RESUMO
Splenosis is defined as the heterotopic autotransplantation of splenic tissue because of a ruptured spleen due to trauma or surgery. It is a benign and incidental finding, although imaging tests may sometimes orient toward malignancy simulating renal tumors, abdominal lymphomas, endometriosis, among other. We report the case of a 42-year old male in whom a MRI was performed after a study due to abdominal pain. Multiple enlarged lymph nodes were observed in the abdomen, suggestive of lymphoproliferative disease. As an important background, splenectomy was carried out due to abdominal trauma at age 9. After several studies, it was decided to perform a (99m)Tc-labeled heat-damaged red blood cell scintigraphy that showed multiple pathological deposits distributed throughout the abdomen, and even the pelvis, being consistent with splenosis.
Assuntos
Esplenose/diagnóstico por imagem , Traumatismos Abdominais/cirurgia , Dor Abdominal/etiologia , Adulto , Bromoexina , Colestase/diagnóstico , Diagnóstico Diferencial , Eritrócitos , Humanos , Achados Incidentais , Metástase Linfática , Transtornos Linfoproliferativos/diagnóstico , Imageamento por Ressonância Magnética , Masculino , Complicações Pós-Operatórias/diagnóstico por imagem , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/patologia , Radiografia , Cintilografia , Compostos Radiofarmacêuticos , Baço/lesões , Baço/cirurgia , Esplenectomia , Esplenose/epidemiologia , Esplenose/etiologia , Esplenose/patologia , Tecnécio , Fatores de TempoAssuntos
Adenocarcinoma/diagnóstico por imagem , Adenocarcinoma/secundário , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/secundário , Neoplasias Hepáticas/secundário , Tomografia por Emissão de Pósitrons , Neoplasias da Próstata/patologia , Compostos Radiofarmacêuticos , Medronato de Tecnécio Tc 99m , Idoso , Humanos , Neoplasias Hepáticas/diagnóstico por imagem , Masculino , Compostos Radiofarmacêuticos/farmacocinética , Medronato de Tecnécio Tc 99m/farmacocinética , Tomografia Computadorizada por Raios XRESUMO
The reversible acetylcholinesterase inhibitor, physostigmine, stimulated in a dose-dependent manner the accumulation of [3H]inositol monophosphate ([3H]IP1) in lithium-treated neostriatal slices. The muscarinic agonists, carbachol and oxotremorine, also stimulated [3H]IP1 accumulation. Atropine completely blocked the physostigmine-induced accumulation but had no effect on the basal accumulation. Tetrodotoxin partially inhibited the physostigmine-induced [3H]IP1 accumulation but had no effect on the carbachol-induced accumulation. 4-Aminopyridine stimulated the basal [3H]IP1 accumulation and potentiated the physostigmine-induced accumulation. This potentiation was blocked by tetrodotoxin. The physostigmine dose-response curve for the stimulation of [3H]IP1 accumulation was similar to its dose-response curve to inhibit acetylcholinesterase activity in the neostriatum. The results suggest that, under our experimental conditions, the acetylcholine released spontaneously from intrinsic cholinergic neurons does not activate the striatal muscarinic receptors coupled to phosphoinositide breakdown unless the intrinsic acetylcholinesterases are inhibited.
