RESUMO
Contact dermatitis to cutting fluids is a very frequent cause of occupational skin disease, with different mechanisms for those caused by irritation or allergies. The different allergens in question are many and complex. Different batteries of patch tests are available but the interpretation of the relevance of positive tests is not simple. The aim of this work is to make clearer the investigative methods and the interpretation of the relevance of the results of patch tests, for more effective prevention.
Assuntos
Doenças Profissionais/induzido quimicamente , Dermatopatias/induzido quimicamente , Temperatura Baixa , Dermatite de Contato/etiologia , Dermatite Ocupacional/diagnóstico , Humanos , Pneumopatias/etiologia , Doenças Profissionais/diagnóstico , Óleos , Testes do Emplastro , Dermatopatias/diagnósticoRESUMO
A new case of occupational asthma caused by Chrysonilia sitophila (asexual state of Neurospora sitophila) was diagnosed by molecular identification of the mold and confirmed by skin prick test, peak expiratory flow rate measurements, and experimental immunoglobulin E analysis.
Assuntos
Asma/diagnóstico , Neurospora/imunologia , Doenças Profissionais/diagnóstico , Adulto , Agricultura , Café , DNA Fúngico/química , DNA Fúngico/genética , Humanos , Masculino , Dados de Sequência Molecular , Ventilação Pulmonar , Análise de Sequência de DNA , Testes CutâneosRESUMO
Contact dermatitis to epoxydic and phenolic resins are the most frequent contact dermatoses due to plastics, in particular in the form of airborne dermatitis. The chemical formulas of the various components of these resins and their additives are complex and the patch tests available in the trade are insufficient and often arrive at a late stage in the progress of industry, in particular in advanced technologies like aeronautical engineering, shipbuilding or the new floor and wall coverings in buildings. This article is a review of the actions to be taken with these allergies, as well as with regards to their diagnosis, prevention and medico-legal compensation.
Assuntos
Poluentes Ocupacionais do Ar/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Dermatite Ocupacional/etiologia , Resinas Epóxi/efeitos adversos , Formaldeído/efeitos adversos , Fenóis/efeitos adversos , Polímeros/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/prevenção & controle , Dermatite Ocupacional/diagnóstico , Dermatite Ocupacional/prevenção & controle , França , Humanos , Testes do Emplastro/métodosRESUMO
BACKGROUND: Hepatic steatosis is a common feature in liver biopsies from patients with chronic hepatitis C and is associated with fibrosis progression. Patients with HIV infection and hepatitis C virus (HCV) coinfection have more rapid progression of liver fibrosis than patients with HCV infection alone. The prevalence and factors associated with hepatic steatosis are not well defined in HCV-HIV-coinfected patients. METHODS: Steatosis was assessed among 148 HCV-HIV-coinfected patients of the Aquitaine Cohort. Steatosis was graded as follows: none, mild (1%-10% of hepatocytes), moderate (11%-30%), severe (31%-60%), and massive (more than 60%). Epidemiologic, clinical, biologic, and therapeutic data were retrieved from the cohort database to investigate the risk factors. RESULTS: Steatosis was present in 67% of patients (95% confidence interval [CI]: 59% to 74%) and was at least moderate in 30% (95% CI: 23% to 38%). Steatosis was macrovesicular or mixed (macro- and microvesicular) in 40.5% and 52.8% of patients, respectively. Necroinflammatory activity was the only factor independent of steatosis (adjusted odds ratio = 5.3, 95% CI: 1.6 to 17.9). When necroinflammatory activity was removed from the model, HCV genotype 3 and body mass index (BMI) were significantly associated with steatosis. CONCLUSIONS: Liver inflammation, HCV genotype 3, and BMI are associated with steatosis, a common finding in HCV-HIV-coinfected patients.
