicações , Arteriosclerose Intracraniana/etiologia , Arteriosclerose Intracraniana/metabolismo , Metabolismo dos Lipídeos , Lipoproteínas/sangue , Masculino , Pessoa de Meia-Idade , Obesidade/complicações , Fatores Sexuais , Triglicerídeos/sangueRESUMO
A group of atherosclerotic patients, some of whom were diabetics with clinical and instrumental signs of angiopathy, was treated with pyridinolcarbamate which was found to be elective for diabetic angiopathy. This was seen in the improvement in haemocoagulative alterations (platelet adhesiveness and clumping), that in certain lipidico-plasmatic alterations (normalization or reduction of glycoproteins) and in anatomofunctional modifications at wall level (rheographic modifications and changes in the diffusion curves with Alb labelled with I 131). These improvements were not observed in atherosclerotic subjects.