1.
Farmakol Toksikol
; 50(6): 33-7, 1987.
Artigo
em Russo
| MEDLINE
| ID: mdl-2893744
RESUMO
The native sum of valepotriates isolated from Val. alliariifolia Adams which was named valiracyl is an agent of low toxicity and exerts a pronounced neurotropic effect. Valiracyl suppresses the orientation reflex of animals in an "open field", decreases a spontaneous and caffeine-stimulated motor activity, potentiates and prolongs the action of barbiturates, significantly reduces aggressiveness of animals, decreases sensitivity to the convulsant effects of corasol and thiosemicarbazide, produces the antihypoxic and mild myorelaxant actions. The neurotropic effects of valiracyl are related to increased level of the GABA inhibition mediator and decreased intensity of bioenergetic processes in the brain.
Assuntos
Iridoides , Plantas Medicinais , Piranos/farmacologia , Valeriana , Agressão/efeitos dos fármacos , Animais , Ansiolíticos , Anticonvulsivantes , Encéfalo/metabolismo , Relação Dose-Resposta a Droga , Masculino , Camundongos , Atividade Motora/efeitos dos fármacos , Relaxamento Muscular/efeitos dos fármacos , Ratos , Ácido gama-Aminobutírico/metabolismo
2.
Farm Zh
; (2): 67-71, 1978.
Artigo
em Ucraniano
| MEDLINE
| ID: mdl-658346
3.
Farm Zh
; 32(1): 73-6, 1977.
Artigo
em Ucraniano
| MEDLINE
| ID: mdl-862861
4.
Farm Zh
; 29(2): 67-70, 1974.
Artigo
em Ucraniano
| MEDLINE
| ID: mdl-4463060