1.
Bioorg Med Chem Lett
; 10(14): 1563-6, 2000 Jul 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10915051
RESUMO
A series of monocyclic and bicyclic amino acids have been synthesised and incorporated into thrombin inhibitors based on CGH728, an analogue of the Mitsubishi compound MD805. Benzthiazolylalanine (Bta) was found to be a good non-polar substitute for arginine at the P1 position, yielding compounds with low nanomolar potency and good selectivity for thrombin.