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Eur J Paediatr Neurol ; 20(4): 611-5, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27061773

RESUMO

PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a progressive, lethal disease. Brain histopathology in certain SSPE patients shows, neurofibrillary tangles composed of abnormally phosphorylated, microtubule-associated protein tau (PHF-tau). Because the, phosphorylation of tau is inhibited by insulin and insulin-like growth factor-1 (IGF-1), we investigated cerebrospinal fluid (CSF) insulin and IGF-1 levels in SSPE patients. METHODS AND RESULTS: In this study CSF IGF-1 and insulin levels of 45 SSPE and 25 age-matched control patients were investigated. CSF IGF-1 levels were significantly higher in SSPE patients at stage 4, compared to other stages (p 0.05). CSF insulin and IGF-1 levels were both positively correlated with serum measles IgG. CONCLUSIONS: The correlation between CSF insulin and IGF-1 levels and serum measles virus IgG titer may be the result of, insulin activating IGF-1 receptors, and consequently, IGF-1 stimulating, plasma cells and enhancing IgG production. Increased IGF-1 may also, inhibit the phosphorylation of tau. Further studies examining the, correlation between IGF-1, insulin, tau, and PHF-tau levels in the same, patients may clarify any possible pathogenetic relation between these, pathways.


Assuntos
Fator de Crescimento Insulin-Like I/líquido cefalorraquidiano , Panencefalite Esclerosante Subaguda/líquido cefalorraquidiano , Encéfalo/metabolismo , Encéfalo/patologia , Estudos de Casos e Controles , Criança , Progressão da Doença , Feminino , Humanos , Imunoglobulina G/imunologia , Insulina/líquido cefalorraquidiano , Masculino , Sarampo/imunologia , Vírus do Sarampo/imunologia , Emaranhados Neurofibrilares/metabolismo , Emaranhados Neurofibrilares/patologia , Fosforilação , Índice de Gravidade de Doença , Panencefalite Esclerosante Subaguda/imunologia , Proteínas tau/metabolismo
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