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Andrologia ; 48(5): 595-600, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26370185

RESUMO

The aim was to study the effect and time profile of a single dose of nandrolone decanoate (ND) on gonadotropins, blood lipids and HMG CoA reductase [3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR)] in healthy men. Eleven healthy male participants aged 29-46 years were given a single dose of 150 mg ND as an intramuscular dose of Deca Durabol®, Organon. Blood samples for sex hormones, lipids and HMGCR mRNA analysis were collected prior to ND administration day 0, 4 and 14. A significant suppression of luteinising hormone (LH) and follicle-stimulating hormone (FSH) was seen after 4 days. Total testosterone and bioavailable testosterone level decreased significantly throughout the observed study period. A small but significant decrease in sexual hormone-binding globulin (SHBG) was seen after 4 days but not after 14 days. Total serum (S)-cholesterol and plasma (P)-apolipoprotein B (ApoB) increased significantly after 14 days. In 80% of the individuals, the HMGCR mRNA level was increased 4 days after the ND administration. Our results show that a single dose of 150 mg ND increases (1) HMGCR mRNA expression, (2) total S-cholesterol and (3) P-ApoB level. The long-term consequences on cardiovascular risk that may appear in users remain to be elucidated.


Assuntos
Anabolizantes/administração & dosagem , Anabolizantes/efeitos adversos , Gonadotropinas/sangue , Hidroximetilglutaril-CoA Redutases/genética , Lipídeos/sangue , Nandrolona/análogos & derivados , Adulto , Apolipoproteínas B/sangue , Doenças Cardiovasculares/etiologia , Colesterol/sangue , Hormônio Foliculoestimulante/sangue , Humanos , Hormônio Luteinizante/sangue , Masculino , Pessoa de Meia-Idade , Nandrolona/administração & dosagem , Nandrolona/efeitos adversos , Decanoato de Nandrolona , RNA Mensageiro/sangue , RNA Mensageiro/genética , Fatores de Risco
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