RESUMO
The roots of Salvia blepharochlaena have yielded two new diterpenoids, blephaein (1) and O-methylpisiferic acid methyl ester (2), together with eight known diterpenoids. The structures of the new compounds were established by spectroscopic analysis and by some chemical reactions. Potent antibacterial activity was exhibited by the known compounds horminone (9) and 7-acetylhorminone (10) against Staphylococcus aureus ATCC 6538 P, Staphylococcus epidermidis ATCC 12226, and Bacillus subtilis ATCC 6633. Horminone was also found to be active against Enterococcus faecalis ATCC 29212.
Assuntos
Antibacterianos/isolamento & purificação , Diterpenos/isolamento & purificação , Lamiaceae/química , Antibacterianos/química , Antibacterianos/farmacologia , Bacillus subtilis/efeitos dos fármacos , Diterpenos/química , Diterpenos/farmacologia , Enterococcus faecalis/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Estrutura Molecular , Raízes de Plantas/química , Análise Espectral , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus epidermidis/efeitos dos fármacosRESUMO
The known ent-kaurene diterpenes 1-9 and a new ent-labdane, ent-6beta,8alpha-dihydroxylabda-13(16),14-diene (10), were isolated from the whole plant of Sideritis argyrea. Their structures were elucidated based on one- and two-dimensional NMR techniques and HRMS.
Assuntos
Diterpenos/química , Lamiaceae , Plantas Medicinais/química , Diterpenos/isolamento & purificação , Humanos , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Espectrofotometria InfravermelhoRESUMO
From the roots of Saliva caespitosa Montbret and Aucher ex. Bentham a new diterpene 6beta-hydroxyisopimaric acid (1) has been isolated together with four known diterpenes, one new triterpenoid, 3-acetylvergatic acid (2), as well as five known triterpenoids, two steroids and a flavone. The structures of the compounds were established by spectroscopic analyses. The isolated compounds were tested against standard bacterial strains. Only the new diterpene, 6beta-hydroxyisopimaric acid has strong activity (MIC 9 microg/ml) against S. aureus and (MIC 18 microg/ml) against S. epidermidis as well as against B. subtilis (MIC 9 microg/ml).
Assuntos
Antibacterianos/isolamento & purificação , Diterpenos/isolamento & purificação , Plantas Medicinais/química , Salvia/química , Esteroides , Antibacterianos/química , Antibacterianos/farmacologia , Bacillus subtilis/efeitos dos fármacos , Cromatografia em Camada Fina , Diterpenos/química , Diterpenos/farmacologia , Flavonoides/química , Flavonoides/isolamento & purificação , Flavonoides/farmacologia , Testes de Sensibilidade Microbiana , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Oxirredução , Raízes de Plantas/química , Espectrofotometria Infravermelho , Espectrofotometria Ultravioleta , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus epidermidis/efeitos dos fármacos , Esteroides/química , Esteroides/isolamento & purificação , Esteroides/farmacologia , Triterpenos/química , Triterpenos/isolamento & purificação , Triterpenos/farmacologia , TurquiaRESUMO
The roots of Lavandula stoechas ssp. stoechas afforded eleven known triterpenes, two steroids and two aromatics, in addition to two new triterpenes, 18-hydroxy-27-norolean-12,14-dien-30-al-28-oic acid and 3 beta-hydroxy-1-oxo-olean-12-ene-30-al-28-oic acid. Their structures were determined by spectroscopic analyses. The chloroform extract and some isolated compounds were evaluated for their growth inhibitory activity against several mammalian cell lines.
