RESUMO
Hemochromatosis is a multisystem disorder produced by the excessive accumulation of iron in visceral organs and the musculoskeletal system. Clinically the disease may be silent, but characteristic radiological features may point to the diagnosis. The increased iron stores in the organs involved, especially in the liver and pancreas, result in an increased attenuation at unenhanced CT and an decreased signal intensity at MR imaging. Hemochromatosis arthropathy includes degenerative osteoarthritis and chondrocalcinosis. The distribution of the arthropathy is distinctive, but not unique, frequently affecting the second and third metacarpophalangeal joints of the hand.
Assuntos
Hemocromatose/diagnóstico , Artropatias/diagnóstico , Hepatopatias/diagnóstico , Pancreatopatias/diagnóstico , Adulto , Condrocalcinose/diagnóstico , Condrocalcinose/etiologia , Feminino , Hemocromatose/complicações , Humanos , Artropatias/etiologia , Hepatopatias/etiologia , Imageamento por Ressonância Magnética , Masculino , Articulação Metacarpofalângica/diagnóstico por imagem , Pessoa de Meia-Idade , Osteoartrite/diagnóstico , Osteoartrite/etiologia , Pancreatopatias/etiologia , Tomografia Computadorizada por Raios XRESUMO
Crossing of the physis by primarily metaphyseal, localized bone tumors and osteomyelitis in childhood was rarely observed. Therefore, the physis in childhood is considered to be a barrier against the spread of tumors and infection. We report five children, in whom MR imaging demonstrated early crossing of the physis and spread of the disease from the metaphysis to the epiphysis. Follow-up in three children with osteomyelitis showed that antibiotic therapy resulted in almost complete resolution of the changes in the physis, epiphysis and metaphysis. These observations challenge the concept of the physis as a barrier against the spread of tumors and infection.
Assuntos
Neoplasias Ósseas/diagnóstico , Lâmina de Crescimento/patologia , Articulação do Joelho/patologia , Imageamento por Ressonância Magnética , Osteomielite/diagnóstico , Osteossarcoma/diagnóstico , Tíbia/patologia , Artrite Infecciosa/diagnóstico , Bacteriemia/diagnóstico , Criança , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Infecções por Salmonella/diagnóstico , Infecções Estafilocócicas/diagnósticoRESUMO
Inversion-Recovery RARE is a strongly T2-weighted fast sequence in which the CSF appears dark. This sequence was used in more than 100 patients. Retrospective analysis of 80 patients with cerebrovascular and inflammatory disease was carried out. The IR-RARE sequence proved to be particularly suitable for identifying small lesions in the neighbourhood of the subarachnoid space. We illustrate the typical contrast provided by this sequence, and describe its characteristics, exemplifying the advantages it offers for the diagnosis of multiple sclerosis, cerebral microangiopathy and brain infarction.
Assuntos
Encefalopatias/diagnóstico , Encéfalo/patologia , Transtornos Cerebrovasculares/diagnóstico , Imageamento por Ressonância Magnética/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Encefalopatias/líquido cefalorraquidiano , Encefalopatias/patologia , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/patologia , Infarto Cerebral/líquido cefalorraquidiano , Infarto Cerebral/diagnóstico , Infarto Cerebral/patologia , Transtornos Cerebrovasculares/líquido cefalorraquidiano , Transtornos Cerebrovasculares/patologia , Criança , Pré-Escolar , Diagnóstico Diferencial , Estudos de Avaliação como Assunto , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla/líquido cefalorraquidiano , Esclerose Múltipla/diagnóstico , Esclerose Múltipla/patologiaRESUMO
A 33-year-old man with dyskeratosis congenita received a marrow transplant to treat severe pancytopenia. The graft was successful-, but the patient developed severe acute graft-versus-host-disease grade IV and died 51 days postgrafting. - The outcome of transplantation in dyskeratosis congenita is compared to that in Fanconi's anaemia due to the resemblance of both diseases in some aspects.
