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Behav Brain Res ; 359: 446-456, 2019 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-30447239

RESUMO

Lethal yellow (AY) mutation causes obesity and type-2 diabetes in mice. Here we studied the effect of the AY mutation on the brain and behavior. The experiments were carried out on adult (11-12 weeks old) males of AY/a mice and their wild-type littermates (a/a). Mice of AY/a and a/a genotypes did not differ in their home cage activity, sleep, food and water consumption, learning ability in the Morris water maze, anxiety in the open field and elevated plus-maze, as well as in the level of monoamines, metabolites and some genes expression in the brain. At the same time, the fat mass, depressive-like immobility in the forced swim and tail suspension tests were significantly increased in AY/a mice compared with a/a ones. Magnetic resonance imaging revealed a significant reduction of cortex volume in AY/a mice. The level of mRNA of Ptpn5 gene encoding striatal enriched tyrosine phosphatase in the frontal cortex of AY/a mice was significantly elevated compared with their wild-type littermates. This is the first report on the alterations in the brain and behavior in the AY/a mouse line. It is tempting to speculate that this mouse line can serve as a new and useful preclinical model to study neurobehavioral complications associated with obesity and type-2 diabetes.


Assuntos
Proteína Agouti Sinalizadora/genética , Comportamento Animal/fisiologia , Encéfalo/metabolismo , Mutação , Proteína Agouti Sinalizadora/metabolismo , Animais , Composição Corporal/genética , Composição Corporal/fisiologia , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Estudos de Associação Genética , Masculino , Camundongos Endogâmicos C57BL , Atividade Motora/genética , Atividade Motora/fisiologia , Tamanho do Órgão , Proteínas Tirosina Fosfatases não Receptoras/metabolismo , RNA Mensageiro/metabolismo
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