[Selected parameters of the oxidative-antioxidative balance in children with chronic severe bronchial asthma]. / Ocena wybranych parametrów równowagi oksydacyjno-antyoksydacyjnej u dzieci chorych na przewlekla ciezka astme oskrzelowa.

The aim of this study was to evaluate the involvement of selected parameters of oxidative-antioxidative system in children with severe bronchial asthma. In our study the intensity of peroxide lipid oxidation was calculated by the contents of malonic dialdehyde in plasma. At the same time antioxidant activity was evaluated. The plasma contents of vitamin E and total antioxidant status were measured, as were activity of glutathione peroxidase and superoxide dismutase in blood. Our study was performed on 24 children treated for severe bronchial asthma. The control group consisted of 27 healthy children. The study has revealed that children suffering from bronchial asthma exhibit disturbances in the oxidative/antioxidative balance, manifested by increased oxidative activity and by changes in certain parameters of the antioxidative system. Our results support the theory of free radicals involvement in pathophysiology of severe bronchial asthma.

[Evaluation of respiratory tract functions in children with chronic renal failure treated with hemodialysis]. / Ocena czynnosci ukladu oddechowego u dzieci z przewlekla niewydolnoscia nerek leczonych hemodializami.

The respiratory tract functions were evaluated in 9 children with severe renal failure treated with hemodialysis. In the most of observed children the values of spirometric parameters were improved after hemodialysis.

[Mucociliary clearance in children with juvenile chronic arthritis evaluated with the saccharine test]. / Oczyszczanie sluzowo-rzeskowe u dzieci z mlodzienczym przewleklym zapaleniem stawów oceniane za pomoca testu sacharynowego.

The aim of this study was an evaluation of the mucociliary clearance of airways with saccharine test in children with juvenile chronic arthritis. In tested group the displacement time of saccharine was significantly longer than in healthy children. In control group the displacement time of saccharine was longer in children older 13 years, but in tested group the quality of mucociliary clearance was independent of age and of arthritis duration. The mucociliary clearance impairment wasn't dependent of increasing incidence of infections of respiratory system.

[Correlation between peak expiratory flow and selected indices of bronchial potency in children between 4 and 18 years of age]. / Korelacja miedzy szczytowym przeplywem wydechowym a wybranymi wskaznikami droznosci oskrzeli u dzieci w wieku od 4 do 18 roku zycia.

The study was conducted on 474 children diagnosed at the Lung Function Laboratory of the Children' Hospital in Lublin in the year 1992. 55% of the analyzed children were males. The children's initial diagnosis were: bronchial asthma, allergic rhinitis, chronic respiratory disorders, diabetes mellitus, abnormalities of the thorax. In 28 children no abnormalities were detected. PEF was measured with a Peak Flow Meter produced by Vitalograph. Children in the age group 4-6 years had PEF measured with a mini meter, reading values between 0 to 300 L/min. A standard meter was used for older children detecting values between 0 to 700 L/min. Spirometry, MEFV curves, resistance were analyzed with the abcPNEUMO 2000 spirometer (abcMED). Correlation was calculated between PEF and FEV1, MEF25, MEF50, MEF75, PEF, PIF, FEV1%FVC, Raw. Multiple regression analysis was performed to identify the best subpopulation of independent variants. In all children a correlation was found between PEF and the major parameters of airways potency. The weakest correlation was found in children younger than 6 years. PEF correlated best with FEV1 and MEF75.

[Use of ceftriaxone in urinary and respiratory tract infections]. / Zastosowanie ceftriaksonu w zakazeniach ukladu moczowego i oddechowego.

Efficiency of ceftriaxone (Rocephin Hoffman Laroche) was assessed in 16 children aged between 3 and 14 years and in 4 adults aged between 17 and 70 years with severe infections of the urinary and respiratory tracts caused by E. coli. S. pneumoniae, P. aeruginosa, P. mirabilis or enterococci. Pyelonephritis as a sole pathology was diagnosed in 10 patients whereas in further 8 patients it complicated other diseases (nephrotic syndrome, hepatitis, cholangitis, leukemia). Pneumonia complicated nephritis leukemia or lymphoma in 8 children. Peritonitis was diagnosed in 1 adult patient. Ceftriaxone was given in a single daily dose of 50 mg/kg to all children and 2.0 g to adult patients for 7-10 days. No adverse reactions were noted. Clinical improvement was achieved in all treated patients. Cultures became negative in 17 cases after the treatment. Significant bacteremia caused by P. aeruginosa persisted in 2 patients and by E. coli in 1 patient. No toxic effects on liver, renal, pancreatic and bone marrow functioning were seen. Ceftriaxone may be safely and efficiently used for the treatment of the urinary and respiratory infections.